3M Introduces the Emphaze AEX Hybrid Purifier

  3M Introduces the Emphaze AEX Hybrid Purifier

  Laboratory and Scale-up Single Use Capsules available mid-2014; Production
                         Capsules available late 2014

INTERPHEX 2014

Business Wire

ST. PAUL, Minn. -- March 17, 2014

3M Purification will unveil a new purification technology at INTERPHEX 2014
designed to help biopharmaceutical manufacturers achieve high product purity
early in the manufacturing process, improving efficiency and process
economics. The new 3M™ Emphaze™ AEX Hybrid Purifier combines three unique 3M
technologies — advanced polymer materials, fine fiber nonwovens, and membranes
— to deliver an all-synthetic clarifying product line containing both a novel
anion exchange nonwoven media, and a fine particle, bioburden reduction
membrane. The Emphaze AEX Hybrid Purifier Laboratory and Scale-up capsules
will be launched in mid-2014, with the Production capsules to be launched at
the end of the year.

The new 3M(TM) Emphaze(TM) AEX Hybrid Purifier combines three unique 3M
technologies - advanced poly ...

The new 3M(TM) Emphaze(TM) AEX Hybrid Purifier combines three unique 3M
technologies - advanced polymer materials, fine fiber nonwovens, and membranes
- to deliver an all-synthetic clarifying product line containing both a novel
anion exchange nonwoven media, and a fine particle, bioburden reduction
membrane (Photo: Business Wire).

“The Emphaze™ AEX Hybrid Purifier is a multi-mechanism clarifying device,”
said Tom Martin, Global Business Manager, Life Sciences Process Technologies,
3M Purification. “This product actually represents a new class of clarifying
products, with an all-synthetic construction, substantial chromatographic
capability, and a defined 0.2 μm pore size.”

The product is an integral combination of two types of media (Q-functional
nonwoven and membrane) that work together to provide unsurpassed product
purity after clarification when using a single unit operation. The defined
pore size of the qualifying membrane provides tremendous removal of insoluble
particles well below 0.1 µm in size, resulting in superior turbidity
reduction. At the same time, the high chromatographic capacity of the
Q-functional nonwoven provides substantial reduction of negatively charged,
soluble impurities including DNA and HCP. This combination of attributes
allows the hybrid purifier to provide superior product purity before and, most
importantly, after the protein A column, enabling a novel and simple post
protein A mAb purification process.

“We designed the Emphaze™ AEX Hybrid Purifier to provide the highest possible
level of product protein purity early in biopharmaceutical downstream process.
What is truly exciting is that by targeting the removal of particularly
problematic impurities from entering the protein A column, a profound impact
on the entire downstream process can be realized,” said Greg Jellum, Global
Laboratory Manager, Life Sciences Process Technologies, 3M Purification. “This
new product platform is a tremendous demonstration that 3M’s materials-based
technology engine will enable true innovation for our industry.”

The Emphaze AEX Hybrid Purifier offers a loading capacity similar to fine
grades of highly-charged conventional depth filters, and can easily be
incorporated into existing manufacturing processes where such a depth filter
would be used. The Emphaze AEX Hybrid Purifier will be encapsulated in 3M’s
signature single-use capsule design, thereby providing the opportunity to
minimize capital in a matched component harvest solution. By providing the
best possible protection of valuable downstream unit processes, the technology
holds significant potential for improving efficiency in the production of mAb
drugs for conditions including various cancers, as well as autoimmune diseases
like rheumatoid arthritis and Psoriasis.

3M Purification representatives will be available to discuss the new product
at INTERPHEX at booth number 2145. INTERPHEX 2014 will be held at the Javits
Center in New York City, March 18-20, 2014.

For more information, visit 3Mpurification.com/Emphaze

About 3M
3M captures the spark of new ideas and transforms them into thousands of
ingenious products. Our culture of creative collaboration inspires a
never-ending stream of powerful technologies that make life better. 3M is the
innovation company that never stops inventing. With $31 billion in sales, 3M
employs 89,000 people worldwide and has operations in more than 70 countries.
For more information, visit www.3M.com or follow @3MNews on Twitter.

3M and Emphaze are trademarks of 3M Company.

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http://www.businesswire.com/multimedia/home/20140317006249/en/

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Available:http://www.businesswire.com/cgi-bin/mmg.cgi?eid=50826434&lang=en

Contact:

Karwoski & Courage Public Relations
Kristin Merchant, 612-342-9721
k.merchant@creativepr.com
 
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