Eisai Announces Expansion of BELVIQ® (lorcaserin HCl) CIV Sales Specialists to Address Increased Payor Market

Eisai Announces Expansion of BELVIQ® (lorcaserin HCl) CIV Sales Specialists to
                        Address Increased Payor Market

BELVIQ® Sales Force to Double in Size by December 2013

PR Newswire

WOODCLIFF LAKE, N.J., Oct. 15, 2013

WOODCLIFF LAKE, N.J., Oct. 15, 2013 /PRNewswire/ --Eisai Inc. announced today
that, as part of its long-term marketing strategy, the company will expand its
sales force by adding more than 200 new contract sales representatives to its
Specialty Business Unit. The representatives will focus on educating
healthcare providers in the United States about BELVIQ^®, and will bring the
total sales force to approximately 400 by December, double the size from when
BELVIQ became available in June 2013. This expansion will allow Eisai to reach
approximately 65,000 physicians, including primary care providers,
endocrinologists, cardiovascular specialists, and gastrointestinal

The planned expansion of the sales force follows increased coverage of BELVIQ
by payors since the treatment first became available. According to BusinessOne
Technologies, a leader in managed markets-focused integrated data and
analytics business solutions, in addition to existing coverage, BELVIQ is now
also covered by several prominent health plans and pharmacy benefit managers
(PBMs) including, but not limited to, Express Scripts (including its legacy
Express Scripts and Medco operations), Tufts, Health Alliance Plan, Excellus
BCBS, Highmark BCBS, BCBS of Michigan, BCBS of North Carolina, and Healthnet
(California). While the exact coverage for BELVIQ varies by patient, this
improved access means more patients will receive coverage support from their
health plan or PBM. Patients can determine their precise benefit by calling
their healthcare plan provider or PBM.

"Eisai is deeply committed to launching innovative therapies with strong
support by the payor community. The expansion of our sales force demonstrates
the success we have gained in discussing the potential value of BELVIQ in
chronic weight management within the payor community, and the subsequent
agreements we have reached with many of our payor partners," said Lonnel
Coats, President and Chief Executive Officer, Eisai Inc. "We are in very
active and productive discussions with other major payors and fully expect the
reimbursement landscape will further improve as we head into 2014."

In addition to supporting physician education efforts, the sales force also
educates physicians about recently launched patient programs including the
BELIEVE EVERYDAY SUPPORT^SM program, which provides free, comprehensive
support and savings for BELVIQ patients, including a customizable online
portal designed to help some patients reach their weight loss goals and
sustain their efforts. Patients who obtain a BELVIQ prescription can enroll
for free online at BelieveSupport.com.

"We are thrilled that reimbursement for BELVIQ among payors is broadening,
helping to improve patient access to the treatment, which is at the forefront
of Eisai's human health care commitment to put patients and their families
first. We are pleased to announce the expansion of the sales force, ultimately
helping to communicate the safety and efficacy of BELVIQ as a chronic weight
management treatment option along with diet and exercise to a significantly
increased number of healthcare professionals," said Michael O'Brien, Vice
President, Specialty Marketing and Sales Business Unit for Eisai. "This
initiative is in alignment with our strategic vision and long-term goals for
BELVIQ of focusing on physician education, providing patient support and
increasing awareness, and addressing the need for expanded reimbursement
coverage among payors."

The new contract sales force representatives are currently located throughout
the United States.

About BELVIQ^®

BELVIQ is used along with a reduced-calorie diet and increased physical
activity for chronic weight management in adults who have a body mass index
(BMI) of 30 kg/m^2 or greater (obese), or BMI of 27 kg/m^2 or greater
(overweight) with at least one weight-related medical condition such as high
blood pressure, high cholesterol, or type 2 diabetes. It is not known if
BELVIQ is safe and effective when taken with other prescription,
over-the-counter, or herbal weight loss products, nor is it known if BELVIQ
changes the risk of heart problems or stroke, or death due to heart problems
or stroke.

BELVIQ is believed to decrease food consumption and promote satiety by
selectively activating serotonin 2C receptors in the brain. The exact
mechanism of action of BELVIQ is not known.

For more information about BELVIQ, click here for the full Product Information
or visit www.BELVIQ.com.

