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February 14, 2016 2:23 PM ET

Life Sciences Tools and Services

Company Overview of BioAtla, LLC

Company Overview

BioAtla, LLC, a global biology outsourcing services provider, offers protein therapeutics technology and services. It provides target discovery services; and antibody evolution, engineering, and generation services that include antibody affinity maturation and functional engineering, antibody expression and purification, assay development and functional characterization, antibody internalization, antigen expression and purification, monoclonal and polyclonal antibody production, and follow-on biologics services. The company also offers Versitope system that maximizes epitope coverage, affinity, and functionality to deliver the path to discovery of immunization-induced antibodies; GigaMab, a ...

11011 Torreyana Road

San Diego, CA 92121

United States

Founded in 2007

Phone:

858-558-0708

Fax:

858-558-0701

Key Executives for BioAtla, LLC

Chairman, Chief Executive Officer, and President
Age: 57
Founder and Business Advisor
Age: 53
Vice President of Scientific Projects & Collaboration
Vice President of Scientific Projects & Collaboration
Compensation as of Fiscal Year 2015.

BioAtla, LLC Key Developments

BioAtla and Sinobioway to Collaborate on CAB Antibody Therapeutics in China

BioAtla (US) and Beijing Sinobioway (China) planned to focus on conditionally active biologic (CAB) antibody therapeutics, as the first programme of their strategic collaboration in mainland China, Hong Kong, Macau, and Taiwan. BioAtla expects to receive over USD 70 million in total programme payments and equity investment from Sinobioway over the course of the next 12 months as part of the agreement. In addition, Sinobioway holds exclusive rights to develop and commercialise the selected CAB antibodies in mainland China, Hong Kong, Macau, and Taiwan, while BioAtla retains rights to these products in the rest of the world. Meanwhile, Sinobioway will fund the development, manufacture, clinical trials, and commercialization costs in China, Taiwan, Hong Kong, and Macau, while BioAtla is also eligible to receive milestone payments and double-digit sales royalties.

BioAtla Enters into License and Option Agreement with Pfizer to Advance the Development and Commercialization of a New Class of Antibody Therapeutics

BioAtla has entered into a license and option agreement with Pfizer to advance the development and commercialization of a new class of antibody therapeutics based on BioAtla's CAB platform and utilizing Pfizer's proprietary antibody drug conjugate (ADC) payloads. Under the agreement, BioAtla and Pfizer will each have a license to the other's respective technology to pursue the development and commercialization of several CAB-ADC antibodies. Pfizer also gains an exclusive option to develop and commercialize BioAtla CAB antibodies that target CTLA4, a validated immuno-oncology target in humans. If successful, BioAtla's technology would allow the selective targeting of CTLA4 expressed on immune cells localized in the tumor microenvironment. BioAtla and Pfizer are both eligible to receive milestone payments and royalties based on individual CAB-ADC antibody candidates developed and commercialized by the other party. Including the CTLA4 option and license, BioAtla is eligible to receive a potential total of more than $1.0 billion in up-front, regulatory and sales milestone payments as well as tiered marginal royalties reaching double digits on potential future product sales. CAB-ADC antibodies aim to address the inherent limitations of current ADC antibody technology by actively binding to antigens expressed on tumor tissue-resident cancer cells, but not to the same antigens expressed on normal cells in non-diseased tissues. If successful, this approach would allow the preferential targeting of tumor tissues by ADCs, thereby increasing the efficacy-safety ratios of CAB-ADCs relative to their conventional counterparts. The use of CAB antibodies as payload delivery vehicles could increase the number of tumor-associated antigens that are addressable with ADC technology.

BioAtla, LLC Enters into Strategic License and Option Agreement with Pfizer Inc. for New Class of Antibody Therapeutics

BioAtla LLC announced that it has entered into a license and option agreement with Pfizer Inc. to advance the development and commercialization of a new class of antibody therapeutics based on BioAtla's CAB platform and utilizing Pfizer's proprietary antibody drug conjugate (ADC) payloads. Under the agreement, BioAtla and Pfizer will each have a license to the other's respective technology to pursue the development and commercialization of several CAB-ADC antibodies. Pfizer also gains an exclusive option to develop and commercialize BioAtla CAB antibodies that target CTLA4, a validated immuno-oncology target in humans. If successful, BioAtla's technology would allow the selective targeting of CTLA4 expressed on immune cells localized in the tumor microenvironment. BioAtla and Pfizer are both eligible to receive milestone payments and royalties based on individual CAB-ADC antibody candidates developed and commercialized by the other party. Including the CTLA4 option and license, BioAtla is eligible to receive a potential total of more than $1.0 billion in up-front, regulatory and sales milestone payments as well as tiered marginal royalties reaching double digits on potential future product sales. CAB-ADC antibodies aim to address the inherent limitations of current ADC antibody technology by actively binding to antigens expressed on tumor tissue-resident cancer cells, but not to the same antigens expressed on normal cells in non-diseased tissues. If successful, this approach would allow the preferential targeting of tumor tissues by ADCs, thereby increasing the efficacy-safety ratios of CAB-ADCs relative to their conventional counterparts. The use of CAB antibodies as payload delivery vehicles could dramatically increase the number of tumor-associated antigens that are addressable with ADC technology.

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