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April 26, 2015 6:33 PM ET

Pharmaceuticals

Company Overview of Cerecor, Inc.

Company Overview

Cerecor, Inc., a biopharmaceutical company, engages in the discovery, development, and commercialization of prescription pharmaceuticals. The company focuses on human brain and nervous system. Its products include translational medicines, products for cough, and inhibitors for schizophrenia. The company was incorporated in 2011 and is based in Baltimore, Maryland.

2400 Boston Street

Suite 324

Baltimore, MD 21224

United States

Founded in 2011

Phone:

410-522-8707

Key Executives for Cerecor, Inc.

Co-Founder, Chief Executive Officer and Director
Founder and Director
Age: 64
Founder and Chairman of Scientific Advisory Board
Age: 75
Founder and Member of Scientific Advisory Board
Age: 49
Chief Financial Officer
Compensation as of Fiscal Year 2014.

Cerecor, Inc. Key Developments

Cerecor, Inc. Provides Update on CERC-301 Development in Major Depressive Disorder

Cerecor, Inc. announced the results of an exploratory inpatient pharmacokinetic/pharmacodynamic (PK/PD) study and the results of a Phase 2 outpatient efficacy study of CERC-301 for the adjunctive treatment of patients with major depressive disorder (MDD), who had recently experienced suicidal ideation. The PK/PD study provided evidence of safety and tolerability at daily doses up to 20mg, providing the basis for future efficacy studies at doses greater than 8mg. In the Phase 2 study, CERC-301 was administered daily at a dose of 8mg for 28 days and did not meet its primary endpoint of a change in the Hamilton Depression Rating Scale at day 7. CERC-301 is an oral, selective NMDA receptor subunit (NR2B) antagonist, which is thought to provide a rapid onset of antidepressant effect without the undesirable intoxication and hallucinations of non-selective NMDA receptor antagonists. In both studies, CERC-301 was well-tolerated and did not induce these untoward effects. The 135 patient, placebo-controlled Phase 2 study was designed to assess CERC-301 as adjunctive treatment for patients with MDD, who had failed to adequately respond to current selective serotonin reuptake inhibitor (SSRI) or serotonin-norepinephrine reuptake inhibitor (SNRI) treatment, had recent active suicidal ideation, and were deemed appropriate for an out-patient study. The safety and efficacy of 8mg of CERC-301 per day were evaluated over 28 days of treatment, with the primary endpoint of the change in the Hamilton Depression Rating Scale at day 7. In the PK/PD study, 48 patients were enrolled, and CERC-301 was well-tolerated at doses up to 20mg per day. The company plans to initiate the next Phase 2 efficacy study, evaluating a higher dose and revised dosing regimen of CERC-301 in the second half of 2015.

Cerecor Purchases Rights from Eli Lilly to Develop LY2456302

Cerecor reported that it has acquired exclusive, worldwide rights from Eli Lilly and Company to develop and commercialize LY2456302, a Phase 2-ready, potent and selective kappa opioid receptor antagonist. KORs are believed to play a key role in modulating stress, mood and addictive disorders. Research also suggests that selective KOR antagonists can block both the physical and emotional symptoms of nicotine withdrawal. CERC-501 was discovered and developed by Lilly for the treatment of co-occurring disorders, defined as a patient having one or more disorders relating to substance abuse combined with one or more mental health disorders. In Phase 1 clinical studies, CERC-501 was well tolerated, penetrated the blood-brain barrier and demonstrated target engagement, as shown through PET (positron emission tomography) imaging.

Cerecor, Inc. Presents at EBD Group's Biopharm America 2014 Conference, Sep-24-2014 09:30 AM

Cerecor, Inc. Presents at EBD Group's Biopharm America 2014 Conference, Sep-24-2014 09:30 AM. Venue: Boston Marriott Copley Place, 110 Huntington Avenue, Boston, MA 02116, United States.

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