Jarrod Saltalamacchia added his first homer last night for Boston (20-20), which has a .500 winning percentage for the first time since starting the Major League Baseball season with a 0-6 record.
The Yankees have lost a season-high five straight games, all at home, to fall to 20-18 overall.
“When things are going bad, they’re going bad,” Yankees manager Joe Girardi said at a news conference. “We’ve got to turn it around.”
The Yankees took a 4-1 lead after two innings on homers by Andruw Jones and Curtis Granderson.
Youkilis tied it with a three-run home run in the top of the third inning and Ortiz’s homer put the Red Sox ahead in the fifth. Yankees starting pitcher Freddy Garcia allowed five runs over 5 1/3 innings and took the loss for the third time in his past four outings.
Jon Lester allowed four runs over six innings to improve to 5-1 for Boston, which has won five of six meetings this season with the American League Eastern Division-rival Yankees.
The Red Sox last swept a three-game series in New York on April 23-25, 2004.
Jorge Posada walked as a pinch-hitter for the Yankees in the eighth inning, when he received a standing ovation from the New York crowd. Posada said he apologized to Girardi and Yankees General Manager Brian Cashman, one day after he was demoted to the ninth spot in the batting order and then took himself out of the lineup.
“I just had a bad day,” Posada, who is batting .165 in his first season as designated hitter, said in a televised interview. “It’s been a frustrating season so far.”
Girardi said he wasn’t surprised by the reception Posada, 39, received from Yankees fans when he came to bat last night.
“Jorge is loved in our clubhouse, loved by the fans and has meant a lot to the organization,” he said. “This has been a great player for a long time.”
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