Apricus Biosciences Provides Corporate Update and First Quarter 2014 Financial Results

Apricus Biosciences Provides Corporate Update and First Quarter 2014 Financial
Results

       Takeda Begins Sampling Effort of Vitaros^® in the United Kingdom

  FDA Clears RayVa^™ Investigational New Drug Application to Begin Clinical
                Studies in Patients with Raynaud's Phenomenon

   Conference Call and Webcast Today, Monday, May 12, 2014 at 5:00 p.m. ET

SAN DIEGO, May 12, 2014 (GLOBE NEWSWIRE) -- Apricus Biosciences, Inc. (Nasdaq:
APRI), a pharmaceutical company focusing on the development and
commercialization of novel therapeutics for men's and women's health, today
provided a corporate update and reported financial results for the first
quarter 2014.

"Since the beginning of 2014, we have made significant progress towards
achieving our annual corporate goals, which included launching Vitaros^® and
building a diversified pipeline of novel therapeutics," stated Richard W.
Pascoe, Chief Executive Officer. "In April 2014, we completed the first
shipment of Vitaros to Takeda for product launch in the United Kingdom.
Earlier today, Takeda launched a comprehensive Vitaros sampling program
throughout their territory directed towards key opinion leaders of erectile
dysfunction treatments. We are delighted that Takeda has taken this important
step towards making Vitaros available to physicians and patients in advance of
the expected commercial launch of Vitaros in the United Kingdom in June. We
applaud Takeda's disciplined and thorough approach to being the first Vitaros
partner to introduce the only topical, on-demand treatment for erectile
dysfunction, and we are confident that their efforts will set the stage for a
successful launch of Vitaros in the United Kingdom and by our other commercial
partners in Europe and Canada throughout 2014."

Mr. Pascoe continued, "Earlier today, we announced that the FDA has accepted
our Investigational New Drug application for our product candidate RayVa, and
as such, we intend to initiate a Phase 2a trial this year to assess the safety
and efficacy of RayVa in patients suffering from Raynaud's phenomenon
secondary to scleroderma. Raynaud's phenomenon secondary to scleroderma is a
disorder of the small blood vessels of the extremities. There are an estimated
100,000 adult patients with scleroderma in the US^1, of which approximately
90% have secondary Raynaud's phenomenon^3. Overall, there are approximately
500,000 adult patients with secondary Raynaud's phenomenon in the United
States.^2,3 We believe that the initiation of the RayVa development program
this year reflects our continued commitment to bringing novel therapeutics to
patients and healthcare providers in areas of high unmet medical need, while
creating long-term value for our shareholders."

Recent Developments

  *Takeda launched its Vitaros sampling program in the United Kingdom to key
    opinion leaders in advance of their full commercial launch anticipated in
    June;
  *Received FDA clearance to begin clinical studies of RayVa, a combination
    of alprostadil, a vasodilator and Apricus' proprietary permeation enhancer
    DDAIP.HCl, applied as an on-demand topical cream to affected extremities,
    which is being developed for Raynaud's phenomenon;
  *Signed an exclusive license agreement with Recordati to market Vitaros in
    Spain, Russia, Turkey and other global territories in a deal valued at up
    to $51 million;
  *Strengthened the Company's leadership with the addition of Wendell
    Wierenga, Ph.D. to Apricus' Board of Directors and the appointment of Neil
    Morton as Vice President, Business Development;
  *Manufactured and shipped commercial and sample batches of Vitaros to our
    partner Takeda in the United Kingdom;
  *Received National Phase approvals for Vitaros in Belgium, Luxembourg and
    Spain; and
  *Co-sponsored a symposium with Apricus' European commercialization partners
    on Vitaros titled "A New Paradigm in the Treatment of ED - The Topical
    Option" during the European Association of Urology (EAU) Congress.

Anticipated 2014 Milestones

  *Partner launches of Vitaros in Europe and Canada;
  *Complete the development of the Vitaros room temperature device;
  *Initiate the RayVa Phase 2a clinical trial in patients with Raynaud's
    phenomenon secondary to scleroderma, in the second half of 2014; and
  *Out-license Femprox^® in Europe.

