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Table: The Weapons Against AIDS


Companies are devising clever new approaches to keep HIV in check

1 For the virus to enter a cell, it must first attach to two receptors, or docking ports, on the cell. A drug delivered straight to such sites might thwart the virus before it docks. One type of drug in development seeks to block a receptor called CCR5. Another is aimed at the CD4 receptor.

2 If the virus attaches to the cell, it uncoils a harpoon-like device that plunges into the cell wall to force entry. So-called fusion inhibitor drugs keep the uncoiling from taking place.

3 After the virus gets in, it replicates by inserting its genes into the cell's chromosomes. This requires an enzyme called integrase. Drugs that disable integrase could prevent replication.


The Aging of Abercrombie & Fitch
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