First Country in Europe Launches LATUDA® (lurasidone) - a New Atypical
Antipsychotic for Adults with Schizophrenia
Swiss launch marks the first step towards lurasidone becoming available across
ZURICH, September 10, 2013
ZURICH, September 10, 2013 /PRNewswire/ --
LATUDA ^® (lurasidone), a new once-daily treatment for schizophrenia, is now
available in Switzerland for the treatment of schizophrenia. ^ Research has
shown that the atypical antipsychotic, lurasidone, has a specific receptor
binding profile. ^
Symptom control and reducing relapse are primary goals of schizophrenia
therapy. ^ Lurasidone has been shown in clinical trials to offer both short
and long-term efficacy with a rapid onset of action that has demonstrated
effective symptom control as early as day four of treatment. ^ It has also
been shown to offer consistency of response across efficacy measures of
schizophrenia symptoms. ^
In addition to effective symptom control, it is important to minimize the
effect of treatment on long-term physical health as patients are likely to
need to remain on therapy for many years. Research has shown that there can be
associated problematic side effects such as weight gain and cholesterol
increases with schizophrenia treatments - both of which can lead to metabolic
and cardiovascular concerns in the longer term. ^ Recent research has shown
that lurasidone has a combination of efficacy and a favourable side effect
profile ^ which may help patients maintain their cardiometabolic health and
thereby improve their outcomes in the long term.
"As a committed psychiatrist, I am interested in new, effective agents for the
treatment of severely ill patients with mental disorders. This is particularly
true for patients who are not suitable for or not responded to currently
approved therapeutics. We need effective, well-tolerated and metabolically
neutral alternatives, which can also be used in young patients. Lurasidone has
an interesting profile of action," says Dr Philipp Eich, Stv Chefarzt,
Kantonale Psychiatrische Klinik Liestal, Switzerland.
Schizophrenia affects around 80,000 people in Switzerland and can affect both
men and women, with symptoms emerging in early adulthood. ^[ ^8 ^] As a
severe, chronic mental illness, the course of schizophrenia varies, but it is
generally characterized by psychotic episodes, with underlying negative and
cognitive symptoms and incomplete recovery between episodes. ^ Symptoms of
the condition can include so-called positive symptoms such as delusions, ^[ ^8
^] hallucinations, ^[ ^8 ^] reality distortion ^[ ^8 ^] and so-called negative
symptoms such as, blunted affect, emotional and social withdrawal/drive. ^[ ^8
" Today is an important landmark for Takeda in Europe as it marks our
first launch of a medicine from our emerging CNS portfolio -
lurasidone is an important driver in our initiatives to expand the
franchise for specialty care in Europe . We have a broad range of
medicines in development in significant areas of unmet clinical need and
we look forward to bringing innovative treatments to market that bring benefit
s to the wide st range of patients possible, " said Rene Gilvert, Vice
President Global Marketing and Therapeutic Area Lead CNS, Takeda
Takeda has also submitted a marketing authorization application (MAA) for
lurasidone in October 2012 to the European Medicines Agency (EMA). Takeda will
communicate the outcome of this application in the coming months.
Lurasidone is an atypical antipsychotic indicated for the treatment of
patients with schizophrenia. The effectiveness and efficacy of lurasidone for
longer-term use (for more than six weeks), has also been established in
controlled studies. ^ , ^
Lurasidone has been licensed in Switzerland for the treatment of
schizophrenia. Lurasidone was created and developed by Dainippon Sumitomo
Pharma Co. Ltd. and received FDA approval in October 2010 and has been
available in the US since 2011. It was also approved by Health Canada for
adults with schizophrenia in August 2011.
Please see important safety information including the black triangle
information and full prescribing information at Latuda Fachinformation,
Schizophrenia is a severe chronic mental condition which can affect both men
and women. Patients with schizophrenia have a life span that is decreased by
approximately 10-22.5 years compared with the general population. ^ ,
^ , ^ , ^
Antipsychotic pharmacotherapy is the cornerstone of treatment for patients
with schizophrenia, with agents generally classed as typical or atypical.
Atypical agents are broadly considered to have tolerability benefits over
typical agents. ^ Switching antipsychotic medication is common in the
treatment of patients with schizophrenia either due to residual or emergent
symptoms, adverse events or tolerability issues. ^ ^, ^
Direct and indirect costs associated with caring for patients with
schizophrenia are considerable and can include utilization of other health
services, pharmacotherapy, community care, supportive therapy, informal care
and private expenditures, and patient and caregiver lost productivity. ^
^, ^ Hospitalization associated with patient relapse can significantly
increase costs associated with disease management in schizophrenia. ^
About Takeda Pharmaceuticals International GmbH
Takeda Pharmaceuticals International GmbH, headquartered in Zurich, is a
wholly owned subsidiary of Takeda Pharmaceutical Company Limited. As the
largest pharmaceutical company in Japan and a leader in the global industry,
Takeda's mission is to strive toward better health for patients worldwide
through leading innovation in medicine. It has a commercial presence covering
more than 70 countries, with particular strength in Asia, North America,
Europe and fast-growing emerging markets including Latin America, Russia-CIS
and China. Takeda is ranked 12th by global Rx sales, 14th in the BRIC
countries and 18th in Europe. Takeda's commercial presence mainly covers the
therapeutic areas of metabolic diseases, gastroenterology, oncology,
cardiovascular health, CNS diseases, inflammatory and immune disorders,
respiratory diseases and pain management.
Additional information about Takeda is available through its corporate
website, http://www.takeda.com .
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4. Swiss SmPC - June 2013
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6. Daumit GL et al. Antipsychotic effects on estimated 10-year coronary heart
disease risk in the CATIE schizophrenia study. Schizophr Res 2008
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prevention in schizophrenia: a 12-month, double-blind, noninferiority study.
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conc~ptualization. Schizophr Res 2009;110:1-23.
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10. Meltzer H et al. Lurasidone in the Treatment of Schizophrenia: A
Randomized, Double-Blind, Placebo- and Olanzapine- Controlled Study. Am J
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two cohorts, 1875-1924 and 1994-2010. BMJ Open 2012;2:e001810.
12. Chang C-K et al. Life Expectancy at Birth for People with Serious Mental
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16. Faries DE et al. Clinical and economic ramifications of switching
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Policy Econ 2007;10(1):23-41.
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Contact: Media Enquiry Contacts: Kate Burd, Takeda Pharmaceuticals
International GmbH, +44-7974-151510, Kate.firstname.lastname@example.org ; Arran Attridge,
Red Door Communications, +44-7812-398-525, email@example.com
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