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August 31, 2015 11:23 AM ET

Pharmaceuticals

Company Overview of Mersana Therapeutics, Inc.

Company Overview

Mersana Therapeutics, Inc. engineers antibody-drug conjugates that maximize the potential of new and established therapeutic classes. The company develops a portfolio of antibody-drug conjugates to improve patient outcomes in multiple oncology indications. Its clinical-stage product candidates include XMT-1001, a “tecan” conjugate for patients with lung cancers; and XMT-1107, an anti-angiogenic conjugate for patients with refractory, advanced solid tumors. The company’s conjugation system provides benefits for the development of drugs across therapeutic modalities, including antibody-drug conjugates, antibody fragments, small molecules, biologics, and synergistic drug combinations. Mersana T...

840 Memorial Drive

Cambridge, MA 02139

United States

Founded in 2001

Phone:

617-498-0020

Fax:

617-498-0109

Key Executives for Mersana Therapeutics, Inc.

Chief Executive Officer, President and Director
Age: 51
Executive Chairman
Age: 50
Co-Founder
Vice President of Finance
Head of Clinical Development & Regulatory Affairs
Age: 60
Compensation as of Fiscal Year 2015.

Mersana Therapeutics, Inc. Key Developments

Mersana Therapeutics, Inc. Presents at Wedbush PacGrow Healthcare Conference 2015, Aug-12-2015 03:40 PM

Mersana Therapeutics, Inc. Presents at Wedbush PacGrow Healthcare Conference 2015, Aug-12-2015 03:40 PM. Venue: Le Parker Meridian, 119 West 56th Street, New York, NY 10019, United States.

Mersana Therapeutics, Inc. Presents at Sachs Immuno-Oncology: BD&L and Investment Forum, May-29-2015

Mersana Therapeutics, Inc. Presents at Sachs Immuno-Oncology: BD&L and Investment Forum, May-29-2015. Venue: Hyatt Chicago Magnificent Mile, Chicago, Illinois, United States. Presentation Date & Speakers: May-29-2015, Eva M. Jack, Chief Business Officer.

Mersana Therapeutics, Inc. Announces Preclinical Data for its Lead Product Candidate, XMT-1522

Mersana Therapeutics, Inc. announced that preclinical data for its lead product candidate, XMT-1522, demonstrated significant anti-cancer activity in low HER2-expressing tumor models refractory to currently available therapies, as well as HER2-amplified tumor models in combination with trastuzumab-based therapies. These data will be presented at the American Association for Cancer Research (AACR) Annual Meeting on April 21 in Philadelphia, PA. XMT-1522 is a novel HER2-targeting therapy based on Mersana's Fleximer® immunoconjugate technology that carries an average of 15 proprietary auristatin payload molecules. The conjugate, optimized for payload delivery, utilizes a novel HER2-targeted antibody, which binds to a different epitope than existing anti-HER2 antibodies. Single doses of 1 mg/kg or 0.67 mg/kg of XMT-1522 showed complete regression in low HER2-expressing breast and gastric cancer models, where ado-trastuzumab emtansine was inactive at doses of 10 mg/kg and above. In HER2-driven tumor models, XMT-1522 showed synergistic efficacy in combination with widely used anti-HER2 therapies trastuzumab and pertuzumab. XMT-1522 demonstrated an excellent pharmacokinetic profile and was well tolerated in non-human primates at therapeutic doses.

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