Important Safety Information

  oPregnancy: Do not take BELVIQ if you are pregnant or planning to become
    pregnant, as weight lossoffers no potential benefit during pregnancy and
    BELVIQ may harm your unborn baby.
  oSerotonin Syndrome or Neuroleptic Malignant Syndrome (NMS)-like reactions:
    Before using BELVIQ, tell your doctor about all the medicines you take,
    especially medicines that treat depression, migraines, mental problems, or
    the common cold. These medicines may cause serious or life-threatening
    side effects if taken with BELVIQ. Call your doctor right away if you
    experience agitation, hallucinations, confusion, or other changes in
    mental status; coordination problems; uncontrolled muscle spasms; muscle
    twitching; restlessness; racing or fast heartbeat; high or low blood
    pressure; sweating; fever; nausea; vomiting; diarrhea; or stiff muscles.
  oValvular heart disease: Some people taking medicines like BELVIQ have had
    heart valve problems. Call your doctor right away if you experience
    trouble breathing; swelling of the arms, legs, ankles, or feet; dizziness,
    fatigue, or weakness that will not go away; or fast or irregular
    heartbeat. Before taking BELVIQ, tell your doctor if you have or have had
    heart problems.
  oChanges in attention or memory: BELVIQ may slow your thinking. You should
    not drive a car or operate heavy equipment until you know how BELVIQ
    affects you.
  oMental problems: Taking too much BELVIQ may cause hallucinations, a
    feeling of being high or in a very good mood, or feelings of standing
    outside your body.
  oDepression or thoughts of suicide: Call your doctor right away if you
    notice any mental changes, especially sudden changes in your mood,
    behaviors, thoughts, or feelings, or if you have depression or thoughts of
  oLow blood sugar: Weight loss can cause low blood sugar in people taking
    medicines for type 2 diabetes, such as insulin or sulfonylureas. Blood
    sugar levels should be checked before and while taking BELVIQ. Changes to
    diabetes medication may be needed if low blood sugar develops.
  oPainful erections: If you have an erection lasting more than 4 hours while
    on BELVIQ, stop taking BELVIQ and call your doctor or go to the nearest
    emergency room right away.
  oSlow heartbeat: BELVIQ may cause your heart to beat slower.
  oDecreases in blood cell count: BELVIQ may cause your red and white blood
    cell counts to decrease.
  oIncrease in prolactin: BELVIQ may increase the amount of a hormone called
    prolactin. Tell your doctor if your breasts begin to make milk or a milky
    fluid, or if you are a male and your breasts increase in size.
  oMost common side effects in patients without diabetes: Headache,
    dizziness, fatigue, nausea, dry mouth, and constipation.
  oMost common side effects in patients with diabetes: Low blood sugar,
    headache, back pain, cough, and fatigue.
  oNursing: BELVIQ should not be taken while breastfeeding.
  oDrug interactions: Before taking BELVIQ, tell your doctor if you take
    medicines for depression, migraines, or other medical conditions, such as:
    triptans; medicines used to treat mood, anxiety, psychotic or thought
    disorders, including tricyclics, lithium, selective serotonin reuptake
    inhibitors, selective serotonin-norepinephrine reuptake inhibitors,
    monoamine oxidase inhibitors, or antipsychotics; cabergoline; linezolid
    (an antibiotic); tramadol; dextromethorphan (an over-the-counter (OTC)
    common cold/cough medicine); OTC supplements such as tryptophan or St.
    John's Wort; or erectile dysfunction medicines.

BELVIQ is a federally controlled substance (CIV) because it may be abused or
lead to drug dependence.

For more information about BELVIQ, click here for the full Product Information
or visit www.BELVIQ.com.

BELVIQ^® is a registered trademark of Arena Pharmaceuticals GmbH.

About Eisai Inc.

At Eisai Inc., human health care is our goal. We give our first thoughts to
patients and their families, and helping to increase the benefits health care
provides. As the U.S. pharmaceutical subsidiary of Tokyo-based Eisai Co.,
Ltd., we have a passionate commitment to patient care that is the driving
force behind our efforts to help address unmet medical needs. We are a fully
integrated pharmaceutical business with discovery, clinical, manufacturing and
marketing capabilities. Our key areas of commercial focus include oncology and
specialty care (Alzheimer's disease, epilepsy and metabolic disorders). To
learn more about Eisai Inc., please visit us at www.eisai.com/US.

Eisai Inc. has affiliates that are part of a global product creation
organization that includes R&D facilities in Massachusetts, New Jersey, North
Carolina and Pennsylvania, as well as a global demand chain organization that
includes manufacturing facilities in Maryland and North Carolina. Eisai's
global areas of R&D focus include neuroscience; oncology; metabolic disorders;
vascular, inflammatory and immunological reaction; and antibody-based

About BusinessOne Technologies, Inc.

BusinessOne Technologies, Inc., develops and deploys health care business
intelligence and data solutions, providing competitive, strategic analysis for
biotech and pharmaceutical manufacturers, PBMs, specialty pharmacy providers,
investment firms and other clients. Through its customizable, web-based
portal, Maestro™, end-users can access and analyze over 400 data elements
related to formulary and coverage policy control, benefit design,
reimbursement, demographics and utilization at the plan and physician level.
To learn more about BusinessOne Technologies, please visit

Media Inquiries Investor Inquiries
Marcia Diljak   Alex Scott
Eisai Inc.      Eisai Inc.
(201) 746-2236  (201) 746-2177

SOURCE Eisai Inc.

Website: http://www.eisai.com
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