Beyoncé Knowles: After surviving on water, maple syrup, and cayenne pepper concoctions for more than a week in 2006, the singer and actress's considerable weight loss was splashed all over tabloids—a boon for Big Cleanse.

Gwyneth Paltrow: The veteran practitioner lauded Denise Mari, founder of Organic Avenue's juice cleansing program, in her e-newsletter, Goop, because she makes "a cleanse easy with different degrees of gnarlyness."

Salma Hayek: The 44-year-old actress has been relying on juicing to be red-carpet ready for the past 15 years. In 2008 she even created Cooler Cleanse with nutritionist and longtime friend Eric Helms. Cleanses cost $58 per day.

Kathy Freston: The Quantum Wellness author, power vegan, and wife of former Viacom CEO Tom Freston famously guided Oprah Winfrey through a 21-day cleanse in 2008. Winfrey blogged: "[Freston] speaks of 'spiritual integrity.' "Well, O.K....

Zoe Sakoutis and Erica Huss Jones: The former bartenders started BluePrintCleanse in 2007 and currently run an operation employing 70 people. The company is mulling an expansion into lifestyle goods.

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