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University of Bristol Collaborates with Affymetrix on Genotyping Arrays for Guaranteed Sustainability of Wheat Production

  University of Bristol Collaborates with Affymetrix on Genotyping Arrays for
  Guaranteed Sustainability of Wheat Production

Business Wire

SANTA CLARA, Calif. -- January 13, 2014

Affymetrix, Inc. (NASDAQ: AFFX) and University of Bristol, Bristol, UK,
announced today that they have collaboratively designed a wheat genotyping
array and analyzed data from experiments as part of an effort to understand
wheat genetics and breeding with a goal of ensuring guaranteed sustainable
production.

Axiom^® Wheat Genotyping Array (Axiom Wheat Array), consisting of 817,000
markers, was designed for the University of Bristol as part of the
Biotechnology and Biological Sciences Research Council (BBSRC)-funded Wheat
Improvement Strategic Program (WISP). The aim of WISP is to produce new and
novel wheat germplasm via three complementary "pillars" (landraces,
synthetics, and ancestral gene introgression), each of which will broaden the
pool of genetic variation in elite wheat cultivars by a different route. The
design of Axiom Wheat Array is unique because it includes functional and
positional annotation information for a variety of wheat species. The SNPs on
Axiom Wheat Array include markers from hexaploid landraces and those from the
synthetic and ancestral lines exhibiting different ploidy levels. Results from
the array will be presented at the 2014 Plant and Animal Genome conference
(PAG XXII), in San Diego, California.

“The results from Axiom Wheat Array are fantastic and have helped WISP achieve
one of the main goals, which is to track the different segments of the 'wheat
relative' line and incorporate them into hexaploid bread wheat through the
breeding process. The follow-on focused arrays will offer wheat breeders the
capability to understand polymorphisms between their current breeding lines,”
stated Professor Keith Edwards, project leader and professor of Cereal
Functional Genomics at the School of Biological Sciences and member of the
Cabot Institute, University of Bristol. “We were thrilled to be able to
complete the design and analysis in less than three months and in time to
present the results at the Plant and Animal Genome meeting. This was made
possible mainly because of the expertise, commitment, and collaborative
efforts of the bioinformatics and product support teams at Affymetrix.”

“We are pleased to be able to support the goals of the University of Bristol
and contribute efforts to help sustain wheat production in the face of
challenges from a growing world population and climate change,” said Dr. Andy
Last, Executive Vice President and Chief Operating Officer at Affymetrix. “The
Axiom platform enables researchers to publish results sooner and breeders to
accelerate their genomic programs. The platform’s superior capabilities are
transforming and modernizing custom genotyping capabilities accessible to the
agricultural, scientific, and applied community at large.”

A subset of the 817,000 markers found on Axiom Wheat Array will be transferred
with 100 percent fidelity onto Axiom 384HT-format arrays to create multiple
focused wheat array designs. Each of these Axiom wheat array designs will
contain approximately 35,000 markers and each design is expected to serve a
different purpose in wheat breeding. The 384HT format enables ultra
high-throughput processing of 384 samples simultaneously and will be used to
screen thousands of samples in a highly cost-effective manner. Affymetrix will
make these new Axiom arrays publicly available before the spring wheat season.

With Affymetrix’ advanced bioinformatics and innovative design strategies,
Axiom genotyping array designs routinely support genome-wide genotyping and
accurately call the genotypes of both diploid and polyploid species.

The Axiom Wheat Genotyping arrays in the 384HT format will complement the
catalog of Axiom Genotyping Arrays for Agrigenomics that are available for
multiple species including salmon, maize, strawberry, rose, bovine, chicken,
and buffalo. These products have been used for genome-wide association
studies, quantitative trait locus mapping, genome mapping, and breeding
activities that make use of marker-assisted selection and genomic selection.
As scientists make progress in decoding genomes of various plants, animals,
and fish using next-generation sequencing platforms, they can advance their
research and commercial objectives by translating those discoveries to routine
applications on the Axiom platform.

To learn more about the Axiom Genotyping Solution, please visit
www.affymetrix.com/agrigenotyping for applications in agrigenomics.

PLEASE NOTE: Affymetrix, the Affymetrix logo, Axiom, and all other trademarks
are the property of Affymetrix, Inc. All other trademarks are the property of
their respective owners.

SOURCE: Affymetrix, Inc.

Forward-looking statements

All statements in this press release that are not historical are
"forward-looking statements" within the meaning of Section 21E of the
Securities Exchange Act as amended, including statements regarding Affymetrix'
"expectations," "beliefs," "hopes," "intentions," "strategies," or the like.
Such statements are subject to risks and uncertainties that could cause actual
results to differ materially for Affymetrix from those projected. These and
other risk factors are discussed in Affymetrix' Form 10-K for the year ended
December 31, 2012, and other SEC reports for subsequent quarterly periods.

About Affymetrix

Affymetrix technologies enable multiplex and simultaneous analysis of
biological systems at the cell, protein, and gene level, facilitating the
rapid translation of bench-top research into clinical and routine use for
human health and wellness.

The Company provides leadership and support, partnering with customers in
pharmaceutical, diagnostic, and biotechnology companies, as well as leading
academic, government, and non-profit research institutes in their quest to use
biology for a better world.

More than 2,300 microarray systems have been shipped around the world and more
than 48,000 peer-reviewed papers have been published citing Affymetrix
technologies. Affymetrix is headquartered in Santa Clara, California, and has
manufacturing facilities in Cleveland, Ohio, San Diego, Vienna, and Singapore.
The Company has about 1,100 employees worldwide and maintains sales and
distribution operations across Europe, Asia, and Latin America. For more
information about Affymetrix, please visit www.affymetrix.com.

Contact:

Affymetrix, Inc.
Media Contact:
Mindy Lee-Olsen
Vice President, Marketing Services
408-731-5523
mindy_lee-olsen@affymetrix.com
or
Investor Contact:
Doug Farrell
Vice President, Investor Relations
408-731-5285
doug_farrell@affymetrix.com
 
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