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July 05, 2015 11:47 AM ET


Company Overview of Aerpio Therapeutics, Inc.

Company Overview

Aerpio Therapeutics, Inc., a clinical-stage biopharmaceutical company, engages in the development of therapies for the treatment of diabetic eye disease and inflammatory bowel disease. It offers tie-2 activators and HIF-1 stabilizers. The company was incorporated in 2011 and is based in Cincinnati, Ohio.

9987 Carver Road

Suite 420

Cincinnati, OH 45242

United States

Founded in 2011





Key Executives for Aerpio Therapeutics, Inc.

Chief Executive Officer and Director
Chief Financial Officer and Vice President
Age: 56
Chief Medical Officer
Age: 60
Chief Scientific Officer
Compensation as of Fiscal Year 2015.

Aerpio Therapeutics, Inc. Key Developments

Aerpio Therapeutics, Inc. Presents at Needham & Company's 14th Annual Healthcare Conference, Apr-14-2015 10:20 AM

Aerpio Therapeutics, Inc. Presents at Needham & Company's 14th Annual Healthcare Conference, Apr-14-2015 10:20 AM. Venue: Westin Grand Central Hotel, New York, New York, United States. Speakers: Joseph H. Gardner, Chief Executive Officer and Director.

Aerpio Therapeutics Announces Publication of Positive Results of Phase 1b/2a Clinical Trial of Novel Tie2 Activator, AKB-9778

Aerpio Therapeutics, Inc. announced publication of positive results from the company's Phase 1b/2a clinical study of lead clinical candidate, AKB-9778, a Tie2 activator. AKB-9778 is a first-in-class inhibitor of human protein tyrosine phosphatase beta (HPTPβ) that activates the Tie2 pathway to promote vascular stability, preventing abnormal blood vessel growth and vascular leakage. The Phase 1b/2a study, named TIME-1, showed that AKB-9778, administered subcutaneously for 28 days as monotherapy in patients with DME, was well-tolerated and produced clinically meaningful reductions in retinal thickness, correlating with improved visual acuity. The TIME-1 clinical results have been published in an article titled, Treatment of Diabetic Macular Edema with an Inhibitor of Vascular Endothelial-Protein Tyrosine Phosphatase That Activates Tie2. A total of 24 patients with DME participated in the 28-day, open-label, dose-escalation Phase Ib/2a trial. Cohorts of six patients each were treated with 5 mg, 15 mg, 22.5 mg and 30 mg of AKB-9778 delivered subcutaneously BID for 28 days, and patients were observed for an additional 56 days. As previously reported, all dose levels of AKB-9778 were well-tolerated, with no serious adverse events observed. After one month of treatment at doses of 15 mg or greater, 7 out of 18 patients demonstrated a reduction in central subfield thickness (CST) in the study eye of greater than 50µm, and 13 out of 18 patients gained 5 or more letters of visual acuity in the study eye as measured by the best corrected visual acuity (BCVA) assessment.

Aerpio Therapeutics Announces Publication of Preclinical Data on AKB-9778 for Common Eye Diseases

Aerpio Therapeutics, Inc. announced the publication of preclinical data demonstrating that lead candidate, AKB-9778, reduces abnormal blood vessel growth and leakage in mouse models of ophthalmic diseases, such as diabetic macular edema (DME) and age-related macular degeneration. These data were published in collaboration with researchers at Johns Hopkins School of Medicine, Max Planck Institute, and Duke University in the September 2, 2014, issue of The Journal of Clinical Investigation. AKB-9778 is a small molecule activator of Tie2 currently in a Phase 2 clinical study for the treatment of DME. The results of the JCI study clearly demonstrate the potential benefit of restoring Tie2 activation in mouse models of major vision-robbing eye diseases. Importantly, the results support the benefit of AKB-9778 as either a monotherapy or as an adjunct to anti-VEGF agents.

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