July 29 (Bloomberg) -- Ebola, the killer of more than 670 people in four West African countries since February, has spread beyond Africa only once. That doesn’t mean it can’t happen now, infectious disease experts warn.
The symptoms appear from two days to three weeks after infection, meaning it’s possible for an infected person who doesn’t feel ill to board a plane, said Ben Neuman, a virologist at the University of Reading in the U.K. Since Ebola in its earliest stages can resemble nothing more than flu, no one else would know either, he said.
“One person per plane load would have something that you would possibly call flu-like symptoms,” Neuman said in a telephone interview. “Do you want to detain all those people coming into your airport? Do you have the manpower to do that, and send them all for testing? It’s expensive, and difficult.”
The question of trans-continent infection became more key this week after Patrick Sawyer, a Liberian government worker who took a July 20 flight to Lagos, Nigeria, died from Ebola five days later. His death gave Africa’s most populous nation its first case, a frightening hint at how global air travel may enable the spread of disease.
“We’ve known it’s a risk ever since the beginning of the Ebola outbreak, and now it’s finally happened,” Neuman said. “He could have gone anywhere on this flight.”
Even so, no special screening is being done at U.S. airports, Martin Cetron, director of global migration and quarantine at the U.S. Centers for Disease Control and Prevention in Atlanta, said yesterday in a telephone briefing.
Ebolavirus first appeared in 1976 in two simultaneous outbreaks: in Nzara, Sudan, and in Yambuku, Democratic Republic of Congo, according to the World Health Organization. The latter was in a village near the Ebola River, from which the disease takes its name.
There are five species of ebolavirus, three of which are associated with causing large outbreaks in Africa: Bundibugyo, Sudan and Zaire, which is responsible for the current outbreak. Tai Forest ebolavirus is known to have caused only one non-lethal human case. That was in Ivory Coast in 1994, according to a log of outbreaks by the WHO.
The fifth species -- Reston ebolavirus -- was first identified in Reston, Virginia, in 1990 and has been found in the Philippines and China. While it can infect humans, there have been no reports of it causing illness or death in people.
People who may have been in contact with the virus are generally monitored for fever for 21 days, the CDC said. Only about 50 percent of patients show extreme symptoms that can include bleeding from the eyes, ears and nose. Others have only a fever as an early symptom.
Historically, Ebola virus disease in Africa has killed as many as 90 percent of people who are infected. In this outbreak, the fatality rate is closer to 60 percent, said Stephen Monroe, deputy director at the CDC’s National Center for Emerging & Zoonotic Infectious Diseases.
Early treatment may lead to higher survival rates, the agency said. With no cure for the disease, treatment focuses on replenishing fluids, maintaining proper blood pressure, replacing lost blood, and treating related infections.
The agency is sending out a health alert to U.S. doctors and health-care providers that will focus of the importance of asking patients about their travel history and outlining the symptoms of Ebola virus disease.
Ebolavirus isn’t carried in the air like tuberculosis or flu, said David Heymann, a professor at the London School of Hygiene and Tropical Medicine. Instead it is spread by direct contact with an infected person’s blood or other bodily secretions, including vomit, saliva or feces, he said.
While an infected person who sneezes or coughs directly in another person’s face could infect that person, Ebola primarily enters the body through tiny cuts or abrasions, or through mucus membranes of the eyes, nose, ears and mouth. The physical effect of the virus makes it less likely to spread through air travel, Neuman said.
“If you look at the numbers, there are probably about 300 people currently infected with Ebola virus, and most of those would be too ill to sit up or walk,” Neuman said. “So the odds are small, but it is something that needs to be watched.”
Health workers are more at risk than fellow travelers, doctors say, along with family members who touch or kiss the body of a victim during burial rites.
Two U.S. citizens have been infected: Kent Brantly, the medical director of the Ebola center run by Samaritan’s Purse in Liberia’s capital of Monrovia, and Nancy Writebol, a worker at the center, the Boone, North Carolina-based charity said in a statement.
Both are both being treated at the center in Monrovia, and Brantly’s family, now in the states, is under fever watch there because of an “overabundance of caution,” Monroe, of the CDC, said during the briefing.
The U.S. is well prepared to handle infected patients on its soil with 20 CDC quarantine stations in place at U.S. airports that are designed to deal with anyone who has symptoms of a wide range of infectious illnesses, including Ebola, the agency has said.
The State Department is closely tracking the Ebola situation and is aware of reports about the two U.S. citizens who have been infected, said Jennifer Psaki, a department spokeswoman.
“In terms of what we’re considering, I don’t have anything to predict,” Psaki said. “We’re taking every precaution.”
The State Department is updating travel warnings as information comes available, she said.
Arik Air, a Nigerian airline, has suspended all flights to Liberia’s capital Monrovia and Sierra Leone’s capital Freetown until further notice, the Lagos-based company said yesterday in a statement. Asky Airlines, the carrier Sawyer took, also suspended flights to Freetown and Monrovia, the Togo-based carrier said in a statement handed to reporters today.
Other airlines may start taking similar measures, said John Rose, chief operating officer at iJET International Inc., which advises businesses on risk management in Africa.
“Airlines are asking the questions, ‘At what point do we consider not flying to those countries? What happens if European countries shut off air space?’” Rose said by phone. “Those are realistic scenarios.”
Government-level restrictions may also increase, including more detailed screening of arriving flight passengers and closing of borders and air space, he said.
Among global security situations iJET is monitoring, including Gaza and Ukraine, Ebola is at the forefront of the company’s concerns, Rose said. “Ebola is the one we have the least control over,” he said.
The current outbreak has killed 672 people of 1,201 reported infections in Guinea, Sierra Leone and Liberia, the WHO said in a statement. Sawyer’s death hasn’t been officially confirmed as an Ebola case by the Geneva-based agency but is being regarded as probable.
Most of the cases have been reported in the region where the three countries’ porous borders meet, and where people frequently cross without border checks, by walking or using cars, motorcycles and bicycles.
Fruit bats are thought to be the natural host of Ebola virus, according to the WHO. Monkeys, chimpanzees, gorillas, porcupines and forest antelope can also be infected, and human outbreaks can begin when people eat the meat of infected animals, according to the WHO.
The only case in which an Ebola victim was known to be taken out of Africa by aircraft came in 1994, when a 34-year-old Swiss zoologist became infected with the virus while performing an autopsy on a chimpanzee in Ivory Coast.
Eight days later, she developed chills, then diarrhea, an all-body rash, temporary memory loss and was flown to Switzerland by air ambulance for treatment, accompanied by health workers wearing masks, gloves and gowns. She recovered without infecting anyone else.
The Ebola outbreak is expected to go on for some time and will be difficult to stop as it can easily “re-ignite” from even one case, the CDC’s Monroe said. Even if there are no new cases, it would be 42 days before health workers would be sure the outbreak was over.
“The response to these outbreaks will be more of a marathon than a sprint,” Monroe said.
(An earlier version of this story corrected the name of the Ebola strain responsible for the current outbreak.)