First Quarter 2014 and Full-Year 2013 Financial Results

Net loss for the first quarter ended March 31, 2014 decreased to $3.3 million,
or $0.09 per share, compared to a net loss of $8.7 million, or $0.29 per share
for the first quarter ended March 31, 2013.

As of March 31, 2014, cash and cash equivalents totaled $22.5 million,
compared to $21.4 million as of December 31, 2013.This includes $4.7 million
received in cash for up-front license fees related to the recent Vitaros
European license agreements.

2014 Financial Outlook

In 2014, Apricus expects to generate cash from the potential out-license of
Femprox and late in 2014, expects to begin to realize initial royalty revenues
from partner sales of Vitaros. Apricus' expenditures in 2014 will include
costs supporting the further development of the Vitaros room temperature
device, the commercialization and launch of Vitaros in Europe, and the start
of new clinical development programs.

Apricus believes it has an appropriate level of cash now to support the
current operating plan into the second quarter of 2015, which includes
conducting the RayVa Phase 2a clinical trial.

Conference Call Details

Apricus will host a live conference call and webcast today at 5 p.m. Eastern
Time to discuss the Company's financial results and provide a corporate
update.To participate by telephone, please dial 877-407-9210 (Domestic) or
201-689-8049 (International). The conference ID number is 13580814. The live
audio webcast can be accessed via the following link:
http://www.investorcalendar.com/IC/CEPage.asp?ID=172650 or on the Company's
website at www.apricusbio.com. A replay of the call will be available by
dialing 877-660-6853 (Domestic) or 201-612-7415 (International). The archived
webcast will remain available for three months following the live call.

About Apricus Biosciences, Inc.

Apricus Biosciences, Inc. (APRI) is a pharmaceutical company focused on the
development and commercialization of novel therapeutics for men's and women's
health. The Company's lead product, Vitaros^®, for the treatment of erectile
dysfunction, is approved in Europe and Canada and will be commercialized by
Apricus' marketing partners, which include Abbott Laboratories Limited, Takeda
Pharmaceuticals International GmbH, Hexal AG (Sandoz), Recordati Ireland Ltd.
(Recordati S.p.A.), Bracco S.p.A. and Laboratoires Majorelle. The Company's
second-generation Vitaros room temperature device is under development and is
expected to enhance the product's commercial value.Femprox^®, the Company's
product candidate for the treatment of female sexual interest/arousal
disorder, has successfully completed an approximately 400-subject
proof-of-concept study. The Company is currently seeking a strategic partner
for Femprox.RayVa^™, the Company's product candidate for the treatment of
Raynaud's phenomenon, recently received FDA clearance to begin clinical
studies.The Company intends to begin a Phase 2a trial with RayVa in the
second half of 2014.

For further information on Apricus, visit http://www.apricusbio.com.

Forward-Looking Statements

This press release contains forward-looking statements within the meaning of
the Private Securities Litigation Reform Act, as amended.Statements in this
press release that are not purely historical are forward-looking statements.
Such forward-looking statements include, among other things: references to
the timing of planned launches of Vitaros^® in various countries by Apricus'
commercial partners, particularly the United Kingdom, the planned commencement
of a Phase 2a clinical trial for RayVa™ and the planned out-license of
Femprox^® in Europe; the potential for Vitaros to achieve commercial success
generally or in any specific territory; and the Apricus' 2014 financial
outlook, including cash projections. Actual results could differ from those
projected in any forward-looking statements due to a variety of reasons that
are outside the control of the Company, including, but not limited to: its
ability to further develop its product Vitaros for the treatment of ED, such
as the room temperature version of Vitaros, and its product candidate RayVa
for the treatment of Raynaud's phenomenon, as well as the timing of such
events; Apricus' ability to carry out clinical studies for RayVa, as well as
the timing and success of the results of such studies; Apricus' dependence on
its commercial partners to carry out the commercial launch of Vitaros in
various territories, and the potential for delays in the timing of commercial
launch; competition in the ED market and other markets in which Apricus and
its partners operate; Apricus' ability to obtain and maintain intellectual
property protection for Vitaros; Apricus' ability to raise additional funding
that it may need to continue to pursue its commercial and business development
plans; Apricus' ability to obtain the requisite governmental approval for
Femprox and RayVa; and market conditions.These forward-looking statements are
made as of the date of this press release, and Apricus assumes no obligation
to update the forward-looking statements, or to update the reasons why actual
results could differ from those projected in the forward-looking statements.
Readers are urged to read the risk factors set forth in the Company's most
recent annual report on Form 10-K, subsequent quarterly reports filed on Form
10-Q, and other filings made with the SEC. Copies of these reports are
available from the SEC's website at www.sec.gov or without charge from the
Company.

