Best and Worst Investments of 2012

By Ben Steverman - 2012-12-12T21:04:13Z

Photograph by Mark Harmel/Getty Images

Company Symbol % Change
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Best U.S. Large-Cap Stock

Regeneron Pharmaceuticals


Among the good news for Regeneron (REGN) shareholders were strong sales for a treatment for eye diseases. Total revenue jumped fourfold last quarter. The Tarrytown, N.Y.-based company also won approval for a chemotherapy drug and is developing drugs to treat rheumatoid arthritis and high cholesterol.

Universe and criteria: 358 stocks on U.S. exchanges with market capitalizations of more than $10 billion.