SHIRE PLC: Director/PDMR Shareholding

Director Share Dealings 
November 1, 2013 - Shire plc (LSE: SHP, NASDAQ: SHPG) announces that on
November 1, 2013, Flemming Ornskov was granted an option over American
Depository Shares ("ADSs") pursuant to the Shire Employee Stock Purchase Plan.
He has elected to save US$480.76 per fortnight. The option price will be the
lower of 85% of the fair market value of an ADS on November 1, 2013, and 85% of
the fair market value of an ADS on the exercise date, October 31, 2014. One ADS
is equal to three Shire ordinary shares of 5 pence each. 
This notification is to satisfy the Company's obligations under 3.1.4(R)(1)(a)
of the Disclosure and Transparency Rules. 
Tony Guthrie 
Deputy Company Secretary 
For further information please contact: 
Investor Relations                                                              
                                                                           
Eric Rojas                              erojas@shire.com     +1 781 482 0999    
                                                                           
Sarah Elton-Farr                        seltonfarr@shire.com +44 1256 894157    
Notes to editors 
Shire enables people with life-altering conditions to lead better lives. 
Our strategy is to focus on developing and marketing innovative specialty
medicines to meet significant unmet patient needs. 
We provide treatments in Neuroscience, Rare Diseases, Gastrointestinal,
Internal Medicine and Regenerative Medicine and we are developing treatments
for symptomatic conditions treated by specialist physicians in other targeted
therapeutic areas. 
www.shire.com 
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Registered in Jersey, No. 99854, 22 Grenville Street, St Helier, Jersey JE4 8PX 
Press Release                                      
                                              
www.shire.com                                      
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