Mannatech Announces Publication of Ambrotose Complex Powder Trial

  Mannatech Announces Publication of Ambrotose Complex Powder Trial

            Study finds that Ambrotose Complex can improve memory

Business Wire

COPPELL, Texas -- February 12, 2014

Mannatech, Incorporated  (NASDAQ: MTEX), the founder of the M5M^SM (Mission 5
Million^SM) social entrepreneurial movement, the pioneer of glycobiology and
the leading innovator of naturally-sourced supplements based on Real Food
Technology^® solutions, announced today the publication of a randomized,
double-blind, placebo-controlled human clinical trial showing that intake of a
single serving of Ambrotose^® complex powder can improve memory.*^1

In this study, 73 healthy, mentally fatigued middle-aged adults taking
Ambrotose complex experienced statistically significant improvements in their
performance on a battery of tests assessing cognitive function, without
affecting blood glucose levels.* The study was led by Dr. Talitha Best, a
post-doctoral research fellow at the Nutritional Physiology Research Centre,
Sansom Institute for Health Research, University of South Australia (UniSA).**

“While the majority of older Americans take dietary supplements to support
overall wellness and healthy aging, they are aware of age-related memory
problems but haven’t found a supplement that they believe will help,”
commented Dr. Robert Sinnott, Mannatech’s CEO and Chief Science Officer. “This
study makes it clear that consumers have a product, now backed by three
double-blind, placebo-controlled trials, that can provide significant
cognitive benefits, both after a single serving^1 and long-term intake.” ^ 2,
3

While neuropsychological testing indicates that declines in some aspects of
memory function can be detectable as early as one’s 20s and 30s, most people
start noticing memory issues about age 50 and thereafter. Given the
rapidly-growing number of adults aged 65 and older in the developed
world—seniors comprise over 13% of the population in the U.S., Canada and
Australia, and 25% of the population in Japan—the need for validated, safe
dietary supplements to support healthy cognitive function, a cornerstone of
the quality of life, is exploding.

“A healthy lifestyle —one that includes exercise, a healthy diet, no more than
moderate alcohol intake, staying mentally active, managing stress, getting
adequate sleep, not smoking and staying socially active—can help optimize
cognitive function throughout life,” continued Dr. Sinnott. “Our patented,
clinically validated Ambrotose products, which have been safely consumed for
almost 20 years, are a great choice for people who want to get the most out of
their golden years.”

Individuals interested in Mannatech’s products, or exploring its social
entrepreneurial efforts to help fight global malnutrition, can learn more at
Mannatech.com.

1. Best T, Howe P, Bryan J, Buckley J, Scholey A. Acute effects of a dietary
non-starch polysaccharide supplement on cognitive performance in healthy
middle-aged adults. Nutr Neurosci 2014;1-11.

2. Best T, Kemps E, Bryan J. Saccharide effects on cognition and well-being in
middle-aged adults: A randomized controlled trial. Dev Neuropsych
2010;35:66-80.

3. Best T. An investigation of saccharide effects on memory performance.
Abstracts of the 12th Annual Australian Psch Conf 2005;57.

* This statement has not been evaluated by the Food and Drug Administration.
This product is not intended to diagnose, treat, cure or prevent any disease.

**Mannatech provided partial funding, and the Ambrotose supplement and
placebo, used in this study.

About Mannatech

Mannatech, Incorporated, develops high-quality health, weight and fitness, and
skin care products that are based on the solid foundation of nutritional
science and development standards. Mannatech is dedicated to its platform of
Social Entrepreneurship based on the foundation of promoting, aiding and
optimizing nutrition where it is needed most around the world. Mannatech’s
proprietary products are available through independent sales Associates around
the globe including the United States, Canada, South Africa, Australia, New
Zealand, Austria, Denmark, Germany, Norway, Sweden, the Netherlands, the
United Kingdom, Japan, Taiwan, Singapore, Estonia, Finland, the Republic of
Ireland, Czech Republic, the Republic of Korea, Mexico, Namibia, Hong Kong and
Ukraine. For more information, visit Mannatech.com.

Please note: This release contains “forward-looking statements” within the
meaning of Section 27A of the Securities Act of 1933, as amended, Section 21E
of the Securities Exchange Act of 1934, as amended, and the Private Securities
Litigation Reform Act of 1995. These forward-looking statements generally can
be identified by use of phrases or terminology such as “intend” or other
similar words or the negative of such terminology. Similarly, descriptions of
Mannatech’s objectives, strategies, plans, goals or targets contained herein
are also considered forward-looking statements. Mannatech believes this
release should be read in conjunction with all of its filings with the United
States Securities and Exchange Commission and cautions its readers that these
forward-looking statements are subject to certain events, risks, uncertainties
and other factors. Some of these factors include, among others, Mannatech’s
inability to attract and retain Associates and Members, increases in
competition, litigation, regulatory changes and its planned growth into new
international markets. Although Mannatech believes that the expectations,
statements and assumptions reflected in these forward-looking statements are
reasonable, it cautions readers to always consider all of the risk factors and
any other cautionary statements carefully in evaluating each forward-looking
statement in this release, as well as those set forth in its latest Annual
Report on Form 10-K and Quarterly Report on Form 10-Q, and other filings filed
with the United States Securities and Exchange Commission, including its
current reports on Form 8-K. All of the forward-looking statements contained
herein speak only as of the date of this release.

Contact:

Mannatech, Incorporated
Brett Duncan, 972-471-7367
bduncan@mannatech.com
 
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