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July 30, 2015 1:42 PM ET

Biotechnology

Company Overview of RxGen, Inc.

Company Overview

RxGen, Inc. operates as a translational research company. It develops in vivo disease models to evaluate, select, and develop candidate therapeutics and drug delivery technologies. The company offers preclinical research models and services focusing on central nervous system, ophthalmic, and metabolic disorders. RxGen, Inc. is based in Hamden, Connecticut.

100 Deepwood Drive

Hamden, CT 06517

United States

Phone:

203-498-9706

Fax:

203-776-2893

Key Executives for RxGen, Inc.

Chief Executive Officer, Chief Scientific Officer, and Co-Founder
Vice-President, Chief Business Officer, and Co-Founder
Compensation as of Fiscal Year 2015.

RxGen, Inc. Key Developments

RxGen and ProLynx Present Data on Ocular Delivery Platform

RxGen and ProLynx LLC, presented primate study data showing that polyethylene glycols (PEGs) are appropriate supports to extend ocular pharmacokinetics of conjugated drugs at the Association for Research in Vision and Ophthalmology (ARVO) 2014 annual meeting in Orlando, FL. The study, performed in healthy adult African green monkeys, first evaluated the pharmacokinetics of intravitreally delivered fluorescein-labeled 20- to 80-kDa linear PEGs, and two, three and four arm 40 kDa PEGs. The fluorescein-PEG conjugates exhibited prolonged retention with half-lives of about five days that was not highly dependent on PEG size or shape, and had no apparent adverse effects. With the identification of PEGs as appropriate carrier molecules for ocular delivery ProLynx self-cleaving linkers were then used to attach fluorescent drug surrogates to demonstrate slow, controlled intravitreal release of the drug surrogate from the PEG support over time.

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