SHP: BARCLAYS PLC: Form 8.3 - Shire Plc

  SHP: BARCLAYS PLC: Form 8.3 - Shire Plc  UK Regulatory Announcement  LONDON                                     FORM 8.3             PUBLIC OPENING POSITION DISCLOSURE/DEALING DISCLOSURE BY      A PERSON WITH INTERESTS IN RELEVANT SECURITIES REPRESENTING 1% OR MORE                    Rule 8.3 of the Takeover Code (the “Code”)  1. KEY INFORMATION  (a) Identity of the person whose positions/dealings are being   Barclays PLC. disclosed: (b) Owner or controller of interests and short positions disclosed, if different from 1(a):                                The naming of nominee or vehicle companies is insufficient (c) Name of offeror/offeree in relation to whose relevant securities this form relates:                                   SHIRE PLC  Use a separate form for each offeror/offeree (d) If an exempt fund manager connected with an offeror/offeree, state this and specify identity of              offeror/offeree: (e) Date position held/dealing undertaken:                      22 July 2014                                                                  YES: (f) Has the discloser previously disclosed, or are they today disclosing, under the Code in respect of any other party to     ABBVIE INC this offer?                                                                    2. POSITIONS OF THE PERSON MAKING THE DISCLOSURE  (a) Interests and short positions in the relevant securities of the offeror or offeree to which the disclosure relates following the dealing (if any)  Class of relevant                            ORD                          security:                                        Interests          Short                                                                    Positions                                      Number      (%)     Number       (%) (1)               Relevant                   securities owned                   and/or controlled:   7,835,333   1.33%   2,501,046    0.42%                                                                     (2)               Derivatives (other                   than                   options):            549,054     0.09%   2,021,285    0.34%                                                                     (3)               Options and                   agreements to                   purchase/sell:       1,395,000   0.24%   1,514,400    0.26%                                                                     (4)               TOTAL:                                        9,779,387   1.66%   6,036,731    1.02%  All interests and all short positions should be disclosed.  Details of any open derivative or option positions, or agreements to purchase or sell relevant securities, should be given on a Supplemental Form 8 (Open Positions).  (b) Rights to subscribe for new securities (including directors’ and other executive options)  Class of relevant security in relation to which subscription right exists:   Details, including nature of the rights concerned and relevant percentages:   If there are positions or rights to subscribe to disclose in more than one class of relevant securities of the offeror or offeree named in 1(c), copy table 2(a) or (b) (as appropriate) for each additional class of relevant security.  3. DEALINGS (IF ANY) BY THE PERSON MAKING THE DISCLOSURE  (a) Purchases and sales  Class of relevant    Purchase/sale  Number of   Price per unit security                             securities    ORD                   Purchase        30           49.1440 GBP ORD                   Purchase        30           49.3230 GBP ORD                   Purchase        38           48.8400 GBP ORD (traded as ADR)   Purchase        39           254.4300 USD ORD                   Purchase        40           49.0740 GBP ORD                   Purchase        40           49.1050 GBP ORD                   Purchase        47           49.0840 GBP ORD                   Purchase        53           49.0790 GBP ORD                   Purchase        55           49.5547 GBP ORD                   Purchase        60           48.9540 GBP ORD                   Purchase        60           49.2050 GBP ORD                   Purchase        60           49.2190 GBP ORD                   Purchase        60           49.4100 GBP ORD                   Purchase        64           49.6340 GBP ORD                   Purchase        64           49.6980 GBP ORD                   Purchase        67           49.0140 GBP ORD                   Purchase        67           49.0390 GBP ORD                   Purchase        73           48.9000 GBP ORD                   Purchase        76           49.2750 GBP ORD                   Purchase        76           49.3350 GBP ORD                   Purchase        76           49.3740 GBP ORD                   Purchase        76           49.3890 GBP ORD                   Purchase        81           48.8650 GBP ORD                   Purchase        83           49.6250 GBP ORD                   Purchase        89           49.0440 GBP ORD                   Purchase        90           48.9900 GBP ORD                   Purchase        95           48.8800 GBP ORD (traded as ADR)   Purchase        96           254.2100 USD ORD                   Purchase        99           49.0850 GBP ORD                   Purchase        109          49.6150 GBP ORD                   Purchase        114          49.1950 GBP ORD                   Purchase        117          49.6850 GBP ORD                   Purchase        118          49.0250 GBP ORD                   Purchase        121          48.9800 GBP ORD                   Purchase        122          49.3250 GBP ORD                   Purchase        124          49.6550 GBP ORD                   Purchase        128          49.2700 GBP ORD                   Purchase        128          49.3450 GBP ORD                   Purchase        128          49.3640 GBP ORD                   Purchase        128          49.3690 GBP ORD                   Purchase        131          49.5540 GBP ORD                   Purchase        135          48.7350 GBP ORD                   Purchase        135          48.7600 GBP ORD                   Purchase        135          48.7840 GBP ORD                   Purchase        154          49.0931 GBP ORD                   Purchase        157          49.1800 