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May 22, 2015 8:36 AM ET


Company Overview of Parion Sciences, Inc.

Company Overview

Parion Sciences, Inc., a pharmaceutical company, engages in the discovery and development of new treatments for serious diseases in multiple therapeutic areas. The company primarily focuses on developing therapeutic agents for pulmonary diseases, including cystic fibrosis, chronic obstructive pulmonary disorder, and bronchiectasis. It develops epithelial sodium channel blockers that are used for the treatment of diseases associated with lung, mouth, nose, and the gastrointestinal tract. The company also develops an oral rinse for the relief of chronic dry mouth; and compounds for patients suffering from dry eyes. It was formerly known as CYFI, Inc. and changed its name to Parion Sciences, In...

2800 Meridian Parkway

Suite 195

Durham, NC 27713

United States

Founded in 1999





Key Executives for Parion Sciences, Inc.

Co-Founder, Co-Chairman and Chief Executive Officer
Age: 69
Co-Founder and Co-Chairman
Chief Operating Officer
Age: 49
Senior Director of Clinical & Regulatory Operations
Compensation as of Fiscal Year 2014.

Parion Sciences, Inc. Key Developments

Parion Sciences Announces Initiation of Phase 2 Clinical Trial of P-1037 for the Treatment of Cystic Fibrosis

Parion Sciences announced that it has begun enrollment of a phase 2 clinical trial of P-1037 in patients with Cystic Fibrosis. The trial has been named the 'CLEAN-CF' trial which refers to 'Clearing Lungs with ENaC inhibition in Cystic Fibrosis'. The CLEAN-CF study will include CF patients regardless of an individual's genetic mutation. Inhibiting the epithelial sodium channels (ENaC) in the airways with P-1037, an 'ENaC blocker', is expected to re-hydrate the mucus layers, thus restoring airway clearance, improve lung function and, ultimately, reduce exacerbations. P-1037 has demonstrated to be long acting in preclinical models and to have a favorable safety and tolerability profile in the completed Phase 1 studies. Parion expects to enroll approximately 120 patients at 30 sites, most within CFFT's clinical trials national network.

Parion Sciences, Inc. Presents at SunTrust Robinson Humphrey Biotechnology and Pharmaceutical One-on-One Orphan Drug Day, Feb-23-2015

Parion Sciences, Inc. Presents at SunTrust Robinson Humphrey Biotechnology and Pharmaceutical One-on-One Orphan Drug Day, Feb-23-2015 . Venue: JW Marriott Essex House, 160 Central Park South, b/w 6th & 7th Avenue, New York, New York, United States.

Parion Sciences Announces Exclusive Option Agreement for the Development and Commercialization of P-321 in Ophthalmology in Certain Asian Territories

Parion Sciences, Inc. announced that Parion and Santen Pharmaceutical Co. Ltd. have entered into the "OPTION, LICENSE AND DEVELOPMENT AGREEMENT", an exclusive option agreement for the development and commercialization of P-321 for dry eye disease in certain Asian territories. On May 1, 2014 Parion announced FDA Acceptance of the Investigational New Drug Application for clinical testing of P-321 Ophthalmic Solution for the Treatment of Dry Eye Disease. Parion plans to initiate a Phase 1/2a clinical trial in patients suffering from dry eye disease in July, 2014 in the United States. Under the terms of agreement, Santen will make an undisclosed option payment to secure certain rights to P-321 and to support the upcoming Phase 1/2a clinical trial. Should Santen elect to exercise their option, Santen will have responsibility for all clinical, regulatory, and commercial activity for the ophthalmic use of P-321 in the agreed Asian territories. Parion retains all rights to develop and commercialize P-321 in the rest of the world, including North America and Europe.

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