Diabetes Cases Rise in U.S. as Complication Rate Declines

Improved preventative care for diabetes has cut the rate of serious complications such as heart attack and stroke over the past 20 years in the U.S. while the number Americans diagnosed with the disease continues to rise, a government report found.

Diagnosed diabetes cases tripled to 20.7 million in 2010 from 6.5 million in 1990, according to research from the Centers for Disease Control and Prevention published yesterday in the New England Journal of Medicine. The jump in diagnoses resulted in more people suffering from complications despite the rate reduction, said Linda Geiss, one of the study authors.

“Although we’ve seen a decline in the rates and we’ve come a long way in preventing the complications and improving the quality of life for people with diabetes, most of the numbers are still increasing,” Geiss, head of diabetes surveillance at the CDC in Atlanta, said in a telephone interview. “We need to make some progress in preventing Type 2 diabetes in order to help decrease these numbers.”

Diabetes, which is caused when the body doesn’t use insulin properly or doesn’t make the hormone, is the seventh-leading cause of death in the U.S. Insulin is a hormone secreted by the pancreas that helps the body control blood sugar. Type 2 accounts for 90 percent to 95 percent of U.S. cases.

About 79 million Americans are at risk for developing diabetes, according to the CDC. Diabetes and the associated complications cost $176 billion in medical expenses each year.

Drug Sales

Diabetes drug sales may surpass $50 billion by 2017, according to data compiled by Bloomberg. The newest therapy, GlaxoSmithKline Plc (GSK)’s Tanzeum, won U.S. approval on April 15 to control Type 2 diabetes. Analysts’ estimate the treatment will generate $306.6 million in 2017.

The CDC report issued yesterday found the rate of heart attack among diabetics declined 68 percent in 2010 from 1990, while stroke fell 53 percent and amputations were cut 51 percent. Rates of deaths from high blood sugar and end-stage kidney failure also fell during the 20 years. The largest decline in many of the complications was seen in those ages 75 and older.

Researchers used data from the National Health Interview Survey, the National Hospital Discharge Survey, the U.S. Renal Data System and Vital Statistics to look at diabetes-related complications in the U.S. during the 20 years.

Geiss said the decline in the complication rates may reflect better medical management of people with diabetes, better self-management by those with the disease, better treatment of blood pressure and cholesterol and earlier screening for issues like kidney disease and foot ulcers.

Further Effort

“While the decline in complications is good news, they are still high and will stay with us unless we can make substantial progress in preventing Type 2 diabetes,” Edward Gregg, the lead study author and a senior epidemiologist in the CDC’s Division of Diabetes Translation, said in a statement.

The CDC has said that 25.8 million Americans have diabetes, including 7 million who haven’t been diagnosed. The report issued yesterday focused on those who know they have the condition.

Elizabeth Seaquist, president of medicine and science at the American Diabetes Association, said more studies are needed to better understand what’s being done right in the medical community to help lower diabetes complications and what more must be done to reduce the number of people who have or at risk of developing the disease.

“Diabetes is still a huge epidemic in this country and these complications are very serious and certainly not going away,” Seaquist, a professor of medicine at the University of Minnesota in Minneapolis said in a telephone interview. “We need to understand where clinical care has led to improvements. It may give us some suggestions on where we need to further our future efforts.”

To contact the reporter on this story: Nicole Ostrow in New York at nostrow1@bloomberg.net

To contact the editors responsible for this story: Reg Gale at rgale5@bloomberg.net Andrew Pollack, Angela Zimm

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