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December 01, 2015 10:48 PM ET


Company Overview of MedImmune, LLC

Company Overview

MedImmune, LLC, a biologics research and development company, researches, develops, and explores medicines for unmet medical needs across therapeutic areas, including respiratory, inflammation, and autoimmunity; cardiovascular and metabolic disease; oncology; neuroscience; and infection and vaccines worldwide. It offers Synagis (palivizumab), a monoclonal antibody to prevent serious lower respiratory tract disease; FluMist Quadrivalent (Influenza Vaccine Live, Intranasal), a quadrivalent influenza vaccine; and Trivalent FluMist (T/LAIV), a live attenuated influenza vaccine. The company was incorporated in 1987 and is based in Gaithersburg, Maryland with locations in Mountain View, Santa Clar...

One MedImmune Way

Gaithersburg, MD 20878

United States

Founded in 1987

2,359 Employees





Key Executives for MedImmune, LLC

Vice President of Finance
Chief Operating Officer
Vice President, Head of Antibody Discovery and Protein Engineering and Global Head of Technology
Senior Vice President of Biopharmaceutical Development
Age: 60
Executive Vice President
Compensation as of Fiscal Year 2015.

MedImmune, LLC Key Developments

MedImmune, LLC Enters into Licensing Agreement with Tanabe Research Laboratories

MedImmune, LLC and Tanabe Research Laboratories U.S.A., Inc. (TRL) have entered into a strategic collaboration and licensing agreement under which TRL will use MedImmune's pyrrolobenzodiazepine (PBD)-based warhead and linker technology to generate monospecific and bispecific antibody-drug conjugates (ADCs) for investigation in various cancers. Under the agreement, TRL will exclusively license MedImmune's next generation PBDs. The companies will partner to combine MedImmune's PBD technology with TRL's antibodies to develop next generation ADCs against a number of cancer targets. MedImmune will receive an upfront payment, development and commercial milestone payments, as well as single digit royalties on worldwide net sales. MTPC will be responsible for the pre-clinical research, development, manufacturing and later-stage activities, including global commercialization. MedImmune has the option to an exclusive license for the development and commercialization of the programs in the US and Europe at the conclusion of a Phase Ib trial.

Medimmune and 3M Drug Delivery Systems Announce Research Collaboration to Develop Novel TLR Agonist Cancer Therapies

MedImmune announced a research collaboration focused on developing next generation toll-like receptor (TLR) agonists - promising agents that activate innate immune cells and enhance the visibility of cancer tumors. As part of the agreement, MedImmune has in-licensed from 3M MEDI9197 (formerly 3M-052), a novel TLR 7/8 dual agonist. The U.S. Food and Drug Administration recently accepted an investigational new drug application (IND) for a Phase I study to explore the safety and tolerability of MEDI9197 as a potential treatment for patients with solid tumors. TLR agonists are promising agents that activate antigen presenting cells such as dendritic cells, enhancing the visibility of a tumor to the immune system. MEDI9197 has been designed to activate a broad range of innate immune cells through targeting of both TLR 7 and 8, leading to a more robust adaptive immune response. A TLR7 and 8 dual agonist can additionally convert immune suppressive cells in the tumor to those with anti-tumor properties, allowing the generation of an effective anti-tumor response. MEDI9197 will also be the first dual TLR7and 8 agonist administered directly into a tumor in a clinical setting. Preclinical studies demonstrate that intratumoral dosing of MEDI9197 may inhibit tumor growth of both the injected and distant lesions in multiple types of cancer, including melanoma. MEDI9197 is uniquely designed for intratumoral injection, allowing the compound to be retained in the tumor and provide specific immune activation, enhancing its safety and tolerability profile. Under the agreement, MedImmune is responsible for the clinical development and strategy for MEDI9197. 3M will continue to develop additional TLR agonists in oncology and other therapy areas, with MedImmune holding exclusive rights to conduct research on new molecules resulting from the collaboration and to determine which to progress to clinical development. The terms of the agreement include an upfront payment and development-related milestone payments for MEDI9197 in addition to research funding paid by MedImmune to 3M. 3M retains the rights to 3M-052 in certain topical applications and use in vaccine admixtures.

MedImmune Enters License Agreement with Daiichi Sankyo Company, Ltd for Development and Commercialization of Flumist in Japan

AstraZeneca announced that its global biologics research and development arm, MedImmune, has entered an agreement granting Daiichi Sankyo Company Ltd. (Daiichi Sankyo) an exclusive license to develop and commercialise FluMistĀ® Quadrivalent in Japan. FluMist Quadrivalent is a live attenuated influenza vaccine which is administered as a nasal spray and contains four protective strains. Phase III safety and efficacy studies were conducted for FluMist Quadrivalent in Japanese children over the 2014-2015 influenza season and a regulatory submission is being prepared in Japan. Under the terms of the agreement, Daiichi Sankyo will pay AstraZeneca an upfront fee with subsequent development milestones and sales-related payments post launch. Daiichi Sankyo will take on the full responsibility for the future development and commercialisation of FluMist Quadrivalent in Japan and will hold the marketing authorisation; AstraZeneca will supply FluMist Quadrivalent to Daiichi Sankyo.

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