Bloomberg Anywhere Remote Login Bloomberg Terminal Demo Request


Connecting decision makers to a dynamic network of information, people and ideas, Bloomberg quickly and accurately delivers business and financial information, news and insight around the world.


Financial Products

Enterprise Products


Customer Support

  • Americas

    +1 212 318 2000

  • Europe, Middle East, & Africa

    +44 20 7330 7500

  • Asia Pacific

    +65 6212 1000


Industry Products

Media Services

Follow Us

November 30, 2015 9:11 AM ET


Company Overview of LoneStar Heart, Inc.

Company Overview

LoneStar Heart, Inc., a biomedical company, develops cardiac restorative therapies for patients with heart failure. It develops a portfolio of device and drug based programs for congestive heart failure. The company develops Algisyl LVR, a self-gelling implantable biopolymer that is implanted in the heart for preventing or reversing the progression of advanced heart failure in patients who have an enlarged left ventricle as a result of a myocardial infarct, mitral valve regurgitation, ischemia, arrhythmias, and other disorders; and Isoxazoles, small molecule drugs for the treatment of heart failure. The company also develops cell reprogramming cardiac fibroblasts for the regeneration of card...

26051 Merit Circle

Suite 102

Laguna Hills, CA 92653

United States

Founded in 2010





Key Executives for LoneStar Heart, Inc.

President, Chief Operating Officer and Director
Founder and Executive Chairman
Age: 65
Founder, Chief Scientific Advisor and Director
Age: 75
Vice President of Clinical & Regulatory Affairs
Age: 52
Compensation as of Fiscal Year 2015.

LoneStar Heart, Inc. Key Developments

LoneStar Heart, Inc. Reports Successful One-Year Results of Randomized Clinical Trial on Efficacy of Algisyl® in the Treatment of Heart Failure

LoneStar Heart, Inc. presented and published the one-year extended follow-up results of AUGMENT-HF, an international randomized, multi-center clinical trial to evaluate the safety and efficacy of Algisyl. Classified as a medical device, Algisyl is a novel hydrogel that is implanted into specific areas of the failing heart muscle to improve cardiac function and clinical symptoms in advanced heart failure patients. Algisyl is approved for use in the European Union. The U.S. Food and Drug Administration recently approved an Investigational Device Exemption that allows the company to initiate a pivotal clinical study of Algisyl in the United States subject to certain conditions. The presentation was given by Douglas L. Mann, M.D., Professor and Chief, Cardiovascular Division of Washington University School of Medicine and Cardiologist-in-Chief, Barnes Jewish Hospital, St. Louis, Mo., at the late-breaking trials session of the annual meeting of the Ameri­can Heart Association held in Orlando. The study compared the safety and efficacy of Algisyl combined with standard medical therapy to standard medical therapy alone. The primary endpoint of efficacy is peak VO2, a measure of maximal aerobic capacity that is considered the best indicator of cardiovascular health because it correlates strongly with clinical symptoms, morbidity and mortality. Patients treated with Algisyl had a significant improvement at 12 months where the mean treat­ment effect was an increase of 2.10 mL/kg/min (95% confidence interval, CI 0.96–3.24, P < 0.001) vs controls. This result represents a sizeable continued improvement over the 6-month data published recently where the treatment effect was 1.24 mL/kg/min. Similarly, the 6-minute walk test, another efficacy measure, showed a significant difference of 101 meters in favor of the Algisyl group. Lastly, New York Heart Association (NYHA) functional class at 12 months was significantly improved in the Algisyl group with 85% of patients observed to be in NYHA Class I or II. Among the controls, only 25% of patients were observed to be in NYHA Class II and none in Class I. The clinical trial analysis was not statistically powered to assess mortality or morbidity. At the 12-month follow-up, there were 13 deaths including 4 in the control group and 9 in the treatment group. The overall incidence of serious adverse events was not significantly different between the Algisyl and the control group. However, Algisyl patients experienced substantially lower rates of worsening heart failure (34.2% of control patients vs. 15.0% of Algisyl patients) and sustained ventricular arrhythmias (13.2% of control patients vs. 2.5% of Algisyl patients).

LoneStar Heart Receives European Approval to Market its Algisyl-LVR(R) Hydrogel Implant for the Treatment of Advanced Heart Failure

LoneStar Heart, Inc. announced that it received the CE Mark (Conformite Europeene) for its Algisyl-LVR(R) hydrogel implant, the company's lead product for the treatment of advanced heart failure (HF). Classified in Europe and in the U.S. as a medical device, Algisyl-LVR is intended to reverse HF progression in people who have an enlarged left ventricle. Surgically injected directly into the heart muscle, the hydrogel acts immediately as an internal scaffold that does not undergo long-term degradation and increases cardiac output. The CE Mark indicates a product's compliance with European Union legislation and that it can be sold throughout the European Economic Area. Six-month patient outcome studies of Algisyl-LVR will be presented at the annual meeting of the American Heart Association (AHA), November 15-19, 2014 in Chicago. The AUGMENT-HF randomized clinical trial is being conducted at 14 centers in Italy, Germany, Romania, Australia, and The Netherlands to determine if the product is superior to standard medical therapy in the management of patients with a dilated and weakened left ventricle and significantly deteriorated cardiac function.

LoneStar Heart Presents at 13th Annual BIO Investor Forum, Oct-07-2014 01:30 PM

LoneStar Heart Presents at 13th Annual BIO Investor Forum, Oct-07-2014 01:30 PM. Venue: The Palace Hotel, San Francisco, CA 94105, United States.

Similar Private Companies By Industry

Company Name Region
Evotope Biosciences, Inc. United States
Angstrom Medica, Inc. United States
Cynvec LLC United States
CellzDirect, Inc. United States
OrthoCyte Corporation United States

Recent Private Companies Transactions

No transactions available in the past 12 months.

Stock Quotes

Market data is delayed at least 15 minutes.

Company Lookup

Most Searched Private Companies

Company Name Geographic Region
Lawyers Committee for Civil Rights Under Law United States
Bertelsmann AG Europe
NYC2012, Inc. United States
Rush University United States
Citizens Budget Commission United States

Sponsored Financial Commentaries

Sponsored Links

Request Profile Update

Only a company representative may request an update for the company profile. Documentation will be required.

To contact LoneStar Heart, Inc., please visit Company data is provided by Capital IQ. Please use this form to report any data issues.

Please enter your information in the following field(s):
Update Needed*

All data changes require verification from public sources. Please include the correct value or values and a source where we can verify.

Your requested update has been submitted

Our data partners will research the update request and update the information on this page if necessary. Research and follow-up could take several weeks. If you have questions, you can contact them at