Asad Shafiq and Azhar Ali both hit half centuries for Pakistan to set England a target of 238 to win their fourth one-day cricket international in Dubai and sweep the series.
Pakistan won the toss and elected to bat, and lost Mohammad Hafeez on 1 when he was caught by Craig Kieswetter off Jade Dernbach. Pakistan recovered to 202-4, with Shafiq bowled by Tim Bresnan on 65, and Ali caught by Eoin Morgan on 58 off Dernbach. Shoaib Malik was trapped leg-before-wicket by Danny Briggs, leaving Pakistan on 202-5, and it lost the rest of the wickets for 35 runs.
Dernbach was 4-45, while Steve Finn and Briggs, making his ODI debut for England, both took two wickets.
England has already won the one-day series, having taken the first three matches. Pakistan swept their three Test matches, and the two will go on to play three Twenty20 matches.