GBP ORD                   Purchase        160          49.7200 GBP ORD                   Purchase        172          49.7350 GBP ORD                   Purchase        177          49.1100 GBP ORD                   Purchase        180          49.0760 GBP ORD                   Purchase        186          49.0150 GBP ORD                   Purchase        186          49.0450 GBP ORD                   Purchase        187          49.7050 GBP ORD                   Purchase        190          48.9890 GBP ORD                   Purchase        190          49.2010 GBP ORD                   Purchase        190          49.3650 GBP ORD                   Purchase        190          49.3750 GBP ORD                   Purchase        190          49.3900 GBP ORD                   Purchase        190          49.4950 GBP ORD                   Purchase        190          49.5440 GBP ORD                   Purchase        190          49.6040 GBP ORD                   Purchase        190          49.7400 GBP ORD                   Purchase        196          49.6450 GBP ORD                   Purchase        200          49.0268 GBP ORD                   Purchase        202          48.8850 GBP ORD                   Purchase        220          49.3050 GBP ORD                   Purchase        220          49.5040 GBP ORD                   Purchase        224          48.8550 GBP ORD                   Purchase        233          48.9350 GBP ORD                   Purchase        247          49.5100 GBP ORD                   Purchase        259          49.6050 GBP ORD                   Purchase        260          49.1900 GBP ORD                   Purchase        270          48.7250 GBP ORD                   Purchase        272          48.7900 GBP ORD                   Purchase        280          49.1700 GBP ORD                   Purchase        285          49.0550 GBP ORD                   Purchase        285          49.2100 GBP ORD                   Purchase        289          48.9300 GBP ORD                   Purchase        294          48.8100 GBP ORD                   Purchase        298          49.0350 GBP ORD                   Purchase        301          49.0050 GBP ORD                   Purchase        304          49.1750 GBP ORD                   Purchase        310          49.0650 GBP ORD                   Purchase        338          48.8000 GBP ORD                   Purchase        344          49.5950 GBP ORD                   Purchase        347          49.2080 GBP ORD                   Purchase        352          49.0750 GBP ORD                   Purchase        369          48.8700 GBP ORD                   Purchase        379          49.5450 GBP ORD                   Purchase        406          48.9100 GBP ORD                   Purchase        411          49.5850 GBP ORD                   Purchase        420          49.6950 GBP ORD                   Purchase        422          49.5000 GBP ORD                   Purchase        430          49.6750 GBP ORD                   Purchase        451          48.7800 GBP ORD                   Purchase        468          49.5250 GBP ORD                   Purchase        480          49.3400 GBP ORD                   Purchase        501          49.1350 GBP ORD                   Purchase        511          49.3800 GBP ORD                   Purchase        538          48.7700 GBP ORD                   Purchase        545          49.6350 GBP ORD                   Purchase        551          48.8900 GBP ORD                   Purchase        608          49.5200 GBP ORD                   Purchase        627          49.1300 GBP ORD                   Purchase        650          49.2200 GBP ORD                   Purchase        661          49.7500 GBP ORD                   Purchase        691          49.1400 GBP ORD                   Purchase        708          49.3500 GBP ORD                   Purchase        713          49.6214 GBP ORD                   Purchase        740          49.1200 GBP ORD                   Purchase        746          48.7000 GBP ORD                   Purchase        760          49.5350 GBP ORD                   Purchase        795          48.7200 GBP ORD                   Purchase        852          48.8200 GBP ORD (traded as ADR)   Purchase        900          253.6000 USD ORD (traded as ADR)   Purchase        900          253.8900 USD ORD                   Purchase        906          48.8300 GBP ORD                   Purchase        924          49.7300 GBP ORD                   Purchase        988          48.8600 GBP ORD                   Purchase        1,003        48.8500 GBP ORD                   Purchase        1,015        49.3200 GBP ORD                   Purchase        1,082        49.3100 GBP ORD                   Purchase        1,098        49.6600 GBP ORD                   Purchase        1,110        49.3700 GBP ORD                   Purchase        1,183        49.4900 GBP ORD                   Purchase        1,219        49.5593 GBP ORD                   Purchase        1,306        49.4600 GBP ORD                   Purchase        1,359        48.9600 GBP ORD                   Purchase        1,421        49.7100 GBP ORD                   Purchase        1,426        49.3300 GBP ORD                   Purchase        1,471        49.1000 GBP ORD (traded as ADR)   Purchase        1,500        254.2000 USD ORD                   Purchase        1,530        49.5500 GBP ORD                   Purchase        1,547        49.4342 GBP ORD                   Purchase        1,606        49.5300 GBP ORD                   Purchase        1,613        49.0100 GBP ORD                   Purchase        1,620        49.5900 GBP ORD                   Purchase        1,652        48.9550 GBP ORD                   Purchase        1,693        48.9650 GBP ORD                   Purchase        1,787        49.7000 GBP ORD                   Purchase        1,873        49.3600 GBP ORD                   Purchase        1,878        49.1064 GBP ORD                   Purchase        1,895        49.6500 GBP ORD                   Purchase        1,959        49.6800 GBP ORD                   Purchase        1,987        48.9450 GBP ORD                   Purchase        2,013        49.0700 GBP ORD                   Purchase        2,086        