SHIRE PLC: Block Listing Application

Block Listing Application 
November 4, 2013 - Shire plc (the "Company") (LSE: SHP, NASDAQ: SHPG) hereby
notifies the market that an application has been made to the UK Listing
Authority and the London Stock Exchange for a total of 1,000,000 ordinary
shares of 5p each ("Shares") to be admitted to the Official List. These Shares
are being reserved under a block listing and will be issued pursuant to the
Shire Employee Stock Purchase Plan. 
These Shares will rank pari passu in all respects with the existing issued
Shares of the Company.  
For further information please contact: 
Investor Relations                                                              
                                                                           
Eric Rojas                              erojas@shire.com     +1 781 482 0999    
                                                                           
Sarah Elton-Farr                        seltonfarr@shire.com +44 1256 894157    
NOTES TO EDITORS 
Shire enables people with life-altering conditions to lead better lives. 
Our strategy is to focus on developing and marketing innovative specialty
medicines to meet significant unmet patient needs. 
We provide treatments in Neuroscience, Rare Diseases, Gastrointestinal,
Internal Medicine and Regenerative Medicine and we are developing treatments
for symptomatic conditions treated by specialist physicians in other targeted
therapeutic areas. 
www.shire.com 
                                                                     
Registered in Jersey, No. 99854, 22 Grenville Street, St Helier, Jersey JE4 8PX 
Press Release                                      
                                              
www.shire.com                                      
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-0- Nov/04/2013 07:00 GMT