miRagen Therapeutics Expands Executive Leadership Team Adding Drug Development Veteran

  miRagen Therapeutics Expands Executive Leadership Team Adding Drug   Development Veteran  Dr. David Rodman Joins as Executive Vice President of Research and Development  Business Wire  BOULDER, Colo. -- March 25, 2014  miRagen Therapeutics, Inc., a biopharmaceutical company discovering and developing innovative microRNA (miRNA)-targeting therapeutics, today announced the appointment of David Rodman, M.D. to the position of Executive Vice President of Research and Development. Dr. Rodman is an accomplished industry veteran who brings significant translational medicine and clinical development experience to the company’s executive leadership team.  “Dr. Rodman is a recognized leader in innovative drug development approaches. His addition to our executive management team coincides with an important period at miRagen as we plan for the advancement of programs from discovery research into clinical development,” said William S. Marshall, Ph.D., President and Chief Executive Officer. “We believe miRagen is well positioned to capitalize on our cutting edge research as we continue to transition promising projects into clinical evaluation. I’m very pleased that Dr. Rodman will be helping to bring important medicines to patients in need.”  Dr. Rodman has more than 25 years of experience in “bench to bedside” research. He is an elected member of the American Society for Clinical Investigation, was named a Fellow and Established Investigator of the American Heart Association, and was a founding member of the Cystic Fibrosis Therapeutics Development Network. Prior to joining miRagen, Dr. Rodman was a Vice President of Clinical Development at Vertex Pharmaceuticals Incorporated, and before that he was Executive Director, Respiratory Translational Medicine at the Novartis Institutes for Biomedical Research. Dr. Rodman, who was a tenured Professor of Medicine at the University of Colorado, holds a medical degree from the University of Pennsylvania and has authored more than 100 publications.  Dr. Rodman has led cross-functional teams across the R&D spectrum from basic cell and molecular biology, through first-in-human proof-of-concept trials, to successful pivotal trials. The teams he has led have delivered multiple successful IND and CTA applications in the US, Europe and developing countries. While at Vertex, teams he led participated in the development of Vertex’s portfolio of approved and investigational cystic fibrosis medicines, which have all received Breakthrough Therapy Designation from the U.S. FDA.  “With a pipeline of innovative micro-RNA programs and a focus on diseases with high unmet medical need, I believe miRagen is well positioned to successfully translate microRNA biology into RNA-based therapies for individuals suffering from rare and neglected diseases,” said Dr. Rodman. “I am excited to join this talented team and be part of the next stage in the development of miRagen Therapeutics.”  About microRNAs  MicroRNAs have emerged as an important class of small RNAs encoded in the genome, acting as master regulators of gene expression. Recent studies have indicated that microRNAs appear to be associated with many disease processes. Because they are thought to be single molecular entities that dictate the expression of fundamental regulatory pathways, microRNAs represent potential drug targets for controlling many biologic and disease processes.^1  About miRagen Therapeutics, Inc.  miRagen Therapeutics, Inc., is a biopharmaceutical company focused on the discovery and development of innovative microRNA (miRNA)-targeting therapies, specifically in disease areas of high unmet medical need. The company seeks to leverage in-house expertise in miRNA biology, oligonucleotide chemistry, and drug development to evaluate and advance promising technologies and high-potential drug candidates for its own pipeline and in conjunction with strategic partners. For certain cardiovascular disease programs, miRagen has partnered with Servier, a leading private European pharmaceutical company. miRagen retains all rights for the Servier-partnered programs in the United States and Japan. With its commercial and academic alliances, miRagen seeks to harness the power of microRNA biology by translating discoveries into breakthrough therapies that have the potential to improve human health. For more information, please visit www.miragenrx.com.    1)   Mendell, J.T. and Olson, E.N. (2012). MicroRNAs in Stress Signaling            and Human Disease. Cell 148, 1172-1187.  Contact:  miRagen: Kecia Carroll, 720-933-0848 Communications Kecia@kcroberg.com  
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