49.1500 GBP ORD (traded as ADR)   Purchase        2,100        254.1192 USD ORD                   Purchase        2,136        49.0300 GBP ORD                   Purchase        2,167        49.2998 GBP ORD                   Purchase        2,215        49.6400 GBP ORD                   Purchase        2,269        48.9500 GBP ORD                   Purchase        2,299        49.2169 GBP ORD                   Purchase        2,327        49.6299 GBP ORD                   Purchase        2,363        49.5400 GBP ORD                   Purchase        2,388        49.5700 GBP ORD                   Purchase        2,418        49.2687 GBP ORD                   Purchase        2,438        48.9400 GBP ORD                   Purchase        2,464        49.0800 GBP ORD (traded as ADR)   Purchase        2,487        253.6172 USD ORD                   Purchase        2,553        49.0900 GBP ORD                   Purchase        2,617        49.6200 GBP ORD                   Purchase        2,778        49.0400 GBP ORD                   Purchase        2,803        49.0200 GBP ORD                   Purchase        2,833        49.6100 GBP ORD                   Purchase        2,895        49.3000 GBP ORD                   Purchase        2,963        49.0000 GBP ORD                   Purchase        3,002        49.0500 GBP ORD (traded as ADR)   Purchase        3,300        253.2490 USD ORD                   Purchase        3,391        49.0600 GBP ORD                   Purchase        3,489        49.2000 GBP ORD                   Purchase        3,874        49.6000 GBP ORD                   Purchase        3,880        49.6300 GBP ORD (traded as ADR)   Purchase        3,882        253.7478 USD ORD                   Purchase        4,222        49.5650 GBP ORD                   Purchase        4,400        49.5329 GBP ORD                   Purchase        4,489        49.5600 GBP ORD (traded as ADR)   Purchase        5,400        252.6150 USD ORD (traded as ADR)   Purchase        5,400        254.1335 USD ORD (traded as ADR)   Purchase        5,700        254.0678 USD ORD                   Purchase        6,469        49.6700 GBP ORD                   Purchase        6,484        49.6900 GBP ORD                   Purchase        6,760        49.2603 GBP ORD                   Purchase        7,083        49.5550 GBP ORD                   Purchase        7,125        49.5800 GBP ORD (traded as ADR)   Purchase        9,975        253.5242 USD ORD (traded as ADR)   Purchase        10,818       254.3414 USD ORD (traded as ADR)   Purchase        13,800       253.8519 USD ORD (traded as ADR)   Purchase        14,100       253.9687 USD ORD                   Purchase        15,769       49.1659 GBP ORD                   Purchase        16,101       48.9950 GBP ORD                   Purchase        22,950       49.1826 GBP ORD                   Purchase        23,349       49.1040 GBP ORD (traded as ADR)   Purchase        23,514       254.2755 USD ORD                   Purchase        25,151       49.1515 GBP ORD (traded as ADR)   Purchase        25,500       253.9488 USD ORD (traded as ADR)   Purchase        33,717       253.1015 USD ORD                   Purchase        37,942       49.1273 GBP ORD (traded as ADR)   Purchase        38,199       254.2388 USD ORD (traded as ADR)   Purchase        40,500       254.3127 USD ORD                   Purchase        45,468       49.3466 GBP ORD (traded as ADR)   Purchase        49,650       253.4746 USD ORD                   Purchase        50,001       49.1458 GBP ORD                   Purchase        72,067       49.3702 GBP ORD (traded as ADR)   Purchase        72,558       254.0860 USD ORD (traded as ADR)   Purchase        75,000       254.3300 USD ORD (traded as ADR)   Purchase        88,386       254.1243 USD ORD                   Purchase        93,776       49.1248 GBP ORD                   Purchase        112,348      49.2291 GBP ORD                   Purchase        116,632      49.1365 GBP ORD (traded as ADR)   Purchase        133,200      254.1438 USD ORD (traded as ADR)   Purchase        147,129      254.3577 USD ORD (traded as ADR)   Purchase        180,000      253.8205 USD ORD (traded as ADR)   Purchase        233,559      254.1954 USD ORD                   Purchase        283,381      48.9213 GBP ORD (traded as ADR)   Purchase        285,000      254.1972 USD ORD                   Purchase        358,765      49.2512 GBP ORD (traded as ADR)   Purchase        591,000      254.3290 USD ORD (traded as ADR)   Purchase        591,000      254.3293 USD ORD                   Purchase        1,092,648    49.3808 GBP ORD                   Sale            30           49.1440 GBP ORD                   Sale            30           49.3230 GBP ORD                   Sale            38           48.8400 GBP ORD                   Sale            40           49.0740 GBP ORD                   Sale            40           49.1050 GBP ORD                   Sale            47           49.0840 GBP ORD                   Sale            50           49.2200 GBP ORD                   Sale            53           49.0790 GBP ORD                   Sale            60           48.9540 GBP ORD                   Sale            60           49.2050 GBP ORD                   Sale            60           49.2190 GBP ORD                   Sale            60           49.4100 GBP ORD                   Sale            64           49.6340 GBP ORD                   Sale            64           49.6980 GBP ORD                   Sale            67           49.0140 GBP ORD                   Sale            67           49.0390 GBP ORD                   Sale            67           49.1040 GBP ORD                   Sale            73           48.9000 GBP ORD                   Sale            76           49.2750 GBP ORD                   Sale            76           49.3350 GBP ORD                   Sale            76           49.3740 GBP ORD                   Sale            76           49.3890 GBP ORD                   Sale            81           48.8650 GBP ORD                   Sale            83           49.6250 GBP ORD                   Sale            84           49.5636 GBP ORD                   Sale            89           49.0440 GBP ORD                   Sale            90           48.9900 GBP ORD                   