RainDance Transforms Traditional Gene Expression Analysis by Adding One-Step Single Molecule RNA Detection Capabilities To

  RainDance Transforms Traditional Gene Expression Analysis by Adding One-Step
  Single Molecule RNA Detection Capabilities To RainDrop™ Digital PCR Platform

Company to unveil results from recent studies during upcoming CHI Digital PCR
                                  Conference

CHI Digital PCR Conference 2013

Business Wire

BILLERICA, Mass. -- October 3, 2013

RainDance Technologies, Inc todayannounced that it has added one-step single
molecule RNA detection capabilities to its RainDrop™ Digital PCR System. The
new workflow provides researchers with a simple method of counting individual
RNA target molecules. Available immediately to all current and future RainDrop
customers, the new capabilities are compatible with existing one-step master
mix solutions and a range of qPCR probes.

“Digital single molecule counting of RNA molecules is ultimately the most
precise, sensitive and accurate means of analysis. Other methods, such as RNA
sequencing, have many processing and amplification steps that introduce
significant bias,” said Andrew Watson, Chief Commercial Officer, RainDance
Technologies. “By adding single molecule RNA detection capabilities, the
RainDrop Digital PCR System now provides the industry’s most cost-effective
and deployable means of digital counting of RNA molecules.”

Transforming Traditional RNA Studies

The RainDrop System provides unique and enabling performance for RNA analysis.
During the CHI Digital PCR Conference, extensive experimental data will be
presented showing:

  *A wide dynamic range of six logs, enabling scientists to detect very low
    and very high abundance targets at the same time. This level of
    performance is crucial in many viral load detection applications, such as
    HIV and HPV studies where dose can vary greatly and emerging minor drug
    resistant strains need to be quantitatively analyzed.
  *Multiplex analysis of four different gene targets. Uniquely, the RainDrop
    System allows multiplexing of up to 12 targets, which is critical for
    broad deployment of gene expression based prognostic panels.
  *Detection of very subtle RNA level changes (+/- 10 percent). This will
    help transform applications such as neurobiology, where small changes in
    expression levels can have large effects.

Platform Versatility

The RainDrop Digital PCR System is also transforming molecular analysis by
enabling digital answers across a number of other applications. Today’s
announcement follows other recent published customer successes:

  *Publication in Journal of Clinical Chemistry demonstrated the use of the
    RainDrop Digital PCR system to detect multiple KRAS mutations directly
    from a liquid biopsy.
  *Scientists from the Massachusetts General Hospital demonstrated the use of
    a RainDrop Digital PCR System to detect glioma-associated mRNA mutations
    from cerebrospinal fluid.
  *Trovagene Inc. recently demonstrated that BRAF mutations present in
    trans-renal DNA from urine can be measured with unprecedented sensitivity
    by the RainDrop Digital PCR System.

For a complete list of RainDrop Digital PCR System publications, please visit
RainDanceTech.com/Publications.

CHI Digital PCR Conference

RainDance is demonstrating the RainDrop Digital PCR System in exhibition booth
#1 during next week’s Cambridge HealthTech (CHI) Digital PCR Conference:
Technologies and Tools for Precision Diagnostics in San Diego. Andrew Watson
will be presenting data supporting the one-step single molecule capabilities
on Tuesday, October 8^th at 2:45 pm PT. In addition, RainDrop System user, Dr.
Valerie Taly, group leader/CNRS researcher of Université Paris-Descartes, will
be presenting her data on cancer rare allele detection on Tuesday, October
8^th at 9:30 am PT. For more information about RainDance Technologies and its
portfolio of products, please visit:www.RainDanceTech.com.

About RainDance Technologies

RainDance Technologies is an emerging life sciences company developing
innovative products that enable more accurate, reliable, cost-effective and
early detection of disease and risk predisposition in order to improve human
healthcare. Today, RainDance is focused on better healthcare outcomes and
lowering costs for the research, detection and treatment of cancers and
inherited diseases. The company’s innovative RainStorm™ digital droplet
technology powers next-generation sequencing and genetic testing systems that
deliver dramatically superior performance, cost, interpretability, and ease of
use. RainDance systems are used routinely in major academic research
institutions, clinical genetics laboratories, and hospitals around the world.
Based in Billerica, Massachusetts, the company supports customers through its
international sales and service operations as well as a global network of
distributors and commercial service providers. For more information, please
visit www.RainDanceTech.com.

The RainDrop Digital PCR System is for Research Use Only; not for use in
diagnostic procedures.

RainDance Technologies, the RainDance Technologies logo, RainDrop, and Digital
Biology are trademarks of RainDance Technologies, Inc. All other brands may be
trademarks of their respective holders.

Contact:

Noble Communications
Andrew Noble, 415-722-2129
 
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