Agilent Technologies Thought Leader Award Supports Dr. Joshua Rabinowitz’s Research at Princeton University

  Agilent Technologies Thought Leader Award Supports Dr. Joshua Rabinowitz’s
  Research at Princeton University

Team Developing LC/MS Methods, Bioinformatics Tools for Discovery of Metabolic
                            Regulatory Mechanisms

Business Wire

SANTA CLARA, Calif. -- April 17, 2014

Agilent Technologies Inc. (NYSE: A) today announced that Joshua Rabinowitz,
M.D., Ph.D., professor at Princeton University’s Department of Chemistry and
the Lewis-Sigler Institute for Integrative Genomics, has received an Agilent
Thought Leader Award to support his work on quantitative analysis of cellular

Dr. Rabinowitz is a world-renowned scientist who has made seminal conceptual
and methodological contributions to the metabolomics field. These include the
development of isotopic labeling, sample preparation, data analysis, and
information visualization techniques for liquid chromatography/mass
spectrometry data. Together these techniques allow researchers to piece
together static snapshots of metabolite levels provided by LC/MS into an
understanding of dynamic metabolic activity in living systems. Dr. Rabinowitz
has applied these tools to identify metabolic remodeling in infectious disease
and cancer pathogenesis. The resulting understanding has led to new targets
for therapeutic intervention.

“We are very happy to expand our work with Dr. Rabinowitz and his team to
support their efforts developing quantitative proteomics methodologies and
pan-omics studies of metabolism,” said John Fjeldsted, Agilent’s director of
Mass Spectrometry Research and Development. “We believe this work will have a
significant impact in many fundamental areas of research.”

The Agilent award will support Dr. Rabinowitz’s research on global cell
metabolism and its regulation. He will make use of the quantitative
capabilities of the Agilent 6550 MS-QTOF to generate protein stability
information to supplement transcriptomics, proteomics, metabolomics, and
metabolic flux data sets. From protein abundances and stabilities, he will be
able to infer protein fluxes and thereby assemble an integrative understanding
of how protein levels are regulated and how this ties into overall cellular
metabolic activity.

“I am delighted to be working with Agilent, whose combined expertise in wet
chemistry, instrumentation and software makes them an outstanding partner for
my lab,” said Dr. Rabinowitz. “We share Agilent’s goal of enabling
quantitative measurement of all key biomolecules, and of building
computational tools that integrate such data to reveal new principles of
living systems. Such tools hold the potential to revolutionize biomedical

The Agilent Thought Leader Award promotes fundamental scientific advances by
contributing financial support, products and expertise to the research of
influential thought leaders in life sciences and chemical analysis.
Information about previous award recipients is available at Agilent’s Thought
Leader Program website.

The Lewis-Sigler Institute for Integrative Genomics

The Lewis-Sigler Institute for Integrative Genomics, housed in the Carl Icahn
Laboratory at Princeton University, was established to innovate in research
and teaching at the interface of modern biology and the more quantitative
sciences. The Institute is the hub of the Center for Quantitative Biology,
funded by the National Institute of General Medical Sciences, one branch of
the National Institutes of Health.

About Agilent Technologies

Agilent Technologies Inc. (NYSE: A) is the world’s premier measurement company
and a technology leader in chemical analysis, life sciences, diagnostics,
electronics and communications. The company’s 20,600 employees serve customers
in more than 100 countries. Agilent had revenues of $6.8 billion in fiscal
2013. Information about Agilent is available at

On Sept. 19, 2013, Agilent announced plans to separate into two publicly
traded companies through a tax-free spinoff of its electronic measurement
business. The new company is named Keysight Technologies, Inc. The separation
is expected to be completed in early November 2014.

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Agilent Technologies Inc.
Susan Berg, +1 408-553-7093
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