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New Bird Flu Found to Be Resistant to Roche’s Tamiflu Drug

A gene mutation known to make flu viruses resistant to Roche Holding AG (ROG)’s Tamiflu was identified in two patients infected with the H7N9 bird flu virus in China, a study found.

The gene was discovered in two of three patients who became the most severely ill in a study of 14 patients treated with Tamiflu after being admitted to a Shanghai hospital in April with H7N9 infection, according to an article published in The Lancet medical journal today. In one patient, the resistance developed after the initial infection, suggesting treatment with Tamiflu may have spurred the mutation.

The finding is the first official confirmation of resistance to Tamiflu. In the other patients, treatment with the drug was associated with clearing the virus, and early treatment of suspected or confirmed cases is “strongly encouraged,” wrote a group of researchers led by Zhenghong Yuan of Fudan University.

“The apparent ease with which antiviral resistance emerges in A/H7N9 viruses is concerning,” the researchers wrote. “It needs to be closely monitored and considered in future pandemic response plans.”

Tamiflu belongs to a class of drugs called neuraminidase inhibitors that also includes GlaxoSmithKline Plc (GSK)’s Relenza.

Photographer: Philippe Lopez/AFP via Getty Images

An official holds a chicken during the checking of poultry at the border with mainland China in Hong Kong as authorities step up measures against the spread of the deadly H7N9 bird flu virus. Close

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Photographer: Philippe Lopez/AFP via Getty Images

An official holds a chicken during the checking of poultry at the border with mainland China in Hong Kong as authorities step up measures against the spread of the deadly H7N9 bird flu virus.

“Rates of Tamiflu resistance remain low globally, although Roche takes the issue of resistance very seriously and collaborates with international organizations and authorities to monitor the situation,” Silvia Dobry, a spokeswoman for the Basel, Switzerland-based drugmaker, said in an e-mail.

To contact the reporter on this story: Simeon Bennett in Geneva at sbennett9@bloomberg.net

To contact the editor responsible for this story: Phil Serafino at pserafino@bloomberg.net

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