Israel’s TA-25 benchmark index is among the five worst-performing global stock exchanges as declines in drugmakers led by Teva Pharmaceutical Industries Ltd. pushed the gauge down the most in two months. Pharmaceutical companies that operate largely outside Israel make up more than a quarter of the TA-25 Index. Teva plunged the most in more than three months after losing a U.S. patent ruling, while Mylan NV, Perrigo Co. and other health companies fell amid questions about the pricing of the EpiPen.

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