Shares of the following companies had unusual moves in U.S. trading. Stock symbols are in parentheses, and prices are as of 4 p.m. in New York.
Amylin Pharmaceuticals Inc. (AMLN US) plunged 46 percent to $11.03 for the biggest decline in the Russell 1000 Index. The maker of the diabetes treatment Byetta canceled a quarterly-update conference call because U.S. regulators denied approval for an injectable diabetes shot. JPMorgan & Chase Co. downgraded the shares to “neutral” from “overweight” and set a 12-month price target of $11.
Eli Lilly & Co. (LLY US), which markets the diabetes drug outside the U.S., slipped 3.9 percent to $36.01. Alkermes Inc. (ALKS US), maker of the technology allowing the drug to be used in longer-acting form, fell 28 percent to $10.50.
Boeing Co. (BA US) advanced 3.4 percent to $71.36 for the biggest gain in the Dow Jones Industrial Average. The 94-year-old airplane maker boosted its profit forecast because of an improved outlook in the commercial airplanes sector to as much as $4 a share, up from a range of $3.50 to $3.80 a share it initially projected. The company reported third-quarter profit of $1.12 a share, beating analysts’ average estimate of $1.07.
Boston Scientific Corp. (BSX US) had the second-biggest gain in the Standard & Poor’s 500 Index, climbing 5.5 percent to $6.30. The second-largest maker of heart devices by revenue reported third-quarter profit that topped analysts’ estimates as sales of its key heart-rhythm devices matched the upper range of analysts’ estimates.
Comerica Inc. (CMA US) had the third-biggest loss in the S&P 500, erasing 6.4 percent to $35.94. The Dallas-based bank reported third-quarter profit excluding some items of 34 cents a share, trailing the average analyst estimate by 16 percent, according to Bloomberg data.
Cree Inc. (CREE US) slid 5.5 percent, the most since Sept. 8, to $50.08. The maker of energy-efficient lighting products forecast second-quarter sales of $280 million at most. That missed the average estimate of $296.2 million from analysts in a Bloomberg survey.
Delta Air Lines Inc. (DAL US) gained 11 percent, the most since Dec. 11, to $12.97. The carrier had third-quarter adjusted earnings of $1.10 a share, topping the 94 cents forecast by analysts.
Other airlines also advanced. AMR Corp. (AMR US) climbed 13 percent to $7.34 for the biggest gain in the Russell 1000, while United Continental Holdings Inc. (UAL US) added 7.6 percent to $27.63.
FSI International Inc. (FSII US) dropped 17 percent, the most since October 2009, to $2.55. The maker of equipment for chip factories forecast first-quarter sales of $12 million at most. That trailed the $28.6 million estimated by Needham & Co.
Furniture Brands International Inc. (FBN US) declined 4 percent to $5.46, falling for a third day. The furniture retailer was cut to “underperform” from “market perform” at Raymond James Financial Inc.
Gilead Sciences Inc. (GILD US) rose 4.5 percent, the most since Jan. 27, to $38.39. The world’s largest maker of AIDS drugs posted third-quarter earnings excluding some items that beat the average analyst estimate by 3.1 percent, according to Bloomberg data.
H&R Block Inc. (HRB US) fell 1.1 percent to $10.73, the lowest price since February 2001. The biggest U.S. tax preparer had a unit downgraded by Moody’s Investors Service as a legal dispute with HSBC Holdings Plc threatened the company’s ability to offer customers refund loans next year.
Intuitive Surgical Inc. (ISRG US) dropped 7 percent to $259.45, the lowest price since Nov. 6. The surgical-system maker reported third-quarter revenue of $344.4 million, below the $349.9 million average analyst estimate from a Bloomberg survey.
J. Crew Group Inc. (JCG US) fell 5.1 percent, the most since Aug. 27, to $33.12. The clothing retailer had its third-and fourth-quarter and 2010 profit estimates cut at Needham & Co.
Lindsay Corp. (LNN US) rose 17 percent, the most since December 2008, to $57.78. The maker of GrowSmart irrigation equipment posted a fourth-quarter profit of 48 cents a share, beating the average analyst estimate by 73 percent.
Marshall & Ilsley Corp. (MI US) slid 10 percent to $6.24 for the biggest retreat in the S&P 500. Wisconsin’s largest bank posted a loss excluding some items of 32 cents a share in the third quarter, 27 percent wider than average loss estimate by analysts, according to Bloomberg data.
Massey Energy Co. (MEE US) rose 5.1 percent to $39.25, the higher price since April 29. The owner of the Upper Big Branch coal mine where 29 people died in April gained 5 percent yesterday on reports it’s considering a sale and other options.
Pinnacle Financial Partners Inc. (PNFP US) jumped 10 percent, the most since March 2009, to $11. The bank holding company reported profit of 2 cents a share in the third quarter. Analysts, on average, estimated a loss of 28 cents, according to a Bloomberg survey.
United Rentals Inc. (URI US) climbed 10 percent to $17.60, the highest price since September 2008. The largest U.S. construction-equipment rental company reported third-quarter earnings excluding some items of 40 cents a share, beating the average analyst estimate by 58 percent.
Wells Fargo & Co. (WFC US) rose 4.3 percent to $25.60 for the biggest gain in the Standard & Poor’s 500 Financials Index. The largest U.S. home lender reported record third-quarter profit that beat most analysts’ estimates as credit conditions improved, and said it’s not planning to halt foreclosures.