Milestone Study Shows Oral Supplement Setria® Glutathione Effectively Enhances Body's Most Important Protective Antioxidant

Milestone Study Shows Oral Supplement Setria® Glutathione Effectively Enhances
                 Body's Most Important Protective Antioxidant

Long-Term Human Clinical Trial Data Now Available

PR Newswire

NEW YORK, June 4, 2014

NEW YORK, June 4, 2014 /PRNewswire/ --A new long-term, randomized,
double-blinded, placebo-controlled human clinical trial, published in the May
issue of the European Journal of Nutrition, revealed for the first time that
daily consumption of a Setria^® Glutathione supplement was effective at
increasing body stores of glutathione – an antioxidant generated within our
bodies to help fight disease – combating long-held contrary beliefs.^1
Glutathione is a tripeptide that is naturally found in nearly all cells,
tissues and organ systems in the body. It is also known as the "master
antioxidant" due to its vast functions of antioxidant protection,
detoxification and immune system fortification. But, for many reasons
including age, prescription and OTC medication intake, health conditions,
lifestyle, diet, weight and even time of day, the body's stores of glutathione
may be in short supply. This six-month clinical trial – led by Dr. John P.
Richie of Penn State University – evaluated the efficacy of Setria^®
Glutathione supplementation at enhancing body stores of glutathione, and the
results show that glutathione supplementation may represent an effective
intervention strategy to not only enhance body stores but also boost the
body's immune function. ^1

Dr. Richie has studied glutathione for more than 25 years, and his body of
research focuses primarily on fighting oxidative stress, which is a
contributing factor to most fatal diseases. "It is well-known in the science
community that glutathione is one of the primary protective molecules in the
body; however, whether or not glutathione levels could be supplemented by oral
glutathione administration has been hotly debated and clinical data has been
lacking" said Dr. John P. Richie, Jr., Ph.D., Professor of Public Health
Sciences and Pharmacology at Penn State University School of Medicine. "Now we
have evidence to illustrate the potential benefit of glutathione
supplementation on improved immune health, potentially decreased risk of
cancer, and reduction of other diseases related to oxidative stress."

"Kyowa Hakko pioneered a fermentation technology that is used to manufacture
amino acids, nucleic acids, vitamins and related compounds to dietary
supplements," said Danielle Citrolo, PharmD, technical services manager at
Kyowa Hakko USA, Inc. "We couldn't be more pleased about the publication of
this study and its potential to help our customers. Even the healthiest
individuals face environmental factors and toxins that can combat the positive
effects of a well-rounded diet, and thus could benefit from an antioxidant
supplementation, like Setria^® Glutathione."

About the Study:

  oTrial measured effect of glutathione supplementation at 250 mg/day and
    1000 mg/day on glutathione levels in different blood components and
    exfoliated buccal mucosal cells over a six month period.^1
  oSubjects were 54 healthy adults (41 females/13 males), 28-72 years of age
    (mean=46.6 years).^1
  oResults of the study showed glutathione levels in the blood increased
    after one, three and six months vs. baseline at both doses.^1
  oAt six months, mean glutathione levels increased 30-35 percent in
    erythrocytes, plasma, and lymphocytes, and 260 percent in buccal cells in
    the high dose group (P<0.05). ^ 1
  oGlutathione levels increased 17 and 29 percent in blood and erythrocytes,
    respectively, in the low dose group (P<0.05).^1
  oNatural killer cytotoxicity increased two fold in the high-dose group
    versus placebo at 3 months. ^ 1
  oA reduction in oxidative stress in both glutathione dose groups was
    indicated by decreases in the oxidized to reduced glutathione ratio in
    whole blood after 6 months.^1
  oAccording to the study, the effects of glutathione supplementation on the
    levels of the glutathione precursor cysteine in plasma and the activity of
    the rate-limiting glutathione biosynthetic enzyme GCL in erythrocytes were
    examined after the six-month study period.^1 No changes were observed in
    cyst(e)ine concentrations or GCL activity in any of the groups.^1

This study was supported by Kyowa Hakko USA, Inc. and Kyowa Hakko Bio. Ltd.
Setria^® Glutathione can be found in select supplement manufacturers. For more
information visit

About Setria® Glutathione:
Setria^® Glutathione, manufactured by Kyowa Hakko Bio Co., Ltd., is a
clinically studied form of glutathione that, when taken orally, has been shown
to replenish the body's reserves, which may be depleted as a result of poor
lifestyle choices, stress or natural aging. Called the "master antioxidant,"
glutathione helps protect cells in the body from the damaging effects of
oxidative stress and toxins. Setria Glutathione is manufactured through a
patented fermentation and patent pending for increasing natural killer (NK)
cell activity, is pure, vegetarian and allergen-free. For more information
about Setria Glutathione, visit

About Kyowa Hakko USA:
Kyowa Hakko USA is the North American sales office for Kyowa Hakko Bio Co.
Ltd., an international health ingredients manufacturer and world leader in the
development, manufacturing and marketing of pharmaceuticals, nutraceuticals
and food products. Kyowa is the maker of branded ingredients including
Cognizin^® Citicoline, Pantesin^® Pantethine, Setria^® Glutathione, as well as
Sustamine^® L-Alanyl-L-Glutamine. For more information, visit

^1 Richie JP Jr, Nichenametla S, Neidig W, Calcagnotto A, Haley JS, Schell TD,
Muscat JE. Randomized controlled trial of oral glutathione supplementation on
body stores of glutathione. Eur J Nutr. 2014 May 5. [Epub ahead of print]
PubMed PMID: 24791752.

Media Contact:
Kristen Ingraham
(212) 601 8238

SOURCE Kyowa Hakko USA

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