Life Sciences Tools and Services
Company Overview of Seahorse Bioscience, Inc.
Seahorse Bioscience, Inc. engages in the design, development, manufacture, and supply of analytical instruments, biomanufacturing systems, and consumable labware products for biological research and drug discovery to the life sciences industry. It offers a line of extracellular flux (XF) instruments, including XFe96 and XFe24 analyzers that measure mitochondrial respiration and glycolysis in cells; XF24-3 analyzer that enables the measurement of the TCA cycle, as well as mitochondrial respiration and glycolysis; and XF prep station that removes growth medium replacing with run medium. The company’s consumable products include XF fluxpaks, cell culture and islet capture microplates, stress te...
16 Esquire Road
North Billerica, MA 01862
Founded in 2000
Key Executives for Seahorse Bioscience, Inc.
Founder, Chairman, Chief Executive Officer and President
Founder and Vice President of Seahorse Labware
Founder and Vice President of Administration & Finance
Founder and Chief Technology Officer
Founder and Vice President of Sales & Marketing
Compensation as of Fiscal Year 2015.
Seahorse Bioscience, Inc. Key Developments
Seahorse Bioscience Introduces XFp Cell Energy Phenotype Test Kit
Apr 20 15
Seahorse Bioscience introduced the XFp Cell Energy Phenotype Test Kit. The kit enables a unique real-time assay on live cells that determines their baseline metabolic phenotype and potential. This one-hour test measures both the mitochondrial and glycolytic activity of the cells, and compares their baseline values with metabolic activity under stressed conditions, induced by a single injection, to determine the metabolic potential – the cells' ability to respond to an energy demand. This kit has been designed specifically for use with the XFp Extracellular Flux Analyzer. Traditionally, mitochondrial respiration and glycolytic activity is obtained from a number of separate assays, with the comparison performed after the assay completion. The new XFp Cell Energy Phenotype Test is the only method available that can provide a metabolic phenotype with which scientists can make direct, functional comparisons of both metabolic pathways between groups of live cells. With this information cancer researchers can then quickly realize the functional consequences of somatic mutations in terms of metabolic adaptations and reprogramming events that drive tumor malignancies. By simultaneously measuring the relative utilization of the two major energy pathways under both basal and stressed conditions, researchers can now quickly realize the metabolic consequence of genetic changes. The XF Cell Energy Phenotype of tumors containing the Ras oncogenes shows a significant reliance on glycolysis for energy when stressed, revealing a metabolic vulnerability for survival in the hypoxic and acidic environment of a large tumor. The XFp Cell Energy Phenotype Test requires only a small amount of sample to measure the metabolic phenotype and metabolic potential of cells, and the XFp Cell Energy Phenotype Report Generator software automatically calculates the parameters of the test, simplifying data analysis and interpretation. The kit is used with the XFp Analyzer and is ideal for use in pair wise comparisons, as well as with patient-derived and other precious samples. With a better understanding of the connection of physiological traits of cells with genomic and proteomic data, scientists are generating new insights into metabolic function, leading to a greater understanding, and new treatments of disease.
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