Sale            90           49.0719 GBP ORD                   Sale            95           48.8800 GBP ORD                   Sale            99           49.0850 GBP ORD                   Sale            101          48.9950 GBP ORD                   Sale            109          49.6150 GBP ORD                   Sale            114          49.1950 GBP ORD                   Sale            117          49.6850 GBP ORD                   Sale            118          49.0250 GBP ORD                   Sale            121          48.9800 GBP ORD                   Sale            122          49.3250 GBP ORD                   Sale            124          49.6550 GBP ORD                   Sale            125          49.5942 GBP ORD                   Sale            128          49.2700 GBP ORD                   Sale            128          49.3450 GBP ORD                   Sale            128          49.3640 GBP ORD                   Sale            128          49.3690 GBP ORD                   Sale            131          49.5540 GBP ORD                   Sale            135          48.7350 GBP ORD                   Sale            135          48.7600 GBP ORD                   Sale            135          48.7840 GBP ORD                   Sale            157          49.1800 GBP ORD                   Sale            160          49.7200 GBP ORD                   Sale            172          49.7350 GBP ORD                   Sale            177          49.1100 GBP ORD                   Sale            180          49.0760 GBP ORD                   Sale            186          49.0150 GBP ORD                   Sale            186          49.0450 GBP ORD                   Sale            187          49.7050 GBP ORD                   Sale            190          48.9890 GBP ORD                   Sale            190          49.2010 GBP ORD                   Sale            190          49.3650 GBP ORD                   Sale            190          49.3750 GBP ORD                   Sale            190          49.3900 GBP ORD                   Sale            190          49.4950 GBP ORD                   Sale            190          49.5440 GBP ORD                   Sale            190          49.6040 GBP ORD                   Sale            190          49.7400 GBP ORD                   Sale            196          49.6450 GBP ORD                   Sale            202          48.8850 GBP ORD                   Sale            220          49.3050 GBP ORD                   Sale            220          49.5040 GBP ORD                   Sale            224          48.8550 GBP ORD                   Sale            233          48.9350 GBP ORD                   Sale            247          49.5100 GBP ORD                   Sale            259          49.6050 GBP ORD                   Sale            260          49.1900 GBP ORD                   Sale            270          48.7250 GBP ORD                   Sale            272          48.7900 GBP ORD                   Sale            280          49.1700 GBP ORD                   Sale            285          49.0550 GBP ORD                   Sale            285          49.2100 GBP ORD                   Sale            289          48.9300 GBP ORD                   Sale            294          48.8100 GBP ORD                   Sale            298          49.0350 GBP ORD (traded as ADR)   Sale            300          253.9200 USD ORD (traded as ADR)   Sale            300          254.1400 USD ORD (traded as ADR)   Sale            300          254.1420 USD ORD (traded as ADR)   Sale            300          254.1500 USD ORD (traded as ADR)   Sale            300          254.4200 USD ORD (traded as ADR)   Sale            300          254.6200 USD ORD                   Sale            301          48.8900 GBP ORD                   Sale            301          49.0050 GBP ORD                   Sale            304          49.1750 GBP ORD                   Sale            310          49.0650 GBP ORD                   Sale            338          48.8000 GBP ORD                   Sale            344          49.5950 GBP ORD                   Sale            347          49.2080 GBP ORD                   Sale            352          49.0750 GBP ORD                   Sale            369          48.8700 GBP ORD                   Sale            379          49.5450 GBP ORD                   Sale            396          49.6825 GBP ORD                   Sale            406          48.9100 GBP ORD                   Sale            411          49.5850 GBP ORD                   Sale            420          49.6950 GBP ORD                   Sale            422          49.5000 GBP ORD                   Sale            430          49.6750 GBP ORD                   Sale            451          48.7800 GBP ORD                   Sale            468          49.5250 GBP ORD                   Sale            480          49.3400 GBP ORD                   Sale            501          49.1350 GBP ORD                   Sale            511          49.3800 GBP ORD (traded as ADR)   Sale            519          253.8139 USD ORD                   Sale            538          48.7700 GBP ORD                   Sale            545          49.6350 GBP ORD (traded as ADR)   Sale            600          254.0000 USD ORD (traded as ADR)   Sale            600          254.1540 USD ORD (traded as ADR)   Sale            600          254.1850 USD ORD                   Sale            608          49.5200 GBP ORD                   Sale            627          49.1300 GBP ORD                   Sale            661          49.7500 GBP ORD                   Sale            691          49.1400 GBP ORD                   Sale            708          49.3500 GBP ORD (traded as ADR)   Sale            717          253.8068 USD ORD                   Sale            740          49.1200 GBP ORD                   Sale            746          48.7000 GBP ORD                   Sale            760          49.5350 GBP ORD                   Sale            788          49.4643 GBP ORD                   Sale            795          48.7200 GBP ORD                   Sale            852          48.8200 GBP ORD (traded as ADR)   Sale            900          253.5000 USD ORD (traded as ADR)   Sale            900          254.3200 USD