TiGenix Business Update & Financial Highlights for Q3 of 2013

TiGenix Business Update & Financial Highlights for Q3 of 2013

  *ChondroCelect: sales up 21% for first nine months and advanced discussions
    to monetize the Dutch manufacturing facility ongoing
  *Cx601: European ADMIRE-CD Phase III enrollment on schedule and partnering
    discussions ongoing for non-European territories
  *EUR 6.4 million cash on hand on September 30. Cash burn for the third
    quarter reduced to EUR 1.1 million per month

LEUVEN, Belgium, Nov. 5, 2013 (GLOBE NEWSWIRE) -- TiGenix NV (Euronext
Brussels:TIG), the European leader in cell therapy, gives an update of its
business activities and provides the financial highlights for the third
quarter ending September 30, 2013.

Business update

ChondroCelect sales on track to become cash flow positive in 2014

ChondroCelect sales for the nine months ended September 30 have grown 21% to
EUR 3.1 million, compared to EUR 2.6 million in the same period of last year
on a like-for-like basis. ChondroCelect sales for the third quarter amounted
to EUR 0.8 million. The company expects a sales growth rate above 20% for the
full year, with revenues mainly fueled by sales in Belgium and the
Netherlands.

With centers coming on stream in Spain and the UK, sales from these countries
will contribute to increased growth in 2014. All in all, sales are progressing
according to plan for ChondroCelect to become a cash flow positive asset in
the course of 2014.

TiGenix renews GMP license for Dutch manufacturing facility

In October, Dutch authorities renewed TiGenix's GMP license for its
state-of-the-art cell therapy manufacturing facility in Sittard-Geleen, the
Netherlands. This renewal allows the Company to move forward unimpeded with
its advanced negotiations to monetize the facility.

Patient enrollment on plan in ADMIRE-CD Phase III trial (Cx601) in complex
perianal fistulas

Patient enrollment in the ADMIRE-CD trial, the Company's pivotal European
Phase III clinical trial with Cx601, is progressing on plan. Recruitment is
ongoing at more than 45 centers in 8 countries. If results are positive, this
trial will allow TiGenix to file for European marketing approval of Cx601 in
2015.

Cx601 partnering discussions ongoing for non-European territories

TiGenix continues to advance discussions with a number of parties regarding
the ex-Europe commercial rights to its lead program Cx601. To maximize the
value of the asset, the company is progressing with all activities required to
move forward in the US in the near future. TiGenix has requested a pre-IND
meeting with the FDA to confirm the regulatory and clinical pathway for the
product in the US market and negotiations are ongoing to secure capacity to
manufacture Cx601 for the US clinical trial.

Cx611 clinical development plan progressing

In October, TiGenix presented the positive results of its Phase IIa study of
Cx611 in refractory rheumatoid arthritis in a plenary session of the American
College of Rheumatology Annual Meeting. Working closely together with an
advisory board of international key opinion leaders on the appropriate design
of follow-up studies for Cx611 in RA and other autoimmune disorders, TiGenix
expects to finalize the development plan before year-end. At that point the
Company will decide which indication to pursue and whether to do it alone or
with a partner.

Financial update

Capital increase of EUR 6.5 million in July 2013

The company raised EUR 6.5 million through a private placement via an
accelerated book building procedure with mainly international healthcare
specialist investors.

Cash position of EUR 6.4 million on September 30, 2013

On September 30, 2013, the Company had a cash position of EUR 6.4 million. Net
cash used during the third quarter of 2013 (excluding the impact of the
capital increase of July) was EUR 1.1 million per month, significantly below
management guidance.

"We keep diligently executing on our action plan to grow ChondroCelect sales,
monetize our Dutch manufacturing facility, focus on our lead asset Cx601,
prepare the development plan for Cx611 and secure the means to be able to
execute our strategy," said Eduardo Bravo, CEO of TiGenix. "We are making
continuous progress on each of these initiatives and we expect to communicate
on some concrete achievements in the next few weeks".

Outlook next 12 months

  *Continued ramp-up of ChondroCelect sales
  *Finalize recruitment of Cx601 phase III trial in complex perianal fistula
    in Crohn's patients
  *Partnering agreement for Cx601 for territories outside of Europe
  *Monetization of the Dutch cell therapy manufacturing facility
  *Completion of clinical development plan for Cx611
  *Strengthening of balance sheet

About TiGenix

TiGenix NV (Euronext Brussels:TIG)is a leading European cell therapy
companywith a marketed cell therapy product for cartilage repair,
ChondroCelect®, and a strongpipeline with clinical stage allogeneic adult
stem cell programsfor the treatment ofautoimmune and inflammatory
diseases.TiGenixis based out of Leuven (Belgium) and has operations in
Madrid (Spain), and Sittard-Geleen (theNetherlands). For more information
please visitwww.tigenix.com.

Forward-looking information

This document may contain forward-looking statements and estimates with
respect to the anticipated future performance of TiGenix and the market in
which it operates. Certain of these statements, forecasts and estimates can be
recognised by the use of words such as, without limitation, "believes",
"anticipates", "expects", "intends", "plans", "seeks", "estimates", "may",
"will" and "continue" and similar expressions. They include all matters that
are not historical facts. Such statements, forecasts and estimates are based
on various assumptions and assessments of known and unknown risks,
uncertainties and other factors, which were deemed reasonable when made but
may or may not prove to be correct. Actual events are difficult to predict and
may depend upon factors that are beyond TiGenix' control. Therefore, actual
results, the financial condition, performance or achievements of TiGenix, or
industry results, may turn out to be materially different from any future
results, performance or achievements expressed or implied by such statements,
forecasts and estimates. Given these uncertainties, no representations are
made as to the accuracy or fairness of such forward-looking statements,
forecasts and estimates. Furthermore, forward-looking statements, forecasts
and estimates only speak as of the date of the publication of this document.
TiGenix disclaims any obligation to update any such forward-looking statement,
forecast or estimates to reflect any change in TiGenix' expectations with
regard thereto, or any change in events, conditions or circumstances on which
any such statement, forecast or estimate is based, except to the extent
required by Belgian law.

CONTACT: For more information:
         Eduardo Bravo
         Chief Executive Officer
         eduardo.bravo@tigenix.com
        
         Claudia D'Augusta
         Chief Financial Officer
         claudia.daugusta@tigenix.com
        
         Hans Herklots
         hans.herklots@tigenix.com
         +32 16 39 60 97
 
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