Hepatitis C treatment guidelines Markets to 2019 - Market Shares, Strategies,
and Forecasts Report Available Online By ResearchMoz.us
ALBANY, New York, February 19, 2014
ALBANY, New York, February 19, 2014 /PRNewswire/ --
ResearchMoz.us includes new market research report " Hepatitis C Therapeutics
in Major Developed Markets to 2019 " to its huge collection of research
Researchmoz presents this most up-to-date research on Hepatitis C Therapeutics
in Major Developed Markets to 2019 (
). GBI Research, has released the pharma report - "Hepatitis C Therapeutics in
Major Developed Markets to 2019 - Outstanding Recent Approvals and Late-Stage
Pipeline to Transform Clinical and Commercial Landscape". The current
Hepatitis C treatment landscape consists of a combination of pegylated
interferon, ribavirin and, in patients infected with genotype 1 hepatitis C,
one of two direct-acting antiviral agents (DAAs). Products with these
mechanisms of action have performed strongly in the commercial setting, with
the market leader Incivek (a DAA) having reached blockbuster sales. However,
these products are very poorly tolerated and only moderately efficacious. The
approval of the DAA Sovaldi in December 2013 changed this, with a complete
viral clearance being achieved in close to 100% of patients and a much
improved adverse event profile compared to previous standards of therapy. In
patients with genotype 2 and 3 hepatitis C, Sovaldi does not need to be
administered with pegylated interferon. A number of products in the late-stage
pipeline, which promise to be even more efficacious and safe are anticipated
to enter the market over the forecast period, including several
interferon-free therapies for genotype 1-infected patients. As a result of
this, as well as an overall increase in the treated population, GBI Research
believes the global market has the potential to grow to a value of $18.6
billion by 2019, more than tripling the 2012 market value of $5.8 billion.
A brief introduction to hepatitis C, including the disease's pathogenesis,
risk factors and diagnosis, and detailed analyses of disease epidemiology and
In-depth analysis of the major antiviral drugs used in the treatment of
hepatitis C, including analyses of their safety, efficacy, treatment patterns
and strengths/weaknesses. Includes a heat map that compares marketed drugs in
terms of safety and efficacy.
A comprehensive review of the pipeline for hepatitis C therapies, including
individual analysis of a number of late-stage pipeline drugs that are likely
to enter the market during the forecast period. The pipeline is analyzed by
phase distribution, molecule type and molecular target.
In-depth clinical trial enrolment, trial duration and program failure rate
analyses for each molecule type and mechanism of action. Additionally,
clinical trial endpoints and certain selection criteria are analyzed in great
depth. This section also includes an additional heat map regarding pipeline
products, and a direct cross-analysis against currently marketed products.
Multi-scenario forecast data of the market to 2019, which takes into account
the effects of the introduction of new drugs, the expiry of key patents on
current drugs and the changes in disease epidemiology across the key developed
markets: US, Canada, Japan, Germany, UK, France, Italy and Spain.
Discussion of the drivers and barriers for market growth.
Analysis of licensing and co-development deals occurring in the hepatitis C
Reasons to Buy
Understand the different types of hepatitis C therapies and how treatment
varies by genotype.
Understand the treatment algorithms and guidelines related to hepatitis C, how
they are anticipated to change during the forecast period and where
opportunities and unmet needs lie.
Understand the vast scope of the pipeline, including which molecule types and
mechanisms of action are most prominent.
Observe trends in clinical trial duration and size as clinical phase and
molecule type varies. Use the clinical trial failure rate analysis to assess
the risk profiles of current and/or future developmental programs for
hepatitis C therapeutics.
Observe the shift in clinical trial endpoints with each clinical Phase, and
use this data to potentially influence any future developmental programs.
Additionally, understand the trends in enrolment by patient genotype.
Assess the potential clinical and commercial impact of current late-stage
pipeline molecules and the points of opportunity which remain to be
Table of Contents 1 Table of Contents 1.1 List of Tables 1.2 List of Figures
2 Introduction 2.1 Signs and Symptoms 2.2 Etiology and Risk Factors 2.3
Pathophysiology 2.4 Epidemiology 2.4.1 US and Canada 2.4.2 Europe 2.4.3 Japan
2.4.4 Regional Prevalence of Hepatitis C Genotypes 2.5 Prognosis 2.6 Diagnosis
and Screening 2.7 Treatment 2.8 Treatment Algorithms
3 Marketed Products 3.1 Ribavirin 3.2 Pegasys (Peginterferon alfa 2a) and
PegIntron (Peginterferon alfa 2b) - Hoffmann La Roche and Merck & Co 3.2.1
Pegasys - Hoffmann La Roche 3.2.2 PegIntron - Merck & Co 3.3 Incivek
(telaprevir) - Vertex Pharmaceuticals and Janssen-Cilag 3.4 Victrelis
(boceprevir) - Merck & Co 3.5 Olysio (simeprevir) - Johnson and Johnson 3.6
Sovaldi (sofosbuvir) - Gilead Sciences 3.7 Heat Map for Marketed Products
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