ORD                   Sale            906          48.8300 GBP ORD (traded as ADR)   Sale            915          254.1234 USD ORD                   Sale            924          49.7300 GBP ORD                   Sale            988          48.8600 GBP ORD                   Sale            1,003        48.8500 GBP ORD                   Sale            1,015        49.3200 GBP ORD                   Sale            1,082        49.3100 GBP ORD                   Sale            1,098        49.6600 GBP ORD                   Sale            1,110        49.3700 GBP ORD                   Sale            1,183        49.4900 GBP ORD (traded as ADR)   Sale            1,200        253.9711 USD ORD (traded as ADR)   Sale            1,200        253.9835 USD ORD (traded as ADR)   Sale            1,239        254.1517 USD ORD                   Sale            1,306        49.4600 GBP ORD                   Sale            1,359        48.9600 GBP ORD                   Sale            1,421        49.7100 GBP ORD                   Sale            1,426        49.3300 GBP ORD                   Sale            1,471        49.1000 GBP ORD                   Sale            1,526        48.9550 GBP ORD                   Sale            1,530        49.5500 GBP ORD                   Sale            1,570        49.0047 GBP ORD (traded as ADR)   Sale            1,596        253.8678 USD ORD                   Sale            1,606        49.5300 GBP ORD                   Sale            1,613        49.0100 GBP ORD                   Sale            1,620        49.5900 GBP ORD                   Sale            1,693        48.9650 GBP ORD                   Sale            1,782        49.3681 GBP ORD (traded as ADR)   Sale            1,800        253.8460 USD ORD                   Sale            1,873        49.3600 GBP ORD                   Sale            1,895        49.6500 GBP ORD                   Sale            1,959        49.6800 GBP ORD                   Sale            1,987        48.9450 GBP ORD                   Sale            2,070        49.1942 GBP ORD                   Sale            2,086        49.1500 GBP ORD                   Sale            2,136        49.0300 GBP ORD (traded as ADR)   Sale            2,202        254.4503 USD ORD                   Sale            2,215        49.6400 GBP ORD                   Sale            2,237        49.0700 GBP ORD                   Sale            2,269        48.9500 GBP ORD                   Sale            2,363        49.5400 GBP ORD                   Sale            2,388        49.5700 GBP ORD (traded as ADR)   Sale            2,400        252.9481 USD ORD                   Sale            2,438        48.9400 GBP ORD                   Sale            2,464        49.0800 GBP ORD                   Sale            2,563        49.0900 GBP ORD                   Sale            2,617        49.6200 GBP ORD (traded as ADR)   Sale            2,700        254.1335 USD ORD                   Sale            2,744        49.0923 GBP ORD                   Sale            2,778        49.0400 GBP ORD                   Sale            2,803        49.0200 GBP ORD                   Sale            2,825        49.5198 GBP ORD                   Sale            2,833        49.6100 GBP ORD                   Sale            2,895        49.3000 GBP ORD                   Sale            2,943        49.2554 GBP ORD                   Sale            2,963        49.0000 GBP ORD                   Sale            2,988        49.1204 GBP ORD                   Sale            3,002        49.0500 GBP ORD                   Sale            3,153        49.2244 GBP ORD                   Sale            3,279        49.0479 GBP ORD                   Sale            3,345        49.7000 GBP ORD                   Sale            3,391        49.0600 GBP ORD                   Sale            3,487        49.5732 GBP ORD                   Sale            3,489        49.2000 GBP ORD                   Sale            3,579        49.1381 GBP ORD (traded as ADR)   Sale            3,600        253.8100 USD ORD                   Sale            3,651        49.5615 GBP ORD                   Sale            3,874        49.6000 GBP ORD                   Sale            3,880        49.6300 GBP ORD                   Sale            3,900        49.3667 GBP ORD                   Sale            4,222        49.5650 GBP ORD                   Sale            4,489        49.5600 GBP ORD (traded as ADR)   Sale            4,500        254.0043 USD ORD (traded as ADR)   Sale            5,700        254.0678 USD ORD (traded as ADR)   Sale            6,000        254.0545 USD ORD                   Sale            6,469        49.6700 GBP ORD                   Sale            6,484        49.6900 GBP ORD                   Sale            7,083        49.5550 GBP ORD                   Sale            7,125        49.5800 GBP ORD                   Sale            7,300        49.0429 GBP ORD (traded as ADR)   Sale            8,700        253.9265 USD ORD (traded as ADR)   Sale            8,964        253.9634 USD ORD (traded as ADR)   Sale            9,087        253.6863 USD ORD (traded as ADR)   Sale            9,366        253.9599 USD ORD (traded as ADR)   Sale            10,764       254.0390 USD ORD (traded as ADR)   Sale            11,700       254.1331 USD ORD                   Sale            12,333       49.3359 GBP ORD                   Sale            14,096       49.3197 GBP ORD (traded as ADR)   Sale            14,100       253.9687 USD ORD (traded as ADR)   Sale            19,500       253.9841 USD ORD (traded as ADR)   Sale            19,731       254.0586 USD ORD                   Sale            20,000       49.5412 GBP ORD                   Sale            25,000       49.0245 GBP ORD                   Sale            28,645       48.9249 GBP ORD                   Sale            28,836       49.3730 GBP ORD                   Sale            29,000       49.6650 GBP ORD                   Sale            29,504       49.5532 GBP ORD                   Sale            32,213       49.3438 GBP ORD                   Sale            32,774       49.3107 GBP ORD                   Sale            35,000       49.1534 GBP ORD                   Sale            41,435       49.1777 GBP ORD                   Sale            49,008       