Canada's benchmark S&P/TSX fell 48.57 points to 7,611.91.
Europe's markets closed mixed. London's FTSE 100 index was up 8.80 points, or 0.17%, to 5083 as the British Retail Consortium said retail confidence rose in March.
In Paris, the CAC-40 was down 4.72 points, or 0.11%, to 4,334.85 as French manufacturers' confidence rose in May.
Germany's DAX index was off 36.78 points, or 0.75% to 4,881.80 as German machine orders slump. However, published reports say German unemployment fell below 4 million in May.
Asia's markets closed lower.
The Nikkei index in Japan was down 83.03 points, or 0.70%, to 11,853.00 from poor sentiment following the poor finish on Wall Street Tuesday due to the lower-than-estimated May Consumer Confidence data. Exporter shares sent the market lower, and domestic-related shares were hurt by a less-than-expected increase in Japan's Industrial Production for April, which rose 0.2% month over month.
The Hang Seng index in Hong Kong was off 150.92 points, or 1.30%, to 11,430.66.