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Lung Cancer Genomic Mapping Yields New Targets, Researche

A form of lung cancer that kills 400,000 people annually worldwide could be attacked by targeting newly discovered genetic mutations, according to a study that mapped the tumors’ DNA.

Researchers found mutations in 11 genes from 178 squamous cell lung tumors they sequenced, including alterations previously linked to cancer growth, according to the study published yesterday in the journal Nature. The findings also included variations in a gene, called HLA-A, that helps the immune system fight off irregular tissue in the body.

“To our knowledge, this is the first example of a tumor that has a genomic mechanism for evading an immune response,” Matthew Meyerson, co-leader of the team that made the discovery, and pathology professor at Dana-Farber Cancer Institute and Harvard Medical School in Boston, said in a statement. “This provides many new therapeutic opportunities for squamous cell carcinoma that would be suitable for clinical trials.”

The findings are encouraging for patients with squamous cell lung cancer because, unlike a form known as adenocarcinoma, there are no drugs available that target the DNA mutations that drive this malignancy’s growth. Patients with the adenocarcinoma form can be given Roche Holding AG’s (ROG) Tarceva or AstraZeneca (AZN) Plc’s Iressa, which target a mutation in the EGFR gene.

The study of squamous cell lung tumors found 90 percent had an altered TP53 gene and 72 percent had an inactive CDKN2A gene, both previously identified mutations, the study said. When these genes are switched off, cancer can grow uncontrollably.

The data are part of a broader project by the National Institutes of Health called the Cancer Genome Atlas, which is analyzing tumors and blood samples from 20 types of cancer.

One of the project’s earlier studies of ovarian cancer patients with a genetic mutation best known for its ties to breast cancer have found they have a higher survival rate than those without the mutation. Another finding identified new targets in colon cancer.

To contact the reporter on this story: Ryan Flinn in San Francisco at rflinn@bloomberg.net

To contact the editor responsible for this story: Reg Gale at rgale5@bloomberg.net

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