49.3895 GBP ORD (traded as ADR)   Sale            64,938       254.0184 USD ORD                   Sale            69,165       49.3677 GBP ORD (traded as ADR)   Sale            75,000       254.3300 USD ORD                   Sale            85,751       49.1197 GBP ORD (traded as ADR)   Sale            92,349       253.3470 USD ORD                   Sale            95,966       49.1239 GBP ORD                   Sale            123,457      49.4706 GBP ORD (traded as ADR)   Sale            180,000      253.8205 USD ORD                   Sale            184,335      49.2730 GBP ORD (traded as ADR)   Sale            198,300      254.1508 USD ORD                   Sale            217,295      49.2691 GBP ORD                   Sale            242,935      49.2212 GBP ORD                   Sale            306,010      49.2365 GBP ORD (traded as ADR)   Sale            776,400      254.1991 USD ORD                   Sale            787,249      49.4065 GBP ORD (traded as ADR)   Sale            1,182,000    254.3293 USD  (b) Derivatives transactions (other than options)  Class of  Product      Nature of dealing  Number of   Price per relevant   description                       reference    unit security                                   securities    ORD        CFD           Long                942          49.6086 GBP ORD        SWAP          Long                1,570        49.0046 GBP ORD        CFD           Long                1,700        49.5455 GBP ORD        CFD           Long                859          48.8733 GBP ORD        CFD           Long                1,782        49.3681 GBP ORD        SWAP          Long                1,900        49.5500 GBP ORD        CFD           Long                2,001        49.0891 GBP ORD        SWAP          Long                2,356        49.1954 GBP ORD        CFD           Long                2,988        49.1204 GBP ORD        CFD           Long                3,579        49.1381 GBP ORD        CFD           Long                3,900        49.3667 GBP ORD        CFD           Long                5,497        49.4915 GBP ORD        SWAP          Long                6,816        49.1859 GBP ORD        SWAP          Short               55           49.5547 GBP ORD        SWAP          Short               113          49.6084 GBP ORD        CFD           Short               1,200        49.5544 GBP ORD        SWAP          Short               1,900        49.5500 GBP ORD        CFD           Short               6,373        49.1432 GBP ORD        SWAP          Short               6,815        49.1771 GBP ORD        CFD           Short               6,760        49.2603 GBP ORD        SWAP          Short               46,148       49.2459 GBP ORD        CFD           Short               37,342       49.3862 GBP  (c) Options transactions in respect of existing securities  (i) Writing, selling, purchasing or varying  Class     Product      Writing,     Number      Exercise  Type      Expiry  Option of         description   purchasing,   of           price                 date     money relevant                 selling,      securities   per unit                       paid/ security                 varying etc   to which                                    received                                        option                                      per unit                                     relates                                   ADR        Call          Purchasing    20,000       255 USD    American   16 Aug   4.0000            Options                                                        2014     USD ADR        Put Options   Purchasing    500          240 USD    American   18 Oct   4.6280                                                                           2014     USD ADR        Put Options   Selling       500          230 USD    American   18 Oct   3.3480                                                                           2014     USD  (ii) Exercising                       Product Class of relevant   description         Number of          Exercise price security                                  securities          per unit                      e.g. call option  (d) Other dealings (including subscribing for new securities)                      Nature of dealing Class of relevant                      Details  Price per unit (if security            e.g. subscription,             applicable)                     conversion  The currency of all prices and other monetary amounts should be stated.  Where there have been dealings in more than one class of relevant securities of the offeror or offeree named in 1(c), copy table 3(a), (b), (c) or (d) (as appropriate) for each additional class of relevant security dealt in.  4. OTHER INFORMATION  (a) Indemnity and other dealing arrangements  Details of any indemnity or option arrangement, or any agreement or understanding, formal or informal, relating to relevant securities which may be an inducement to deal or refrain from dealing entered into by the person making the disclosure and any party to the offer or any person acting in concert with a party to the offer:  If there are no such agreements, arrangements or understandings, state “none” NONE  (b) Agreements, arrangements or understandings relating to options or derivatives  Details of any agreement, arrangement or understanding, formal or informal, between the person making the disclosure and any other person relating to:  (i) the voting rights of any relevant securities under any option; or  (ii) the voting rights or future acquisition or disposal of any relevant securities to which any derivative is referenced:  If there are no such agreements, arrangements or understandings, state “none” NONE  (c) Attachments  Is a Supplemental Form 8 (Open Positions) attached?  YES  Date of disclosure:  23 Jul 2014 Contact name:         Rajesh Muthanna Telephone number:     020 3555 4634  Public disclosures under Rule 8 of the Code must be made to a Regulatory Information Service and must also be emailed to the Takeover Panel at monitoring@disclosure.org.uk. The Panel’s Market Surveillance Unit is available for consultation in relation to the Code’s dealing disclosure requirements on +44 (0)20 7638 0129.  