Summit participants suggest pathway to greater adoption of Negative Pressure Wound Therapy

 Summit participants suggest pathway to greater adoption of Negative Pressure
                                Wound Therapy

PR Newswire

ST. PETERSBURG, Fla., May 19, 2014

ST. PETERSBURG, Fla., May 19, 2014 /PRNewswire/ -- Smith & Nephew (LSE:SN,
NYSE:SNN), the global medical technology business, reports a survey of
participants at its first North American Negative Pressure Wound Therapy
Summit outlining a pathway to greater adoption of Negative Pressure Wound
Therapy (NPWT).

The Summit, titled "Unlocking the Potential of NPWT," provided a forum for
discussion of new clinical research and issues relevant to helping patients
suffering with traumatic, chronic and post-surgical wounds. The survey
revealed consensus that NPWT has a key role to play in reducing the cost of
wound care and improving patient outcomes, and identified areas where progress
and innovation could drive adoption of NPWT across a broader range of wounds.

The Summit's 115 participants came from across the clinical spectrum that
treats the full range of wound types. The largest numbers of participants
were from wound care, plastic, general and orthopaedic surgery, OB/GYN and
podiatry. Participants came from twenty-five states in the US as well as
Canada. The survey included responses from 92 participants, and revealed the
following:

  o91% are actively seeking to implement innovative wound treatments that
    will lower costs and improve patient outcomes.
  o89% believe that up to 75% of all wounds they treat could be treated more
    effectively with NPWT.
  o82% agree that improved healing is NPWT's greatest benefit to patient
    care; 11% said that the greatest benefit was shortened length of stay.
    (The survey technology allowed for only one response per question.)
  o81% said that NPWT has the potential to reduce the overall cost of wound
    care.
  oAnd 76% agree that it is important for NPWT to expand beyond its current
    use. Of the broad areas in which NPWT is most commonly used, 22% believe
    that general surgery includes the most promising, potential new uses for
    NPWT; 19% said plastics, 19% podiatry and 16% orthopaedics.

Along with this interest in expanding NPWT within general surgery,
participants are keen to see NPWT's application to closed surgical incisions,
especially for the potential of improvement in the control of surgical site
infection (SSI). Survey responses indicate that this is a compelling
opportunity for growth:

  o66% of participants agree that more widespread use of NPWT may have a
    significant impact on the rate of SSI.
  o95% are using NPWT on less than half of closed incisions at this time.

When asked which single factor could expand access to NPWT in their
facilities, 39% of participants indicated that reduced cost would help the
most, followed by ease of implementation of treatment (26%) and easier access
to the technology (22%). The top three factors that would increase the
individual clinician's use of NPWT were improved patient access to NPWT (39%),
reduced cost (32%) and increased clinical indications (11%).

"It was wonderful to have experts from so many specialities across the
spectrum together at the Summit," said Michael Sugrue, MD, Chair of the Summit
and Surgeon at Letterkenny Hospital and Galway University, Ireland. "Medicine
is best delivered by a team. The patient requires it. Opportunities like the
NPWT Summit bring us together as a team, sharing best practices and new
research.

"There is little if any doubt that NPWT is a critically important tool for the
treatment of chronic and traumatic wounds, and the emerging focus on surgical
incisions is beginning to fill a pressing need to reduce post-surgical
infection," Dr. Sugrue added. "Very clearly, clinicians are looking for more
to be done to make the therapy more accessible, easier for the clinician to
manage and easier to deliver at home or in the community. These are exciting
opportunities for innovation to extend the benefits of NPWT over a broader
range of patients with all manner of wounds."

Video interviews featuring several Summit participants and an article on the
event's proceedings are available here, at www.myrenasys.com.

