February 26, 2017 3:11 AM ET

Life Sciences Tools and Services

Company Overview of Seahorse Bioscience, Inc.

Company Overview

Seahorse Bioscience, Inc. engages in the manufacture and distribution of metabolic analyzers and stress test kits for scientists to advance their research in understanding the role of cell metabolism in neurodegeneration, aging, cancer, cardiovascular, cell physiology, toxicology and hepatobiology, immunology, infectious diseases, mitochondrial diseases, model organisms, obesity, diabetes, metabolic disorders, screening, and translational medicine worldwide. It offers Seahorse XF instruments for analyzing mitochondrial respiration and glycolysis; Seahorse XFp Analyzer, which has built-in assay templates; Seahorse XFe96 Analyzer for large number of experimental groups per assay; Seahorse XFe2...

16 Esquire Road

North Billerica, MA 01862

United States

Founded in 2000

Phone:

978-671-1600

Fax:

978-671-1611

Key Executives for Seahorse Bioscience, Inc.

Founder, Chairman, Chief Executive Officer and President
Age: 59
Founder and Vice President of Seahorse Labware
Founder and Vice President of Administration & Finance
Founder and Chief Technology Officer
Founder and Vice President of Sales & Marketing
Compensation as of Fiscal Year 2016.

Seahorse Bioscience, Inc. Key Developments

Seahorse Bioscience Introduces XFp Cell Energy Phenotype Test Kit

Seahorse Bioscience introduced the XFp Cell Energy Phenotype Test Kit. The kit enables a unique real-time assay on live cells that determines their baseline metabolic phenotype and potential. This one-hour test measures both the mitochondrial and glycolytic activity of the cells, and compares their baseline values with metabolic activity under stressed conditions, induced by a single injection, to determine the metabolic potential – the cells' ability to respond to an energy demand. This kit has been designed specifically for use with the XFp Extracellular Flux Analyzer. Traditionally, mitochondrial respiration and glycolytic activity is obtained from a number of separate assays, with the comparison performed after the assay completion. The new XFp Cell Energy Phenotype Test is the only method available that can provide a metabolic phenotype with which scientists can make direct, functional comparisons of both metabolic pathways between groups of live cells. With this information cancer researchers can then quickly realize the functional consequences of somatic mutations in terms of metabolic adaptations and reprogramming events that drive tumor malignancies. By simultaneously measuring the relative utilization of the two major energy pathways under both basal and stressed conditions, researchers can now quickly realize the metabolic consequence of genetic changes. The XF Cell Energy Phenotype of tumors containing the Ras oncogenes shows a significant reliance on glycolysis for energy when stressed, revealing a metabolic vulnerability for survival in the hypoxic and acidic environment of a large tumor. The XFp Cell Energy Phenotype Test requires only a small amount of sample to measure the metabolic phenotype and metabolic potential of cells, and the XFp Cell Energy Phenotype Report Generator software automatically calculates the parameters of the test, simplifying data analysis and interpretation. The kit is used with the XFp Analyzer and is ideal for use in pair wise comparisons, as well as with patient-derived and other precious samples. With a better understanding of the connection of physiological traits of cells with genomic and proteomic data, scientists are generating new insights into metabolic function, leading to a greater understanding, and new treatments of disease.

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