The Code can be viewed on the Panel’s website at www.thetakeoverpanel.org.uk.  143221.01                       SUPPLEMENTAL FORM 8 (OPEN POSITIONS)    DETAILS OF OPEN OPTION AND DERIVATIVE POSITIONS, AGREEMENTS TO PURCHASE OR                                   SELL ETC.              Note 5(i) on Rule 8 of the Takeover Code (the “Code”)  1. KEY INFORMATION  Identity of person whose open positions are being disclosed:   Barclays PLC. Name of offeror/offeree in relation to whose relevant           SHIRE PLC securities the disclosure relates:  2. OPTIONS AND DERIVATIVES  Class     Product      Writing,     Number      Exercise  Type      Expiry of         description   purchasing,   of           price                 date relevant                 selling,      securities   per unit security                 varying etc   to which                                        option                                     relates                           ADR        Put Options   Purchased     -300         160.0000   American   18 Oct                                                                           2014 ADR        Put Options   Purchased     -2,800       160.0000   American   17 Jan                                                                           2015 ADR        Put Options   Purchased     -600         185.0000   American   17 Jan                                                                           2015 ADR        Put Options   Purchased     -200         190.0000   American   18 Oct                                                                           2014 ADR        Put Options   Purchased     -100         215.0000   American   16 Aug                                                                           2014 ADR        Put Options   Purchased     -100         220.0000   American   16 Aug                                                                           2014 ADR        Put Options   Purchased     -300         230.0000   American   18 Oct                                                                           2014 ADR        Put Options   Purchased     -1,100       240.0000   American   16 Aug                                                                           2014 ADR        Put Options   Purchased     -1,600       240.0000   American   18 Oct                                                                           2014 ADR        Put Options   Purchased     -3,800       250.0000   American   16 Aug                                                                           2014 ADR        Put Options   Purchased     -300         255.0000   American   17 Jan                                                                           2015 ADR        Put Options   Purchased     -1,000       260.0000   American   18 Oct                                                                           2014 ADR        Put Options   Purchased     -1,600       270.0000   American   16 Aug                                                                           2014 ADR        Put Options   Written       100          140.0000   American   18 Oct                                                                           2014 ADR        Put Options   Written       300          145.0000   American   18 Oct                                                                           2014 ADR        Put Options   Written       300          150.0000   American   18 Oct                                                                           2014 ADR        Put Options   Written       1,100        165.0000   American   18 Oct                                                                           2014 ADR        Put Options   Written       500          170.0000   American   18 Oct                                                                           2014 ADR        Put Options   Written       300          180.0000   American   18 Oct                                                                           2014 ADR        Put Options   Written       700          195.0000   American   18 Oct                                                                           2014 ADR        Put Options   Written       100          200.0000   American   16 Aug                                                                           2014 ADR        Put Options   Written       200          200.0000   American   18 Oct                                                                           2014 ADR        Put Options   Written       300          205.0000   American   18 Oct                                                                           2014 ADR        Put Options   Written       100          210.0000   American   16 Aug                                                                           2014 ADR        Put Options   Written       200          220.0000   American   17 Jan                                                                           2015 ADR        Put Options   Written       100          225.0000   American   16 Aug                                                                           2014 ADR        Put Options   Written       200          230.0000   American   17 Jan                                                                           2015 ADR        Put Options   Written       100          235.0000   American   18 Oct                                                                           2014 ADR        Put Options   Written       300          275.0000   American   18 Oct                                                                           2014 ADR        Put Options   Written       300          280.0000   American   18 Oct                                                                           2014 ADR        Call          Purchased     1,800        165.0000   American   18 Oct            Options                                                        2014 ADR        Call          Purchased     1,600        215.0000   American   16 Aug            Options                                                        2014 ADR        Call          Purchased     1,000        215.0000   American   18 Oct            Options                                                        2014 ADR        Call          Purchased     900          230.0000   American   16 Aug            Options                                                        2014 ADR        Call          Purchased     100          240.0000   