July 30, 2016 9:49 AM ET


Company Overview of Tokai Pharmaceuticals, Inc.

Company Overview

Tokai Pharmaceuticals, Inc., a biopharmaceutical company, focuses on developing and commercializing therapies for prostate cancer and other hormonally-driven diseases. Its lead drug candidate is galeterone, an oral small molecule that is in various clinical trials for the treatment of patients with metastatic castration-resistant prostate cancer. The company’s androgen receptor degradation (ARDA) drug discovery program is focused on identifying and developing compounds for ARDA activity. Tokai Pharmaceuticals, Inc. was founded in 2004 and is based in Boston, Massachusetts.

255 State Street

6th Floor

Boston, MA 02109

United States

Founded in 2004

24 Employees



Key Executives for Tokai Pharmaceuticals, Inc.

Chief Executive Officer, President and Director
Age: 41
Total Annual Compensation: $475.0K
Chief Financial Officer
Age: 35
Total Annual Compensation: $201.7K
Chief Medical Officer
Age: 58
Total Annual Compensation: $380.0K
General Counsel and Executive Vice President of Business Operations
Age: 48
Total Annual Compensation: $218.5K
Compensation as of Fiscal Year 2015.

Tokai Pharmaceuticals, Inc. Key Developments

Tokai Pharmaceuticals Announces Clinical Update

Tokai Pharmaceuticals Inc. announced that it plans to discontinue the ARMOR3-SV clinical trial, the company’s pivotal Phase 3 study comparing galeterone to enzalutamide in treatment-naïve metastatic castration-resistant prostate cancer (mCRPC) patients whose prostate tumors express AR-V7, following the recommendation made by the trial’s independent Data Monitoring Committee (DMC). Based on a review of all safety and efficacy data, the DMC determined that the ARMOR3-SV trial will likely not succeed in meeting its primary endpoint of demonstrating an improvement in radiographic progression-free survival (rPFS) for galeterone versus enzalutamide in AR-V7 positive mCRPC. In making its recommendation, the DMC did not cite any safety concerns with galeterone in the trial. ARMOR3-SV is the first pivotal clinical trial in mCRPC to prospectively select AR-V7 positive patients, a population with an unmet medical need and aggressive disease course. The company plans to present data from the trial in a scientific forum once fully available and analyzed. The company intends to evaluate its ongoing ARMOR2 expansion in mCRPC patients with acquired resistance to enzalutamide, and the planned study in patients who rapidly progress on either enzalutamide or abiraterone acetate. Tokai plans to allow all patients currently enrolled in the ARMOR2 and ARMOR3-SV trials to continue on therapy following consultation with their physicians and study investigators. The appropriate health authorities and clinical study investigators are being notified that ARMOR3-SV is being discontinued.

Tokai Pharmaceuticals, Inc. - Special Call

To provide clinical update to discontinue Phase 3 ARMOR3-SV Trial of Galeterone in AR-V7 Positive mCRPC

Tokai Pharmaceuticals, Inc. Presents at Jefferies 2016 Healthcare Conference, Jun-09-2016

Tokai Pharmaceuticals, Inc. Presents at Jefferies 2016 Healthcare Conference, Jun-09-2016 . Venue: The Grand Hyatt Hotel, New York, New York, United States.

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