January 23, 2017 4:54 AM ET


Company Overview of Aerpio Therapeutics, Inc.

Company Overview

Aerpio Therapeutics, Inc. operates as a biopharmaceutical company that focuses on the development of novel therapeutics for vascular disorders. It offers therapeutics for the treatment of diabetic macular edema and inflammatory bowel diseases. The company was incorporated in 2011 and is based in Cincinnati, Ohio.

9987 Carver Road

Suite 420

Cincinnati, OH 45242

United States

Founded in 2011





Key Executives for Aerpio Therapeutics, Inc.

Chief Executive Officer, President and Director
Chief Medical Officer
Vice President of Medical Affairs
Vice President of Clinical Science
Chief Scientific Officer
Compensation as of Fiscal Year 2016.

Aerpio Therapeutics, Inc. Key Developments

Aerpio Therapeutics, Inc. Presents at 15th Annual Needham Healthcare Conference, Apr-12-2016 10:00 AM

Aerpio Therapeutics, Inc. Presents at 15th Annual Needham Healthcare Conference, Apr-12-2016 10:00 AM. Venue: The Westin NY Grand Central Hotel, 212 East 42nd Street, New York, NY 10017, United States.

Aerpio Therapeutics, Inc. Announces Positive Results of AKB-9778 in Patients with Diabetic Retinopathy from TIME-2 Phase 2a Study

Aerpio Therapeutics, Inc. announced promising results in diabetic retinopathy from the company’s phase 2a study (TIME-2) of its lead candidate, AKB-9778, a first-in-class Tie2 activator. AKB-9778, dosed at 15 mg BID subcutaneously, alone and in combination with Lucentis® (ranibizumab injection dosed at 0.3 mg intravitreally), improved underlying retinopathy according to pre-specified analyses by 2 or more steps on the diabetic retinopathy severity scale (DRSS) in the study eye at month 3. Rates of 2-step improvement were 10.0%, and 11.4% in the AKB-9778 monotherapy and AKB-9778+Lucentis combination therapy arms, respectively, compared to 8.8% of patients receiving Lucentis® alone. Further, in the fellow eye, patients that were exposed to systemic AKB-9778 achieved a 2-step or greater DRSS improvement at 3 months in 11.4% of patients, versus 4.2% of patients receiving placebo. The clinical findings were presented by Pravin U. Dugel, M.D., at the Angiogenesis, Exudation, and Degeneration 2016 meeting, which took place in Miami, FL, on February 6, 2016.

Aerpio Therapeutics Inc. Appoints Steve Pakola as Chief Medical Officer

Aerpio Therapeutics Inc. has named a new chief medical officer. The company has named Dr. Steve Pakola to the newly created role. Pakola will lead the advancement of company's development pipeline and report to president and CEO Joseph Gardner, effective immediately. Pakola was most recently chief medical officer at Amakem. He was previously chief medical officer at ThromboGenics NV, where he was the lead inventor and developer of the company's main product. His other previous roles include senior-level clinical development positions at Boehringer Ingelheim Pharmaceuticals Inc., Quintiles and Organon Inc.

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