SHIRE PLC: Director/PDMR Shareholding

Director/PDMR Share Dealings 
March 31, 2014 - Shire plc (LSE: SHP, NASDAQ: SHPG) (the "Company") announces
that today Ordinary Shares ("Shares") and American Depository Shares ("ADSs")
of the Company, as set out below, have been acquired for the Non-Executive
Directors, being the part of their total fees that are paid in securities for
the period of service from January 1 to March 31, 2014. 
                    Type of Security (1)      Number of Securities  
Dominic Blakemore              Shares                           147     
William Burns                  Shares                           178     
Dr. Steven Gillis               ADSs                             57     
Dr. David Ginsburg              ADSs                             54     
David Kappler                  Shares                           186     
Susan Kilsby                    ADSs                             61     
Anne Minto                     Shares                           185     
David Stout                     ADSs                             59     
(1) One ADS is equal to three Shares 
The Shares and ADSs were acquired on the London Stock Exchange and NASDAQ
respectively at prices of £29.9876 per Share and $147.90 per ADS. 
This notification relates to disclosures made in accordance with 3.1.4(R)(1)(a)
of the Disclosure and Transparency Rules. 
Tony Guthrie
Deputy Company Secretary 
For further information please contact: 
Investor Relations                                                              
Laurie Stelzer                   +1 781 482 0733    
Eric Rojas                         +1 781 482 0999    
Sarah Elton-Farr               +44 1256 894157    
Notes to editors 
Shire enables people with life-altering conditions to lead better lives. 
Our strategy is to focus on developing and marketing innovative specialty
medicines to meet significant unmet patient needs. 
We provide treatments in Neuroscience, Rare Diseases, Gastrointestinal and
Internal Medicine and we are developing treatments for symptomatic conditions
treated by specialist physicians in other targeted therapeutic areas. 
Registered in Jersey, No. 99854, 22 Grenville Street, St Helier, Jersey JE4 8PX 
Press Release                                      
-0- Mar/31/2014 15:25 GMT
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