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September 03, 2015 7:58 AM ET

Biotechnology

Company Overview of Autifony Therapeutics Limited

Company Overview

Autifony Therapeutics Limited, a biotechnology company, develops medicines to treat hearing disorders such as hearing loss and tinnitus. The company was incorporated in 2011 and is based in London, United Kingdom.

90 High Holborn

Holborn

London,  WC1V 6XX

United Kingdom

Founded in 2011

Key Executives for Autifony Therapeutics Limited

Chief Executive Officer
Co-Founder and Head of Preclinical Drug Discovery
Compensation as of Fiscal Year 2015.

Autifony Therapeutics Limited Key Developments

Autifony Therapeutics Limited Presents at Bio-Trinity, May-13-2015 02:30 PM

Autifony Therapeutics Limited Presents at Bio-Trinity, May-13-2015 02:30 PM. Venue: Novotel London West, 1 Shortlands, London W6 8DR, United Kingdom. Speakers: Barbara Domayne-Hayman, CBO.

Autifony Therapeutics Recruits First Trial Patient

Imperial Innovations Group plc announced that portfolio company Autifony Therapeutics (Autifony or the Company) has announced that it has recruited the first subject in a Phase IIa study for treatment of age-related hearing loss. This study (called CLARITY-1) will explore the potential of Autifony's lead product AUT00063, to improve hearing in the elderly by focusing on the discrimination of speech from background noise. The study will be conducted in around 14 key sites across the USA. Age-related hearing loss is an area of significant unmet medical need affecting up to half of people over the age of 65. For some the onset can occur well before that time; with the UK charity Action on Hearing Loss estimating that 40% of over 50 year olds have some form of hearing loss. The key complaint for those suffering from age-related hearing loss is difficulty understanding speech, in particular in noisy environments, or where several people are talking at the same time, such as at social gatherings. There are no current treatment options and whilst hearing aids or cochlear implants can help some sufferers, interpreting speech remains a challenge. AUT00063 is a novel, first-in-class Kv3 potassium channel modulator and is also in development for the treatment of tinnitus, with a Phase IIa clinical trial in this indication already underway in the UK.

Autifony Therapeutics Announces Initiation of Phase IIa Study for First-In-Class Drug to Treat Tinnitus

Autifony Therapeutics Limited has initiated a Phase IIa study in tinnitus subjects with its lead compound AUT00063. This proof of concept study (called the QUIET-1 study, QUest In Eliminating Tinnitus) will explore the potential of AUT00063, Autifony’s first-in-class Kv3 potassium channel modulator, to reduce the symptoms of tinnitus, which is an area of significant unmet medical need. In the earlier Phase I study, AUT00063 showed a good safety and tolerability profile, and pharmacokinetics compatible with once daily oral dosing. The Phase IIa study will focus in particular on tinnitus associated with hearing loss following noise exposure or ageing. Subjects will undergo four weeks of once daily dosing. In the earlier Phase I study, AUT00063 showed a good safety and tolerability profile, and pharmacokinetics compatible with once daily oral dosing. The Phase IIa study will focus in particular on tinnitus associated with hearing loss following noise exposure or ageing. Subjects will undergo four weeks of once daily dosing. AUT00063 is also in development for the treatment of age-related hearing loss and a Phase IIa clinical trial in this indication is expected to start soon in the US.

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