OpGen and Hitachi High-Technologies Corporation Enter into an Agreement to Develop Human Chromosome Mapping Analytical Service

  OpGen and Hitachi High-Technologies Corporation Enter into an Agreement to
  Develop Human Chromosome Mapping Analytical Service

    Companies to Develop Offering that Combines Whole Genome Mapping™ with
            Cloud-Based Informatics and Data Management Platforms

Business Wire

GAITHERSBURG, Md. & TOKYO -- October 16, 2013

OpGen, Inc., a leading genetic analysis company, and Hitachi High-Technologies
Corporation today announced an agreement to develop a comprehensive human
chromosome mapping analytical service for clinical research applications by a
combination of OpGen’s market-leading Whole Genome Mapping™ technology and
Hitachi High-Technologies’ and Hitachi group’s cloud-based systems. This
service will include bioinformatics tools to complete human genome sequence,
and detect and analyze structural variations in human chromosomes.

“Hitachi High-Technologies Corporation is a global technology leader, and we
are pleased to partner with them to create an integrated solution for human
genome analysis that captures important structural variation information,”
said Douglas White, chief executive officer of OpGen, Inc. “The resulting
human chromosome mapping service will enable OpGen to continue its expansion
into clinical research with the potential to develop diagnostic applications
for diseases based on a patient’s genetic information.”

Under the terms of this agreement, Hitachi High-Technologies will fund
development, and the companies will work together to combine the strengths of
their proprietary technologies. OpGen’s Whole Genome Mapping provides a unique
view into structural variation in human chromosomes and offers a more accurate
and complete analysis of the human genome than next generation sequencing data
alone can provide. Many structural variations are associated with cancer,
autism, Alzheimer’s disease and many other cognitive disorders. This type of
genetic information will enable development of new therapies, and
eventuallywill empower the broader healthcare community to diagnose and guide
treatment decisions based on a patient’s genetic profile.

Hitachi High-Technologies, with recognized experience and achievements through
DNA sequencer business in the life science and translational research markets,
has been developing the cloud platform for human genome data analysis with
Hitachi Solutions, in Foster City, California. The human genome cloud platform
will enable secure entry portals for researchers, clinicians and eventually
patients, to access Whole Genome Mapping data, human chromosome analytical
tools and ultimately, clinically actionable data. As part of the service,
Hitachi High-Technologies also will add human DNA sequence analytical tools,
which complement Whole Genome Mapping, to provide complete genetic evaluation
of human chromosomes.

“This partnership leverages our development of the cloud-based informatics
platform and provides enabling and proven technology for human genetic
analysis,” said Takashi Matsuzaka, senior vice president and executive
officer, CTO of Hitachi High-Technologies Corporation. “This is a great
example of how Hitachi High-Technologies is continuously enhancing our
healthcare informatics offerings for customers worldwide by partnering our
technologies with other innovative companies, such as OpGen.”

OpGen and Hitachi High-Technologies/Hitachi Solutions plan to introduce more
details about the service in the Hitachi booths 811 & 813 at the American
Society of Human Genetics Annual Meeting, being held October 23-25 in Boston.

About Hitachi High-Technologies Corporation

Hitachi High-Technologies Corporation (TOKYO:8036), headquartered in Tokyo,
Japan, is engaged in activities in a broad range of fields, including
Electronic Device Systems, Fine Technology Systems, Science & Medical Systems,
Industrial & IT Systems, and Advanced Industrial Products. The company's
consolidated sales for FY 2012 were more than $6.1 billion. For further
information, visit http://www.hitachi-hitec.com/global/.

About OpGen, Inc.

OpGen, Inc. is a leading innovator in rapid, accurate genomic and DNA analysis
systems and services. The company is building on the success of its Whole
Genome Mapping™ applications in the public health and life sciences sectors to
expand its capabilities into clinical diagnostics for the growing healthcare
market. OpGen’s core, proprietary Whole Genome Mapping technology has been
demonstrated to dramatically improve the quality of data and time to results
by providing complete genome maps more rapidly and less expensively than
previously possible. Its Whole Genome Mapping technology, software and
services are utilized by public health laboratories, health care institutions
and the life sciences community around the world for microbial strain typing,
comparative genomics, and sequence assembly and finishing. OpGen’s services
also include a CLIA-certified clinical services laboratory offering genetic
tests for the surveillance and identification of hospital acquired infections
(HAI) and human pathogens. For more information, please visit www.opgen.com.

Photos/Multimedia Gallery Available:



OpGen, Inc.
Michael Farmer, 240-813-1284
Director, Marketing
Pure Communications, Inc.
Dan Budwick (Media), 973-271-6085
Hitachi High-Tech Contacts:
Reiko Takeuchi (Media), +81-3-3504-7760
CSR & Corporate Communications Dept., CSR Div.
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