American   16 Aug            Options                                                        2014 ADR        Call          Purchased     1,600        250.0000   American   17 Jan            Options                                                        2015 ADR        Call          Purchased     20,000       255.0000   American   16 Aug            Options                                                        2014 ADR        Call          Purchased     200          255.0000   American   18 Oct            Options                                                        2014 ADR        Call          Purchased     123,900      260.0000   American   16 Aug            Options                                                        2014 ADR        Call          Purchased     3,500        260.0000   American   18 Oct            Options                                                        2014 ADR        Call          Purchased     400          260.0000   American   17 Jan            Options                                                        2015 ADR        Call          Purchased     1,600        265.0000   American   16 Aug            Options                                                        2014 ADR        Call          Purchased     3,100        265.0000   American   18 Oct            Options                                                        2014 ADR        Call          Purchased     300,000      270.0000   American   17 Jan            Options                                                        2015 ADR        Call          Purchased     100          280.0000   American   16 Aug            Options                                                        2014 ADR        Call          Written       -1,200       155.0000   American   18 Oct            Options                                                        2014 ADR        Call          Written       -2,500       160.0000   American   18 Oct            Options                                                        2014 ADR        Call          Written       -5,800       175.0000   American   18 Oct            Options                                                        2014 ADR        Call          Written       -200         180.0000   American   18 Oct            Options                                                        2014 ADR        Call          Written       -100         180.0000   American   17 Jan            Options                                                        2015 ADR        Call          Written       -1,100       190.0000   American   18 Oct            Options                                                        2014 ADR        Call          Written       -2,300       195.0000   American   18 Oct            Options                                                        2014 ADR        Call          Written       -2,000       200.0000   American   18 Oct            Options                                                        2014 ADR        Call          Written       -200         210.0000   American   18 Oct            Options                                                        2014 ADR        Call          Written       -2,200       220.0000   American   18 Oct            Options                                                        2014 ADR        Call          Written       -1,600       230.0000   American   18 Oct            Options                                                        2014 ADR        Call          Written       -500         230.0000   American   17 Jan            Options                                                        2015 ADR        Call          Written       -1,000       235.0000   American   18 Oct            Options                                                        2014 ADR        Call          Written       -142,000     240.0000   American   16 Aug            Options                                                        2014 ADR        Call          Written       -100         240.0000   American   18 Oct            Options                                                        2014 ADR        Call          Written       -200         240.0000   American   17 Jan            Options                                                        2015 ADR        Call          Written       -600         245.0000   American   17 Jan            Options                                                        2015 ADR        Call          Written       -18,100      250.0000   American   16 Aug            Options                                                        2014 ADR        Call          Written       -100         255.0000   American   16 Aug            Options                                                        2014 ADR        Call          Written       -300,000     255.0000   American   17 Jan            Options                                                        2015 ADR        Call          Written       -6,000       265.0000   American   16 Aug            Options                                                        2014 ADR        Call          Written       -1,000       265.0000   American   17 Jan            Options                                                        2015 ADR        Call          Written       -200         270.0000   American   18 Oct            Options                                                        2014 ADR        Call          Written       -1,900       270.0000   American   17 Jan            Options                                                        2015 ADR        Call          Written       -100         320.0000   American   17 Jan            Options                                                        2015  3. AGREEMENTS TO PURCHASE OR SELL ETC.  Full details should be given so that the nature of the interest or position can be fully understood:  It is not necessary to provide details on a Supplemental Form (Open Positions) with regard to contracts for differences (“CFDs”) or spread bets.  The currency of all prices and other monetary amounts should be stated.  The Panel’s Market Surveillance Unit is available for consultation in relation to the Code’s dealing disclosure requirements on +44 (0)20 7638 0129.  The Code can be viewed on the Panel’s website at www.thetakeoverpanel.org.uk.  Contact:  BARCLAYS PLC  
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