Euretina Presentation "Adoption of JETREA® in My Everyday Practice" Confirms
Need for a New Paradigm in Treatment of Symptomatic VMA/ VMT, Including Those
Cases Associated with MH
LEUVEN, Belgium, October 1, 2013
LEUVEN, Belgium, October 1, 2013 /PRNewswire/ --
Largest ever retrospective review of VMA/VMT patients confirms early treatment
initiation may stop disease progression and lead to better visual function
*Retrospective review of patients presenting with vitreomacular adhesion
(VMA), vitreomacular traction (VMT), macular hole (MH) with/ without VMA,
with or without visual symptoms (n=509)
*Review period: July 2009 - May 2013, with mean follow up of 2.03 years.
*VMA is a progressive disease: 16.4% of the eyes diagnosed with VMA
progressed to VMT within one year.
*Exact time and/or impact of progression are patient dependent.
*Spontaneous resolution of VMA occurred in 20% of patients with VMT
*Early treatment may be required to stop further disease progression and
improve visual function outcome.
ThromboGenics NV (Euronext Brussels: THR:BR), a biopharmaceutical company
focused on developing and commercializing innovative ophthalmic medicines,
announces that Prof. Dr. Peter Stalmans, Department of Ophthalmology,
University Hospitals Leuven, Belgium, delivered a presentation entitled
"Adoption of JETREA ^® in My Everyday Practice", at the recent EURETINA annual
meeting of European Society of Retina Specialists in Hamburg.
In his presentation, Prof. Stalmans provided details of the largest
retrospective, observational study to date, that looked at his "real world"
experience with patients with vitreomacular adhesion (VMA), vitreomacular
traction (VMT) and macular hole (MH).
Prof. Stalmans is working at a large, tertiary care ophthalmology center in
Leuven (Belgium). The Leuven center sees 50,000 ambulatory patients every year
and conducts around 2500 intravitreal injections and 7000 surgical procedures
per annum. The retrospective study is leveraging data collected from
electronic medical records gathered at the center between July 2009 and May
During EURETINA, Prof Stalmans also provided insights into his own successful
clinical experience with JETREA ^® when treating patients with early VMT and
Commenting on his presentation Prof. Dr. Peter Stalmans, Department of
Ophthalmology, University Hospitals Leuven says, " This is the largest
retrospective study conducted using high resolution OCT technology. The data
collected clearly shows that VMA/VMT is a progressive condition and that
spontaneous resolution of VMT is a low occurrence. Based on our findings I
believe that early treatment of these patients may be important if we are to
help them by resolving debilitating symptoms such as metamorphopsia, and
further sight threatening complications such as macular hole. My own
experience of treating patients experiencing metamorphopsia early with
JETREA ^® has been extremely good with the vast majority of patients
experiencing resolution of their traction. I look forward to treating many
more patients with this novel drug which I believe will play a key role in the
treatment of a wide range of patients with VMT. "
" This new VMA/VMT patient review is the largest ever available, " says Dr.
Patrik De Haes, CEO of ThromboGenics . " For the first time, we are able to
look at ' real life ' data provided from a tertiary center, " he
continues. " We are pleased to see how the results highlight the opportunity
for JETREA ^® as an early treatment option for those patients who would
normally only be observed. These new data and ' real life ' insights will
help us to further educate the community about the risk of disease progression
and the patient benefit of early treatment, " he concludes.
A video interview with Prof. Stalmans at Euretina is available at this link:
ThromboGenics is an integrated biopharmaceutical company focused on developing
and commercializing innovative ophthalmic and oncology medicines. The
Company's lead product, JETREA ^® (ocriplasmin), has been approved by the US
FDA for the treatment of symptomatic VMA and was launched in January 2013.
ThromboGenics signed a strategic partnership with Alcon (Novartis) for the
commercialization of JETREA ^® outside the United States. Under this
agreement, ThromboGenics could receive up to a total of €375 million in
up-front and milestone payments. It will receive significant royalties from
Alcon's net sales of JETREA ^® . ThromboGenics and Alcon intend to share the
costs equally of developing JETREA ^® for a number of new vitreoretinal
In Europe, JETREA ^® is approved for the treatment of vitreomacular traction
(VMT), including when associated with macular hole of diameter less than or
equal to 400 microns. Alcon has launched JETREA ^® in the UK, Germany,
Denmark, Norway, Finland and Sweden.
ThromboGenics is also further exploring anti-PIGF (Placental Growth Factor),
also referred to as TB-403.
ThromboGenics is headquartered in Leuven, Belgium, and has-offices in Iselin,
NJ (US) and Dublin, Ireland. The Company is listed on the NYSE Euronext
Brussels exchange under the symbol THR. More information is available at
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For further information please contact: ThromboGenics Wouter Piepers, Global
Head of Corporate Communications +32-16-75-13-10 / +32-478-33-56-32
Wouter.firstname.lastname@example.org Dr. Patrik De Haes, CEO +32-16-75-13-10
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