March 02, 2015 2:07 PM ET

Biotechnology

Company Overview of Chroma Therapeutics Ltd.

Company Overview

Chroma Therapeutics Ltd. operates as a biotechnology company. The company focuses on chromatin biology and novel drug accumulation approaches to discover and develop cancer and inflammation treatments, and small molecule drugs. The company was incorporated in 2000 and is based in Abingdon, United Kingdom.

93 Innovation Drive

Milton Park

Abingdon,  OX14 4RY

United Kingdom

Founded in 2000

Phone:

44 1235 829120

Fax:

44 1235 829125

Key Executives for Chroma Therapeutics Ltd.

Chief Executive Officer and Director
Age: 45
Founder,Chairman of Scientific Advisory Board and Director
Founder and Member of Scientific Advisory Board
Age: 56
Founder and Member of Scientific Advisory Board
Chief Medical Officer
Compensation as of Fiscal Year 2014.

Chroma Therapeutics Ltd. Key Developments

CTI Acquires Exclusive Worldwide License to Tosedostat Through Concurrent Transactions with Vernalis R&D Limited and Chroma Therapeutics Ltd

CTI BioPharma Corp. announced that it has acquired worldwide rights to tosedostat through concurrent transactions with Vernalis R&D Limited and Chroma Therapeutics Ltd. Tosedostat is a first-in-class selective inhibitor of aminopeptidases, which are required by tumor cells to provide amino acids necessary for growth and tumor cell survival. Tosedostat is currently being evaluated in multiple Phase 2 clinical trials for the treatment of patients with Acute Myeloid Leukemia (AML) or high-risk Myelodysplastic Syndrome (MDS), which are intended to inform the design for a Phase 3 registration study to support potential regulatory approval. Over the next year, CTI and its advisors intend to develop a registration path for tosedostat in the US and Europe. Chroma and CTI also terminated their prior license agreement relating to tosedostat, thereby eliminating potential future developmental and sales milestone payments by CTI of up $209 million thereunder. Concurrently, CTI entered into a license agreement with Vernalis for the exclusive worldwide right to use certain patents and other intellectual property rights to develop, market and commercialize tosedostat and certain other analogues. Under the Vernalis license agreement, CTI agreed to make tiered royalty payments of no more than a high single-digit percentage, on a country-by-country basis, for the longer of ten years following commercial launch or the expiration of relevant patents.

Cell Therapeutics, Inc. and Chroma Therapeutics Ltd. Announces Results from the Opal Phase 2 Study of Tosedostat in Elderly Patients with Relapsed or Refractory Acute Myeloid Leukemia

Cell Therapeutics, Inc. and Chroma Therapeutics Ltd. announced that Lancet Oncology has published results from the OPAL Phase 2 study of tosedostat in elderly patients with relapsed or refractory acute myeloid leukemia (AML). Tosedostat is an oral aminopeptidase inhibitor which has been shown to deprive tumor cells of the amino acid building blocks they need to make proteins necessary for tumor cell survival. The lead author was Dr. Jorge Cortes, Professor of Medicine and Internist, Department of Leukemia, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center in Houston, Texas. The trial showed that once-daily oral tosedostat resulted in a disease control rate of 51%. Subset analyses suggested the greatest benefit occurred in the difficult-to-treat patients with prior myelodysplastic syndrome (MDS) or those that had received prior hypomethylating therapy (HMA). Adverse events were mild, predictable and manageable.

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Recent Private Companies Transactions

Type
Date
Target
Merger/Acquisition
October 27, 2014
Chroma Therapeutics Ltd., Worldwide Rights to Tosedostat
 

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