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May 25, 2015 10:10 PM ET

Life Sciences Tools and Services

Company Overview of Pacific Biosciences of California, Inc.

Company Overview

Pacific Biosciences of California, Inc. designs, develops, manufactures, and markets an integrated platform for genetic analysis. The company provides single molecule real-time (SMRT) technology platform, which enables single molecule real-time detection of biological processes. It offers PacBio RS II high resolution genetic analyzer, an instrument that conducts, monitors, and analyzes single molecule biochemical reactions in real time. The company provides consumable products, which include sealed and packaged SMRT Cells, as well as various reagent kits, such as template preparation kits, binding kits, and sequencing kits to run the PacBio RS II. Its customers include research institutions,...

1380 Willow Road

Menlo Park, CA 94025

United States

Founded in 2000

344 Employees

Phone:

650-521-8000

Key Executives for Pacific Biosciences of California, Inc.

Executive Chairman, Chief Executive Officer and President
Age: 65
Total Annual Compensation: $1.0
Chief Financial Officer, Principal Accounting Officer and Executive Vice President
Age: 60
Total Annual Compensation: $1.0
Senior Vice President of Market Development
Age: 55
Total Annual Compensation: $399.0K
Senior Vice President of Research and Development
Age: 63
Total Annual Compensation: $399.0K
Compensation as of Fiscal Year 2014.

Pacific Biosciences of California, Inc. Key Developments

Pacific Biosciences of California, Inc. Reports Unaudited Consolidated Earnings Results for the First Quarter Ended March 31, 2015

Pacific Biosciences of California, Inc. reported unaudited consolidated earnings results for the first quarter ended March 31, 2015. For the quarter, the company reported total revenue of $17,645,000 compared to $11,642,000 a year ago. Operating loss was $19,328,000 compared to $18,245,000 a year ago. Net loss was $20,173,000 or $0.27 per basic and diluted share compared to $18,886,000 or $0.28 per basic and diluted share a year ago.

Pacific Biosciences of California, Inc. and RainDance Technologies, Inc. Partner to Co-Develop and Commercialize Novel Solution For de novo Whole Genome Assembly

Pacific Biosciences of California, Inc. and RainDance Technologies, Inc. announced their entry into a co-development and co-marketing agreement to commercialize novel solutions for de novo whole genome assembly. These solutions will combine the power of RainDance's proprietary digital droplet technology and single-molecule barcoding capabilities with Pacific Biosciences' proprietary long-range DNA amplification technology to provide sample preparation upstream of PacBio's long-read sequencing system. This combination could provide a method to generate millions of long, single-molecule barcoded DNA fragments, averaging 10-30 kilobases that originated from much longer (100 kilobase) fragments. Combining this fragmentation and labeling scheme with a sequence context-unbiased amplification method for long DNA fragments, PacBio sequencing could provide de novo, haplotype-phased assembly of complex genomes. This would be possible even in genomic regions containing complex repeats or PCR-challenged sequences that limit performance of synthetic long-read approaches based upon short-read sequencing technologies. Furthermore, this approach will be designed to work with low DNA input as little as 1 ng to address scarce or difficult-to-procure samples.

Pacific Biosciences Introduces New Solutions for Comprehensive and Efficient Targeted Sequencing and Multiplexing of Samples

Pacific Biosciences of California, Inc. announced the introduction of several new solutions for targeted sequencing applications. The company has introduced a new workflow that combines Roche NimbleGen's SeqCap EZ enrichment technology with large DNA fragments (up to 6 kb) and PacBio's Single Molecule, Real-Time (SMRT®) Sequencing to provide a more comprehensive view of variants, transgene integration sites, and haplotype information over multi-kilobase contiguous regions. The long fragments capture haplotype information that provide a more inclusive view of the targeted region of interest, allowing a comprehensive look at variants in exons, introns and intergenic regions, as well as generation of accurate haplotypes. PacBio also announced the launch of two multiplexing workflows and associated products for barcoding samples prior to running on SMRT Cells. The new barcoding kits allow customers to pool many samples and thus reduce the cost per sample and the total time for sample preparation. By employing the barcoding strategies, researchers can efficiently focus on even more defined genomic regions. And by barcoding samples, researchers have the flexibility to multiplex samples or targets within a sample or a combination of both.

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