SHIRE PLC: Director/PDMR Shareholding

 Director/PDMR Share Dealings  March 31, 2014 - Shire plc (LSE: SHP, NASDAQ: SHPG) (the "Company") announces that today Ordinary Shares ("Shares") and American Depository Shares ("ADSs") of the Company, as set out below, have been acquired for the Non-Executive Directors, being the part of their total fees that are paid in securities for the period of service from January 1 to March 31, 2014.                      Type of Security (1)      Number of Securities                                                                       Dominic Blakemore              Shares                           147                                                                          William Burns                  Shares                           178                                                                          Dr. Steven Gillis               ADSs                             57                                                                          Dr. David Ginsburg              ADSs                             54                                                                          David Kappler                  Shares                           186                                                                          Susan Kilsby                    ADSs                             61                                                                          Anne Minto                     Shares                           185                                                                          David Stout                     ADSs                             59      (1) One ADS is equal to three Shares  The Shares and ADSs were acquired on the London Stock Exchange and NASDAQ respectively at prices of £29.9876 per Share and $147.90 per ADS.  This notification relates to disclosures made in accordance with 3.1.4(R)(1)(a) of the Disclosure and Transparency Rules.  Tony Guthrie Deputy Company Secretary  For further information please contact:  Investor Relations                                                                                                                                           Laurie Stelzer                          lstelzer@shire.com   +1 781 482 0733                                                                                 Eric Rojas                              erojas@shire.com     +1 781 482 0999                                                                                 Sarah Elton-Farr                        seltonfarr@shire.com +44 1256 894157     Notes to editors  Shire enables people with life-altering conditions to lead better lives.  Our strategy is to focus on developing and marketing innovative specialty medicines to meet significant unmet patient needs.  We provide treatments in Neuroscience, Rare Diseases, Gastrointestinal and Internal Medicine and we are developing treatments for symptomatic conditions treated by specialist physicians in other targeted therapeutic areas.  www.shire.com                                                                           Registered in Jersey, No. 99854, 22 Grenville Street, St Helier, Jersey JE4 8PX  Press Release                                                                                      www.shire.com                                       END 
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