Presentations from Summit faculty aligned recent evidence on the efficacy of
NPWT for the treatment of open wounds with the current emphasis on cost
efficiency and improved outcomes driven by the Affordable Care Act, and for
the treatment of post-surgical incisions with the American College of
Surgeons' National Surgical Quality Improvement Program. For example, the
program included:

  oDr. John C. Lantis, Chief of the Vascular/Endovascular Surgery Division at
    St Luke's-Roosevelt Hospital in New York and Associate Professor of
    Clinical Surgery at Columbia University, who discussed the role of
    adjunctive therapies alongside NPWT to maximize wound bed preparation in
    open wounds. Although some of the evidence is still emerging, Dr. Lantis
    shared his experiences using NPWT adjunctive therapies in order to close
    wounds as quickly as possible, including debridement, irrigation and
    topical therapies depending on the desired treatment objectives for each
    particular patient.
  oDr. Sudheer Karlakki, Consultant Orthopaedic and Arthroplasty Surgeon at
    Robert Jones & Agnes Hunt Hospital, Oswestry in the UK, reviewed the
    accumulating evidence for the use of NPWT in closed incisions before
    presenting top-line results from two studies soon to be published from his
    own group. In the first study, on 120 hip and knee revisions, standard
    dressings or NPWT were applied in the operating room to two groups after
    surgery. They noted a large reduction in length of stay for patients with
    wound related complications. In the second study (a 220 patient RCT)
    treating hip and knee primary arthroplasties with PICO* Negative Pressure
    Wound Therapy or standard dressings, they were able to discharge patients
    with leaky wounds one day earlier with the PICO system. He concluded that
    NPWT helps to achieve predictable wound healing, minimize wound
    complications and reduce length of stay.
  oDr. Craig Olson, Assistant Professor – Section of Colon and Rectal
    Surgery, Division of GI Surgery, University of Texas Southwestern Medical
    Center in Dallas presented his recently published work demonstrating that
    incisional NPWT can significantly reduce SSI following colorectal surgery.
    Colorectal operations are commonly associated with higher rates of SSI
    (5-45%) leading to increased patient morbidity, cost of care and length of
    stay. Dr. Olson described findings from a retrospective review of 254
    patients in their center, which revealed that while the presence of
    diabetes was associated with a greater risk of SSI in colorectal surgery,
    the use of incisional NPWT actually decreased the likelihood of SSI by
    more than half.

Additional presentations focused on the NPWT mode of action in different wound
types, reviewing the evidence for incisional NPWT, the impact of biofilms on
wound healing and the emerging consensus guidelines for NPWT. Breakout
sessions discussed surgical site complication management strategies, and
experiences with the use of NPWT in plastic and abdominal surgery.

The North American NPWT Summit convened in Dallas, Texas, on May 2 and 3. The
Summit and associated educational activities were supported by Smith &
Nephew.

The survey was conducted with an audience response system that utilized a
wireless keypad technology allowing for immediate response polling,
participants were asked to select the single best response to each question.

1.Karlakki S, Brem M, Giannini S, Khanduja V, Stannard J, Martin R. Negative
    pressure wound therapy for management of the surgical incision in
    orthopaedic surgery: A review of evidence and mechanisms for an emerging
    indication. Bone Joint Res. 2013;2(12):276–84.
    doi:10.1302/2046-3758.212.2000190.
2.Bonds AM, Novick TK, Dietert JB, Araghizadeh FY, Olson CH. Incisional
    negative pressure wound therapy significantly reduces surgical site
    infection in open colorectal surgery. Dis Colon Rectum.
    2013;56(12):1403–1408. doi:10.1097/DCR.0b013e3182a39959.

About Smith & Nephew

Smith & Nephew is a global medical technology business dedicated to helping
healthcare professionals improve people's lives. With leadership positions in
Orthopaedic Reconstruction, Advanced Wound Management, Sports Medicine and
Trauma & Extremities, Smith & Nephew has around 11,000 employees and a
presence in more than 90 countries. Annual sales in 2013 were more than $4.3
billion. Smith & Nephew is a member of the FTSE100 (LSE: SN, NYSE: SNN).

For more information about Smith & Nephew, please visit our corporate website
www.smith-nephew.com, follow @SmithNephewplc on Twitter or visit
SmithNephewplc on Facebook.com

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