Pfizer, Medivation End Alzheimer Drug’s Work After Failure
Dimebon was one of two drugs New York-based Pfizer had in its late-stage pipeline to treat the neurodegenerative disease. The other is bapineuzumab, which Pfizer is developing with Johnson & Johnson. The treatments have different mechanisms of action.
Dimebon didn’t show statistically significant results in a study that evaluated the compound when added to a standard treatment in patients with mild to moderate forms of the disease, the companies said today in a statement. The companies will end development of the drug for all uses, and will stop a current study.
Dimebon also failed in a late-stage trial in 2010, sending Medivation shares down 67 percent in one day.
The U.S. Centers for Disease Control and Prevention in Atlanta estimates that at least 5 million Americans have Alzheimer’s. The disease usually begins affecting people around age 60. There is no known cure.
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