In China, Surveyed Nephrologists Report Significant Declines in the Use of ESAs in Stage 3, 4 and 5 Chronic Kidney Disease Non-

  In China, Surveyed Nephrologists Report Significant Declines in the Use of      ESAs in Stage 3, 4 and 5 Chronic Kidney Disease Non-Dialysis Patient                        Populations, Compared with 2011  After Review of Three Renal Anemia Product Profiles in Development, Expected Use Increases with Disease Severity, According to Findings from Decision Resources Group  PR Newswire  BURLINGTON, Mass., July 1, 2014  BURLINGTON, Mass., July 1, 2014 /PRNewswire/ --Decision Resources Group finds that patient chart data submitted by surveyed nephrologists in China reveals that, consistent with 2011, the percentage of patients on erythropoiesis-stimulating agents (ESAs) significantly increases as chronic kidney disease (CKD) worsens; however, for stage 3, stage 4 and stage 5 non-dialysis (ND), the percentage of patients on ESAs has declined significantly compared with 2011.   Decision Resources Group Logo.  Other key findings from the report entitled ChartTrends: Renal Anemia in CKD-ND (China) 2014:    oESA-treated patient demographics: Patients treated with ESAs tend to be in     a later stage of CKD; tend to have more comorbidities and lower hemoglobin     levels; are more likely to be on traditional Chinese medicine for the     treatment of renal anemia; are more likely to be on iron (IV or oral),     phosphate binders, and active Vitamin D; and are of higher economic status     compared with ESA non-treated patients. (The report also includes patient     share data for Shenyang Sunshine Pharmaceutical's Yi Bi Ao, Kyowa Hakko     Kirin's ESPO, Hua Bae Pharm's Ji Main Xin and other agents.)   oOver-reporting of IV iron use in Stage 3: While surveyed nephrologists'     report that the percentage of CKD stage 4 patients on IV iron is     consistent with chart audited data, respondents appear to overestimate the     percentage of stage 3 patients who are treated with IV iron. (The report     also includes further details on IV iron patient share, discontinuation     rates, transferrin saturation and ferritin distributions at last measure     and at IV iron initiation, IV iron administration location, dosing,     switching and rationale for switching from oral to IV iron, among other     topics.)   oExpected use of products in development: New to this study, nephrologists     reviewed product profiles of three products in late-stage development for     renal anemia. Then, nephrologists indicated whether a particular patient     would or would not be eligible for treatment with these products and why     or why not they would be eligible for treatment with these products. Among     those that would be eligible, nephrologists were asked whether a patient's     current ESA use would change. Products covered in the report include     FibroGen's/AstraZeneca's/Astellas's roxadustat, Akebia's AKB-6548 and     Keryx/Japan Tobacco's Zerenex/Riona. Not surprisingly, expected use     increases with stage of the disease.  Comments from Decision Resources Group Director Rob Dubman:    o"It is not surprising that information from patient charts show declines     in the use of ESAs because we have generally observed this trend in other     markets around the globe as well."   o"Adding product profiles to this study created some interesting findings.     For example, this physician exercise allows manufactures to see how     expected use differs by lab values and/or other patient demographics."  About Decision Resources Group  Decision Resources Group offers best-in-class, high-value information and insights on critical issues within the healthcare industry. Clients rely on this analysis and data to make informed decisions. Find out more at www.DecisionResourcesGroup.com.  All company, brand, or product names contained in this document may be trademarks or registered trademarks of their respective holders.  For more information, contact:  Decision Resources Group Christopher Comfort 781-993-2597 ccomfort@dresourcesgroup.com  Logo- http://photos.prnewswire.com/prnh/20130103/MM36768LOGO  SOURCE Decision Resources Group  Website: http://www.decisionresourcesgroup.com  
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