^1 Barnes J and Mayes MD. Epidemiology of systemic sclerosis: incidence,
prevalence, survival, risk factors, malignancy, and environmental triggers.
Curr Opin Rheumatol 2012, 24:165–170.American College of Rheumatology
(http://www.rheumatology.org/Practice/Clinical/Patients/Diseases_And_Conditions/Scleroderma).

^2 Pope JE. The Diagnosis and Treatment of Raynaud's Phenomenon. Drugs 2007;
67: 517-525.

^3 2012 U.S. Census Bureau: State and County QuickFacts
(http://quickfacts.census.gov/qfd/states/00000.html).

Apricus Biosciences, Inc. and Subsidiaries
Condensed Consolidated Balance Sheets (Unaudited)
(In thousands)
                                         March 31,      December 31,
                                         2014           2013
Assets                                                    
Cash and cash equivalents                 $22,491        $21,405
Property and equipment, net               1,360           955
Other current and non-current assets      1,143           950
                                                         
Total assets                              $24,994        $23,310
                                                         
Liabilities and stockholders' equity                      
Convertible notes payable, net            $2,659         $2,600
Deferred revenue                         5,454           1,800
Deconsolidation of French subsidiaries    2,846           2,846
Other current and non-current liabilities 5,145           5,092
                                                         
Total liabilities                         16,104          12,338
                                                         
Total stockholders' equity                8,890           10,972
                                                         
Total liabilities and stockholders'       $24,994        $23,310
equity
                                                         
As of March 31, 2014, the Company has 37,855,072 shares of common stock
outstanding.
                                                         
These financial statements were derived from the Company's Consolidated
Financial Statements as filed in its March 31, 2014 Report on Form 10-Q.
                                                         
                                                         

Apricus Biosciences, Inc. and Subsidiaries
Condensed Consolidated Statements of Operations (Unaudited)
(In thousands, except share and per share data)
                                                            
                                          Three Months EndedMarch 31,
                                          2014               2013
                                                            
License fee revenue                        $--             $32
Product sales                              --               15
Contract service revenue                   --               882
Total revenue                              --               929
Cost of product sales                      --               4
Cost of service revenue                    --               1,847
Gross profit (loss)                        --               (922)
                                                            
Costs and expenses, net                                      
Research and development                   1,444             1,413
General and administrative                 3,059             3,826
Gain on contract settlement                (910)             --
(Recovery) loss on sale of subsidiary      (50)              --
Total costs and expenses, net              3,543             5,239
                                                            
Loss from continuing operations before     (3,543)           (6,161)
other income (expense)
                                                            
Total other income (expense)               281               (789)
Loss from continuing operations            (3,262)           (6,950)
Income (loss) from discontinued operations --               (1,723)
                                                            
Net loss                                   $(3,262)         $(8,673)
                                                            
Basic and diluted loss per common share                      
Loss per share from continuing operations  $(0.09)          $(0.23)
Loss per share from discontinued           $--             $(0.06)
operations
                                                            
Net loss per share                         $(0.09)          $(0.29)
                                                            
Weighted average common shares outstanding 37,872,179        30,178,265
used for basic and diluted loss per share
                                                            
These financial statements were derived from the Company's Consolidated
Financial Statements as filed in its March 31, 2014 Report on Form 10-Q.
                                                            

CONTACT: Steve Martin
         Apricus Biosciences
         Chief Financial Officer
         ir@apricusbio.com
         (858) 222-8041
        
         Investors:
         Angeli Kolhatkar
         Burns McClellan
         Senior Vice President
         akolhatkar@burnsmc.com
         (212) 213-0006

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