Dec. 4 (Bloomberg) -- GlaxoSmithKline Plc said GLP-1 diabetes drugs, including its albiglutide experimental compound and Novo Nordisk A/S’s Victoza, are unlikely to win clearance to treat obesity because of effectiveness questions.
“Frankly as a class, I don’t think GLP-1s would make it as obesity medicines,” Moncef Slaoui, Glaxo’s chairman of research and development, said in an interview today in London. “Even with Victoza, personally, I would not” consider it for obesity.
Glaxo, which is based in London, plans early next year to seek regulatory approval for albiglutide, a form of a hormone called GLP-1 that stimulates the pancreas to produce more insulin, as a once-weekly diabetes treatment. Bagsvaerd, Denmark-based Novo is studying Victoza, already on the market to treat Type 2 diabetes, as a potential weight-loss medicine.
Novo said in June that patients taking Victoza lost 3.9 kilograms (8.6 pounds) on average, compared with 2.9 kilograms for those taking a competing drug.
The limited weight loss, the difficulty of sustaining results and potential side effects “would be a challenge for that medicine to be approved for obesity use,” Slaoui said.
Novo Nordisk is the world’s biggest insulin maker. Victoza, a once-daily GLP-1 drug, generated sales of 5.99 billion kroner ($1.1 billion) last year.
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