SHIRE PLC: Total Voting Rights

 Total Voting Rights  April 1, 2014 - Shire plc (LSE: SHP, NASDAQ: SHPG) (the "Company"), in accordance with the Financial Conduct Authority's (the "FCA") Disclosure and Transparency Rule 5.6.1R, notifies the market of the following:  At close of business on March 31, 2014, the Company's issued ordinary share capital comprised 588,893,971 ordinary shares of 5 pence each with voting rights and a further 9,019,832 ordinary shares held in treasury.  Therefore the total number of voting rights in the Company is 588,893,971. This is the figure which should be used by shareholders as the denominator for the calculations by which they will determine if they are required to notify their interest in, or a change to their interest in, the Company under the FCA's Disclosure and Transparency Rules.  Tony Guthrie Deputy Company Secretary  For further information please contact:  Investor Relations                                                                                                                                           Laurie Stelzer                          lstelzer@shire.com   +1 781 482 0733    Eric Rojas                              erojas@shire.com     +1 781 482 0999    Sarah Elton-Farr                        seltonfarr@shire.com +44 1256 894157     Notes to editors  Shire enables people with life-altering conditions to lead better lives.  Our strategy is to focus on developing and marketing innovative specialty medicines to meet significant unmet patient needs.  We provide treatments in Neuroscience, Rare Diseases, Gastrointestinal and Internal Medicine and we are developing treatments for symptomatic conditions treated by specialist physicians in other targeted therapeutic areas.  Registered in Jersey, No. 99854, 22 Grenville Street, St Helier, Jersey JE4 8PX  Press Release                                                                                      www.shire.com                                       END 
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