Positive Clinical Trial Results, Patient Enrollment, and Collaborations - Research Report on Pfizer, Medivation, AbbVie, Cigna,

  Positive Clinical Trial Results, Patient Enrollment, and Collaborations -
    Research Report on Pfizer, Medivation, AbbVie, Cigna, and AstraZeneca

PR Newswire

NEW YORK, October 28, 2013

NEW YORK, October 28, 2013 /PRNewswire/ --

Editor Note: For more information about this release, please scroll to bottom.

Today, Analysts' Corner announced new research reports highlighting Pfizer
Inc. (NYSE: PFE), Medivation Inc. (NASDAQ: MDVN), AbbVie Inc. (NYSE: ABBV),
AstraZeneca plc (ADR) (NYSE: AZN), and Cigna Corporation (NYSE: CI). Today's
readers may access these reports free of charge - including full price
targets, industry analysis and analyst ratings - via the links below.

Pfizer Inc. Research Report

On October 22, 2013, Pfizer Inc. (Pfizer) announced that after achieving
technical milestones related to manufacturing, it will continue the
development program for Remoxy (oxycodone) Extended-Release Capsules CII.
Pfizer will proceed with the additional clinical studies and other actions
required to address the Complete Response Letter received in June 2011. The
Company confirmed that this comes after the guidance received from the U.S.
Food and Drug Administration in early 2013. The Company said that the new
clinical studies will include, in part, a pivotal bioequivalence study with
the modified Remoxy formulation to bridge to the clinical data related to the
original Remoxy formulation, as well as an abuse-potential study with modified
formulation. The Company said that it does not expect the complete response
submission to occur prior to mid-2015. Pfizer obtained rights to Remoxy in
February 2011 as part of its acquisition of King Pharmaceuticals, Inc., which
has an agreement with Pain Therapeutics Inc. to develop and commercialize the
drug. The Full Research Report on Pfizer Inc. - including full detailed
breakdown, analyst ratings and price targets - is available to download free
of charge at: [http://www.analystscorner.com/r/full_research_report/d702_PFE]

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Medivation Inc. Research Report

On October 22, 2013, Medivation Inc. (Medivation) and Astellas Pharma Inc.
(Astellas) announced that the Independent Data Monitoring Committee (IDMC)
informed the Companies of positive results from a planned interim analysis of
the global Phase 3 PREVAIL trial of enzalutamide in more than 1,700 men with
metastatic prostate cancer that has progressed despite androgen deprivation
therapy and who have not yet received chemotherapy. Medivation said that the
IDMC concluded that enzalutamide demonstrated a favorable benefit-risk ratio,
given the observed benefits in the trial's co-primary endpoints of overall
survival and radiographic progression-free survival, and considering the
observed safety profile. Medivation further reported that the IDMC has
recommended the study be stopped and patients treated with placebo be offered
enzalutamide. Medivation and Astellas intend to begin meetings with and
submissions to regulatory agencies starting early 2014. The Full Research
Report on Medivation Inc. - including full detailed breakdown, analyst ratings
and price targets - is available to download free of charge at:
[http://www.analystscorner.com/r/full_research_report/4277_MDVN]

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AbbVie Inc. Research Report

On October 22, 2013, AbbVie Inc.'s (AbbVie) stock rose 1.34%, ending the day
at $49.00, which is its highest closing price since the beginning of 2013.
Over the previous three trading sessions, shares of AbbVie gained 1.72%,
outperforming the S&P 500 which gained 1.24% during the same period. The Full
Research Report on AbbVie Inc. - including full detailed breakdown, analyst
ratings and price targets - is available to download free of charge at:
[http://www.analystscorner.com/r/full_research_report/273c_ABBV]

--

AstraZeneca plc (ADR) Research Report

On October 22, 2013, AstraZeneca plc (ADR) (AstraZeneca) announced the first
patient randomized in the Phase III clinical program for selumetinib, and
oral, potent, selective MEK inhibitor, being investigated as second-line
therapy in patients with advanced or metastatic non-small-cell lung cancer
(NSCLC) whose tumors are KRAS mutation-positive. The Company said that the
SELumetinib Evaluation as Combination Therapy-1 (SELECT-1) study is a
randomized, double-blind, placebo-controlled study that will evaluate the
safety and efficacy of selumetinib plus docetaxel as a second line therapy in
locally advanced or metastatic KRAS mutation-positive NSCLC. AstraZeneca
expects the study to evaluate Progression Free Survival (PFS) and Overall
Survival (OS). The Company reported that this will be the largest prospective
study ever conducted in this patient population, a genetic subtype of lung
cancer associated with poor prognosis and limited treatment options.
AstraZeneca acquired exclusive worldwide rights to selumetinib from Array
BioPharma in 2003. The Full Research Report on AstraZeneca plc (ADR) -
including full detailed breakdown, analyst ratings and price targets - is
available to download free of charge at:
[http://www.analystscorner.com/r/full_research_report/7307_CI]

--

Cigna Corporation Research Report

On October 21, 2013, Cigna Corporation (Cigna), together with The Polyclinic,
announced that the two Companies have launched a collaborative accountable
care initiative to improve patient access to health care, enhance care
coordination, and achieve the triple aim of improved health, affordability,
and patient experience. The Company said that collaborative accountable care
is part of its approach to accomplishing the same population health goals as
accountable care organizations or ACOs. The program will benefit individuals
covered by a Cigna health plan who receive care from The Polyclinic's 175
primary care doctors and specialists. Cigna added that it will compensate The
Polyclinic for the medical and care coordination services it provides.
Further, The Polyclinic may be rewarded through a "pay for value" structure if
it meets targets for improving quality and lowering medical costs. The program
became effective October 1, 2013 and is Cigna's second accountable care
initiative in the Puget Sound area. The Full Research Report on Cigna
Corporation - including full detailed breakdown, analyst ratings and price
targets - is available to download free of charge at:
[http://www.analystscorner.com/r/full_research_report/09cc_AZN]

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