July 24, 2017 7:28 PM ET


Company Overview of Kadmon Holdings, Inc.

Company Overview

Kadmon Holdings, Inc., a biopharmaceutical company, discovers, develops, and commercializes small molecules and biologics within autoimmune and fibrotic, oncology, and genetic diseases. The company markets and distributes a portfolio of branded generic ribavirin products for chronic hepatitis C virus infection; and distributes products in various therapeutic areas, including those indicated for the management of rare diseases. Its lead product candidates include KD025, a rho-associated coiled-coil kinase2 inhibitor, which is in Phase II clinical studies for the treatment of autoimmune, fibrotic, and neurodegenerative diseases; Tesevatinib, an oral tyrosine kinase inhibitor that is in Phase I...

450 East 29th Street

New York, NY 10016

United States

111 Employees





Key Executives for Kadmon Holdings, Inc.

Chief Executive Officer, President and Director
Age: 64
Total Annual Compensation: $1.0M
Chief Financial Officer and Executive Vice President
Age: 33
Total Annual Compensation: $600.0K
Chief Administrative, Compliance & Legal Officer, Executive Vice President and General Counsel
Age: 49
Total Annual Compensation: $600.0K
Compensation as of Fiscal Year 2016.

Kadmon Holdings, Inc. Key Developments

Kadmon Holdings, Inc. - Special Call

Research and Development Day

Kadmon Holdings, Inc. Announces Interim Phase 2 Data of KD025 in Chronic Graft-Versus-Host Disease

Kadmon Holdings, Inc. announced positive interim results from its ongoing Phase 2 clinical trial evaluating KD025, the Company’s Rho-associated coiled-coil kinase 2 (“ROCK2”) inhibitor, in patients with previously treated chronic graft-versus-host disease (“cGVHD”), a serious complication following allogeneic bone marrow or stem cell transplantation. In a preliminary analysis, KD025 demonstrated a favorable safety and tolerability profile in all patients and an overall response rate (“ORR”) of 71%. KD025-208 is an ongoing Phase 2 clinical trial evaluating the safety, tolerability and activity of KD025 in adults with steroid-dependent or steroid-refractory cGVHD and active disease. The dose-finding study includes 48 patients divided into three cohorts at different dose levels (KD025 200 mg QD, 200 mg BID and 400 mg QD), enrolled sequentially following a safety assessment of each cohort. In a preliminary analysis of data from the first cohort, KD025 200 mg QD (n=17), KD025 demonstrated clinically meaningful responses in cGVHD patients, with an ORR of 71% (12/17), which includes complete and partial responders. Of responders remaining on KD025 through week 24, 7 of 8 (88%) sustained responses. In addition to the 12 responders, two patients have stable disease and remain on KD025 through week 24. Overall clinical benefit (response and stable disease) occurred in 82% (14/17) of patients. 67%; 8/12 of responders saw an improvement in symptoms as measured by the Lee cGVHD Symptom Scale score. To date, no drug-related serious adverse events (SAEs) have been recorded, and no drug-related elevations in liver function tests have been observed. Importantly, 67% (8/12) of responders had reduction of steroid doses and 67% (4/6) of patients had reduction of tacrolimus doses.

Kadmon Holdings, Inc. Presents at JMP Securities Life Sciences Conference 2017, Jun-20-2017

Kadmon Holdings, Inc. Presents at JMP Securities Life Sciences Conference 2017, Jun-20-2017 . Venue: St. Regis Hotel, 2 East 55 Street, New York, New York, United States.

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Recent Private Companies Transactions

Private Placement
March 8, 2017

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